FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955709019> ?p ?o ?g. }

• W2955709019 endingPage "1867" @default.
• W2955709019 startingPage "1849" @default.
• W2955709019 abstract "We aimed to assess the roles of small nucleolar RNA host gene 6 (SNHG6) in hepatocellular carcinoma (HCC) progression, and establish the lncRNA-miRNA-mRNA regulation mechanism for HCC therapy. SNHG6 is one of the host genes in small nucleolar RNAs (snoRNAs), which make a difference in the development of human cancers. SERPINH1 is a gene encoding a member of the serpin superfamily of serine proteinase inhibitors with miRNA predicted by TargetScan and DIANA Tools. SNHG6, serpin family H member 1 (SERPINH1) and miR-139-5p expression levels in HCC tissues and cells were determined by quantitative real-time PCR (qRT-PCR). Migration and invasion of HCC cells were measured by transwell assay. Cell cycle analysis was determined by using flow cytometry. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and colony formation assay were performed for cell viability analysis. The expression of SERPINH1 was detected by qRT-PCR and western blot. Dual-luciferase reporter gene assay was conducted to identify the targeted relationship between miR-139-5p and SNHG6, as well as SERPINH1 and miR-139-5p. The positive regulation between SNHG6 and SERPINH1 was demonstrated in this study. In contrast, miR-139-5p was significantly down-regulated in HCC cells, the inhibition of miR-139-5p promotes the proliferation of HCC cells, and accelerated the cell cycle of HCC cells. Our study demonstrated the co-expression of SNHG6 and SERPINH1 in HCC cells for the first time, which revealed that SNHG6 could serve as a novel oncogene for the HCC therapy by its regulation." @default.
• W2955709019 created "2019-07-12" @default.
• W2955709019 creator A5032840812 @default.
• W2955709019 creator A5048752861 @default.
• W2955709019 creator A5052259964 @default.
• W2955709019 creator A5053555867 @default.
• W2955709019 creator A5067251010 @default.
• W2955709019 date "2019-07-01" @default.
• W2955709019 modified "2023-10-14" @default.
• W2955709019 title "Up-regulation of <i>SNHG6</i> activates <i>SERPINH1</i> expression by competitive binding to miR-139-5p to promote hepatocellular carcinoma progression" @default.
• W2955709019 cites W1439006730 @default.
• W2955709019 cites W1977060570 @default.
• W2955709019 cites W1979285004 @default.
• W2955709019 cites W1981834102 @default.
• W2955709019 cites W1989565979 @default.
• W2955709019 cites W2010105352 @default.
• W2955709019 cites W2029861523 @default.
• W2955709019 cites W2035395393 @default.
• W2955709019 cites W2050278645 @default.
• W2955709019 cites W2055509265 @default.
• W2955709019 cites W2110957978 @default.
• W2955709019 cites W2113047680 @default.
• W2955709019 cites W2117951804 @default.
• W2955709019 cites W2122029850 @default.
• W2955709019 cites W2136222002 @default.
• W2955709019 cites W2136362813 @default.
• W2955709019 cites W2162547088 @default.
• W2955709019 cites W2269175947 @default.
• W2955709019 cites W2318208171 @default.
• W2955709019 cites W2418269535 @default.
• W2955709019 cites W2486147505 @default.
• W2955709019 cites W2512011967 @default.
• W2955709019 cites W2514971678 @default.
• W2955709019 cites W2529051581 @default.
• W2955709019 cites W2529101375 @default.
• W2955709019 cites W2551012893 @default.
• W2955709019 cites W2598984514 @default.
• W2955709019 cites W2615277108 @default.
• W2955709019 cites W2762002459 @default.
• W2955709019 cites W2783583678 @default.
• W2955709019 cites W2888354601 @default.
• W2955709019 cites W2912546681 @default.
• W2955709019 cites W4211183069 @default.
• W2955709019 doi "https://doi.org/10.1080/15384101.2019.1629772" @default.
• W2955709019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6681790" @default.
• W2955709019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31258024" @default.
• W2955709019 hasPublicationYear "2019" @default.
• W2955709019 type Work @default.
• W2955709019 sameAs 2955709019 @default.
• W2955709019 citedByCount "24" @default.
• W2955709019 countsByYear W29557090192020 @default.
• W2955709019 countsByYear W29557090192021 @default.
• W2955709019 countsByYear W29557090192022 @default.
• W2955709019 countsByYear W29557090192023 @default.
• W2955709019 crossrefType "journal-article" @default.
• W2955709019 hasAuthorship W2955709019A5032840812 @default.
• W2955709019 hasAuthorship W2955709019A5048752861 @default.
• W2955709019 hasAuthorship W2955709019A5052259964 @default.
• W2955709019 hasAuthorship W2955709019A5053555867 @default.
• W2955709019 hasAuthorship W2955709019A5067251010 @default.
• W2955709019 hasBestOaLocation W29557090191 @default.
• W2955709019 hasConcept C104317684 @default.
• W2955709019 hasConcept C145059251 @default.
• W2955709019 hasConcept C1491633281 @default.
• W2955709019 hasConcept C150194340 @default.
• W2955709019 hasConcept C153911025 @default.
• W2955709019 hasConcept C161733203 @default.
• W2955709019 hasConcept C179255354 @default.
• W2955709019 hasConcept C194993378 @default.
• W2955709019 hasConcept C2781018059 @default.
• W2955709019 hasConcept C29537977 @default.
• W2955709019 hasConcept C502942594 @default.
• W2955709019 hasConcept C53227056 @default.
• W2955709019 hasConcept C54355233 @default.
• W2955709019 hasConcept C553184892 @default.
• W2955709019 hasConcept C62112901 @default.
• W2955709019 hasConcept C86803240 @default.
• W2955709019 hasConceptScore W2955709019C104317684 @default.
• W2955709019 hasConceptScore W2955709019C145059251 @default.
• W2955709019 hasConceptScore W2955709019C1491633281 @default.
• W2955709019 hasConceptScore W2955709019C150194340 @default.
• W2955709019 hasConceptScore W2955709019C153911025 @default.
• W2955709019 hasConceptScore W2955709019C161733203 @default.
• W2955709019 hasConceptScore W2955709019C179255354 @default.
• W2955709019 hasConceptScore W2955709019C194993378 @default.
• W2955709019 hasConceptScore W2955709019C2781018059 @default.
• W2955709019 hasConceptScore W2955709019C29537977 @default.
• W2955709019 hasConceptScore W2955709019C502942594 @default.
• W2955709019 hasConceptScore W2955709019C53227056 @default.
• W2955709019 hasConceptScore W2955709019C54355233 @default.
• W2955709019 hasConceptScore W2955709019C553184892 @default.
• W2955709019 hasConceptScore W2955709019C62112901 @default.
• W2955709019 hasConceptScore W2955709019C86803240 @default.
• W2955709019 hasFunder F4320321001 @default.
• W2955709019 hasIssue "16" @default.
• W2955709019 hasLocation W29557090191 @default.
• W2955709019 hasLocation W29557090192 @default.
• W2955709019 hasLocation W29557090193 @default.

• next