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• W2955691957 abstract "ABSTRACT Nedd4-2 is an E3 ubiquitin ligase, missense mutation of which is related to familial epilepsy, indicating its critical role in regulating neuronal network activity. However, Nedd4-2 substrates involved in neuronal network function have yet to be identified. Using mouse lines lacking Nedd4-1 and Nedd4-2, we identified astrocytic channel proteins inwardly rectifying K + channel 4.1 (Kir4.1) and Connexin43 as Nedd4-2 substrates. We found that the expression of Kir4.1 and Connexin43 is increased upon conditional deletion of Nedd4-2 in astrocytes, leading to an elevation of astrocytic membrane ion permeability and gap junction activity, with a consequent reduction of γ-oscillatory neuronal network activity. Interestingly, our biochemical data demonstrate that missense mutations found in familial epileptic patients produce gain-of-function of Nedd4-2 gene product. Our data reveal a process of coordinated astrocytic ion channel proteostasis that controls astrocyte function and astrocyte-dependent neuronal network activity, and elucidate a potential mechanism by which aberrant Nedd4-2 function leads to epilepsy. CONDENSED TITLE Ubiquitination of Astrocytic Channels by Nedd4-2 SUMMARY Ubiquitination is a key regulatory machinery for protein expression. Our present work provides evidence that astrocytic ion channel proteostasis coordinated by an E3 ubiquitin ligase Nedd4-2 is of particular importance for the maintenance of neuronal network activity." @default.
• W2955691957 created "2019-07-12" @default.
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• W2955691957 date "2019-07-04" @default.
• W2955691957 modified "2023-10-17" @default.
• W2955691957 title "Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2" @default.
• W2955691957 cites W1582195464 @default.
• W2955691957 cites W1749057191 @default.
• W2955691957 cites W1954747488 @default.
• W2955691957 cites W1967479102 @default.
• W2955691957 cites W1968226795 @default.
• W2955691957 cites W1968314092 @default.
• W2955691957 cites W1972252092 @default.
• W2955691957 cites W1977832158 @default.
• W2955691957 cites W1977873342 @default.
• W2955691957 cites W1979910363 @default.
• W2955691957 cites W1986108347 @default.
• W2955691957 cites W1991669847 @default.
• W2955691957 cites W1992444259 @default.
• W2955691957 cites W1998718798 @default.
• W2955691957 cites W2000432680 @default.
• W2955691957 cites W2003647187 @default.
• W2955691957 cites W2003721954 @default.
• W2955691957 cites W2008183439 @default.
• W2955691957 cites W2012254833 @default.
• W2955691957 cites W2013752437 @default.
• W2955691957 cites W2019245227 @default.
• W2955691957 cites W2026153752 @default.
• W2955691957 cites W2028380145 @default.
• W2955691957 cites W2034675173 @default.
• W2955691957 cites W2040856928 @default.
• W2955691957 cites W2042170986 @default.
• W2955691957 cites W2048988573 @default.
• W2955691957 cites W2050706464 @default.
• W2955691957 cites W2059487035 @default.
• W2955691957 cites W2064583316 @default.
• W2955691957 cites W2064786217 @default.
• W2955691957 cites W2078320539 @default.
• W2955691957 cites W2079955127 @default.
• W2955691957 cites W2080752012 @default.
• W2955691957 cites W2080794145 @default.
• W2955691957 cites W2081042958 @default.
• W2955691957 cites W2084632339 @default.
• W2955691957 cites W2092357835 @default.
• W2955691957 cites W2101644199 @default.
• W2955691957 cites W2104135721 @default.
• W2955691957 cites W2107277218 @default.
• W2955691957 cites W2109256677 @default.
• W2955691957 cites W2112032807 @default.
• W2955691957 cites W2112800304 @default.
• W2955691957 cites W2120016245 @default.
• W2955691957 cites W2129110633 @default.
• W2955691957 cites W2130784302 @default.
• W2955691957 cites W2136124094 @default.
• W2955691957 cites W2149561999 @default.
• W2955691957 cites W2150024906 @default.
• W2955691957 cites W2157527374 @default.
• W2955691957 cites W2158211937 @default.
• W2955691957 cites W2162423225 @default.
• W2955691957 cites W2163755116 @default.
• W2955691957 cites W2164963523 @default.
• W2955691957 cites W2166987747 @default.
• W2955691957 cites W2167661117 @default.
• W2955691957 cites W2277434785 @default.
• W2955691957 cites W2343448033 @default.
• W2955691957 cites W2412764356 @default.
• W2955691957 cites W2463195069 @default.
• W2955691957 cites W2561266809 @default.
• W2955691957 cites W2588691401 @default.
• W2955691957 cites W2590592231 @default.
• W2955691957 cites W2613476512 @default.
• W2955691957 cites W2752703006 @default.
• W2955691957 cites W2787343838 @default.
• W2955691957 cites W2794585550 @default.
• W2955691957 cites W2795075974 @default.
• W2955691957 cites W2808544539 @default.
• W2955691957 cites W2891508509 @default.
• W2955691957 doi "https://doi.org/10.1101/683441" @default.
• W2955691957 hasPublicationYear "2019" @default.
• W2955691957 type Work @default.

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