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- W2955698903 abstract "Objective: TP53 mutations are common in epithelial ovarian cancer. Hyperradiation sensitivity (HRS) is enhanced in cells with mutant TP53, where effective cell killing occurs even at very low doses, ~0.1 Gy, of radiation. HRS in the form of low-dose fractionated radiation therapy (LDFRT) has been associated with upregulation of several pro-apoptotic proteins in tumors, thus potentiating the efficacy of chemotherapy. We hypothesized that combining low-dose fractionated whole abdominal radiation therapy (LDWART) as a chemosensitizer with weekly paclitaxel (WP) may be feasible and safe for patients with platinum-resistant ovarian cancer and evaluated this novel therapeutic combination in a phase I study." @default.
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- W2955698903 date "2019-06-01" @default.
- W2955698903 modified "2023-09-30" @default.
- W2955698903 title "Use of low-dose whole abdominal radiation therapy (LDWART) as a chemosensitizer in combination with weekly paclitaxel for platinum-resistant ovarian cancer: Safety analysis" @default.
- W2955698903 doi "https://doi.org/10.1016/j.ygyno.2019.04.404" @default.
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