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- W2955667083 abstract "Introduction: It is important to predict prognosis in patients with advanced gastric cancer receiving chemotherapy. Several studies have reported that Glasgow prognostic score (GPS), which was based on serum albumin (Alb) and C-reactive protein (CRP), was associated with poor prognosis in many cancers. However, it is unclear whether GPS has prognostic value when patients receive irinotecan, which is a key drug of advanced gastric cancer. Methods: We conducted a retrospective multicenter study and investigated the association between efficacy and GPS in patients who received irinotecan monotherapy between January 2010 and December 2017. All patients had to receive fluoropyrimidine and platinum as prior therapy. GPS was identified such that GPS 0 was CRP ≤1.0 mg/dL and Alb ≥3.5 g/dL, GPS 1 was CRP >1.0 mg/dL or Alb 1.0 mg/dL and Alb < 3.5 g/dL, and GPS 2 was CRP > 1.0 mg/dL and Alb < 3.5 g/dL. Results: There were 174 patients at 8 centers included in this study. The number of patients with GPS 0/1/2 was 76/56/42, respectively. In GPS 0/1/2 patients, performance status (0-1/2≤), treatment line 2nd/3rd or later, and HER2 status were significantly different among them (P < .01). As for safety, there was no significant difference amongst GPS 0/1/2 patients. In GPS 0/1/2 patients, median PFS were 3.7/2.8/2.0 months (P < .01), median OS were 11.9/7.2/6.7 months (P < .01), respectively. In multivariate analysis, GPS was associated with shorter PFS (GPS 0 vs 1/0vs 2; HR 1.180/2.378; 95% CI, 0.793-1.758/1.405-4.024; P = .414/.001), and shorter OS (GPS 0 vs 1/0vs 2; HR 1.520/2.529; 95% CI, 1.002-2.305/1.518-4.213; P = .049/< .001). Conclusion: According to this analysis, GPS might be a predictive and prognostic factor for treatment with irinotecan monotherapy in patients with AGC." @default.
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- W2955667083 date "2019-07-01" @default.
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- W2955667083 title "A retrospective multicenter study evaluating the efficacy and safety of irinotecan in patients with advanced gastric cancer: analysis of Glasgow prognostic score (GPS)" @default.
- W2955667083 doi "https://doi.org/10.1093/annonc/mdz155.151" @default.
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