FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955663742> ?p ?o ?g. }

• W2955663742 endingPage "316" @default.
• W2955663742 startingPage "307" @default.
• W2955663742 abstract "Aim and Objective: To study the structural difference, optimization, molecular docking and development of new benzoyl amino phenoxy phenol derivatives as anti-prostate cancer agents. Material and Methods: Strategies towards the identification of novel benzoyl amino phenoxy phenol (BAPP), molecular docking was performed with the designed Androgen Receptor (AR) blockers. Pharmacophore-based studies revealed that the nitro- or cyano-substituted anilide groups have influenced the activity profiles of non-steroidal AR antagonists, followed by the molecular docking studies with five AR receptors. Molecular docking studies were carried out using Maestro from Schrödinger. Absorption, Distribution, Metabolism, and Excretion (ADME) properties of the BAPP derivatives were evaluated for the predictive bioavailability/drug-likeness. These studies supported vital information for designing new anti-prostate cancer agents. Results and Discussion: There are 125 compounds were screened and best fit compounds (12 entries) were well-synthesized in good to excellent yields and anticancer activities were evaluated. The compounds, 6i showed the highest activities of this series (14.65 ± 1.35 µM). Conclusion: The present approach is simple and efficient for the synthesis of BAPP derivatives and the observed IC50 values of BAPPs were in good agreement with the glide scores obtained from the molecular docking. We, further, intend to carry out in vitro and in vivo AR binding studies for the active compounds." @default.
• W2955663742 created "2019-07-12" @default.
• W2955663742 creator A5053817882 @default.
• W2955663742 creator A5063123167 @default.
• W2955663742 creator A5065619859 @default.
• W2955663742 creator A5079210976 @default.
• W2955663742 creator A5083783940 @default.
• W2955663742 date "2019-08-08" @default.
• W2955663742 modified "2023-09-23" @default.
• W2955663742 title "In Silico Molecular Docking, Synthesis of 4-(4-benzoylaminophenoxy) Phenol Derivatives as Androgen Receptor Antagonists" @default.
• W2955663742 cites W1963614127 @default.
• W2955663742 cites W1969309753 @default.
• W2955663742 cites W1981989535 @default.
• W2955663742 cites W1985588649 @default.
• W2955663742 cites W2001379731 @default.
• W2955663742 cites W2009423060 @default.
• W2955663742 cites W2014655360 @default.
• W2955663742 cites W2045629811 @default.
• W2955663742 cites W2082817121 @default.
• W2955663742 cites W2102377211 @default.
• W2955663742 cites W2296347497 @default.
• W2955663742 cites W2340808473 @default.
• W2955663742 cites W2416475108 @default.
• W2955663742 cites W2528110283 @default.
• W2955663742 cites W2580552667 @default.
• W2955663742 cites W2741909312 @default.
• W2955663742 cites W2801622042 @default.
• W2955663742 cites W2889319937 @default.
• W2955663742 cites W2906805357 @default.
• W2955663742 cites W2914749530 @default.
• W2955663742 doi "https://doi.org/10.2174/1386207322666190701124752" @default.
• W2955663742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31267866" @default.
• W2955663742 hasPublicationYear "2019" @default.
• W2955663742 type Work @default.
• W2955663742 sameAs 2955663742 @default.
• W2955663742 citedByCount "7" @default.
• W2955663742 countsByYear W29556637422022 @default.
• W2955663742 countsByYear W29556637422023 @default.
• W2955663742 crossrefType "journal-article" @default.
• W2955663742 hasAuthorship W2955663742A5053817882 @default.
• W2955663742 hasAuthorship W2955663742A5063123167 @default.
• W2955663742 hasAuthorship W2955663742A5065619859 @default.
• W2955663742 hasAuthorship W2955663742A5079210976 @default.
• W2955663742 hasAuthorship W2955663742A5083783940 @default.
• W2955663742 hasConcept C121608353 @default.
• W2955663742 hasConcept C126322002 @default.
• W2955663742 hasConcept C150903083 @default.
• W2955663742 hasConcept C159110408 @default.
• W2955663742 hasConcept C178790620 @default.
• W2955663742 hasConcept C181389837 @default.
• W2955663742 hasConcept C185592680 @default.
• W2955663742 hasConcept C202751555 @default.
• W2955663742 hasConcept C207001950 @default.
• W2955663742 hasConcept C21951064 @default.
• W2955663742 hasConcept C2777702071 @default.
• W2955663742 hasConcept C2780192828 @default.
• W2955663742 hasConcept C41685203 @default.
• W2955663742 hasConcept C55493867 @default.
• W2955663742 hasConcept C56173144 @default.
• W2955663742 hasConcept C61367390 @default.
• W2955663742 hasConcept C69366308 @default.
• W2955663742 hasConcept C70721500 @default.
• W2955663742 hasConcept C71240020 @default.
• W2955663742 hasConcept C71924100 @default.
• W2955663742 hasConcept C86803240 @default.
• W2955663742 hasConcept C98274493 @default.
• W2955663742 hasConceptScore W2955663742C121608353 @default.
• W2955663742 hasConceptScore W2955663742C126322002 @default.
• W2955663742 hasConceptScore W2955663742C150903083 @default.
• W2955663742 hasConceptScore W2955663742C159110408 @default.
• W2955663742 hasConceptScore W2955663742C178790620 @default.
• W2955663742 hasConceptScore W2955663742C181389837 @default.
• W2955663742 hasConceptScore W2955663742C185592680 @default.
• W2955663742 hasConceptScore W2955663742C202751555 @default.
• W2955663742 hasConceptScore W2955663742C207001950 @default.
• W2955663742 hasConceptScore W2955663742C21951064 @default.
• W2955663742 hasConceptScore W2955663742C2777702071 @default.
• W2955663742 hasConceptScore W2955663742C2780192828 @default.
• W2955663742 hasConceptScore W2955663742C41685203 @default.
• W2955663742 hasConceptScore W2955663742C55493867 @default.
• W2955663742 hasConceptScore W2955663742C56173144 @default.
• W2955663742 hasConceptScore W2955663742C61367390 @default.
• W2955663742 hasConceptScore W2955663742C69366308 @default.
• W2955663742 hasConceptScore W2955663742C70721500 @default.
• W2955663742 hasConceptScore W2955663742C71240020 @default.
• W2955663742 hasConceptScore W2955663742C71924100 @default.
• W2955663742 hasConceptScore W2955663742C86803240 @default.
• W2955663742 hasConceptScore W2955663742C98274493 @default.
• W2955663742 hasFunder F4320320717 @default.
• W2955663742 hasIssue "5" @default.
• W2955663742 hasLocation W29556637421 @default.
• W2955663742 hasLocation W29556637422 @default.
• W2955663742 hasOpenAccess W2955663742 @default.
• W2955663742 hasPrimaryLocation W29556637421 @default.
• W2955663742 hasRelatedWork W1548945415 @default.
• W2955663742 hasRelatedWork W2016888480 @default.
• W2955663742 hasRelatedWork W2308678183 @default.
• W2955663742 hasRelatedWork W2725755800 @default.

• next