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- W2955665061 abstract "Riboswitches are conformationally dynamic RNAs that regulate gene expression by binding specific small molecules. ZTP riboswitches bind the purine-biosynthetic intermediate 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate (ZMP) and its triphosphorylated form (ZTP). Ligand binding to this riboswitch ultimately upregulates genes involved in folate and purine metabolism. Using an X-ray free-electron laser (XFEL), the room-temperature structure of the Fusobacterium ulcerans ZTP riboswitch bound to ZMP has now been determined at 4.1 A resolution. This model, which was refined against a data set from ∼750 diffraction images (each from a single crystal), was found to be consistent with that previously obtained from data collected at 100 K using conventional synchrotron X-radiation. These experiments demonstrate the feasibility of time-resolved XFEL experiments to understand how the ZTP riboswitch accommodates cognate ligand binding." @default.
- W2955665061 created "2019-07-12" @default.
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- W2955665061 date "2019-07-01" @default.
- W2955665061 modified "2023-09-27" @default.
- W2955665061 title "Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser." @default.
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- W2955665061 doi "https://doi.org/10.2210/pdb6od9/pdb" @default.
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