FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955749966> ?p ?o ?g. }

• W2955749966 endingPage "829" @default.
• W2955749966 startingPage "817" @default.
• W2955749966 abstract "The morphology and between-eye symmetry of the visual field loss associated with the antiepileptic drug vigabatrin (VAVFL) has received little attention. Our objective was to model the appearance and ensuing staging of VAVFL derived with the European Medicines Agency-approved perimetric protocol. This was a retrospective, cross-sectional, observational study that identified 123 adults who had received vigabatrin for refractory seizures and who had no evidence of co-existing retino-geniculo-cortical visual pathway abnormality. A further 38 adults with refractory seizures and identical inclusion criteria but no exposure to vigabatrin acted as controls. For each group, the median outcome at each stimulus location in each eye (of absolute loss, relative loss or Pattern Deviation probability level, as appropriate) was derived for each successive ten pairs of fields, ranked for severity. Between-eye symmetry was quantified by an index that accounted for severity of loss and that was referenced to the likelihood of the occurrence of symmetry due to chance. The modelled VAVFL was bilateral and highly symmetrical and was described by six stages that were all independent of the extent of vigabatrin exposure. The loss originated in the extreme temporal periphery and encroached centripetally along all meridians towards fixation. The initial appearance within the central field (Stage 2) occurred inferior-nasally. Subsequent stages exhibited increasing loss, which was greater nasally than temporally. Stage 6 described concentric loss extending to approximately 15° eccentricity from fixation. The model exhibited a consistent pattern of VAVFL. The staging of the loss could assist the risk:benefit analysis of vigabatrin for the treatment of epilepsy." @default.
• W2955749966 created "2019-07-12" @default.
• W2955749966 creator A5011085036 @default.
• W2955749966 creator A5019751830 @default.
• W2955749966 creator A5024606893 @default.
• W2955749966 date "2019-06-27" @default.
• W2955749966 modified "2023-10-10" @default.
• W2955749966 title "Objective Derivation of the Morphology and Staging of Visual Field Loss Associated with Long-Term Vigabatrin Therapy" @default.
• W2955749966 cites W1542887848 @default.
• W2955749966 cites W154809504 @default.
• W2955749966 cites W1607402462 @default.
• W2955749966 cites W1948601338 @default.
• W2955749966 cites W1988302543 @default.
• W2955749966 cites W2007156436 @default.
• W2955749966 cites W2014407178 @default.
• W2955749966 cites W2021547803 @default.
• W2955749966 cites W2038749218 @default.
• W2955749966 cites W2049214932 @default.
• W2955749966 cites W2050219242 @default.
• W2955749966 cites W2056539787 @default.
• W2955749966 cites W2058677302 @default.
• W2955749966 cites W2059167774 @default.
• W2955749966 cites W2059415178 @default.
• W2955749966 cites W2069995172 @default.
• W2955749966 cites W2080221650 @default.
• W2955749966 cites W2085048192 @default.
• W2955749966 cites W2085050047 @default.
• W2955749966 cites W2088030006 @default.
• W2955749966 cites W2088132894 @default.
• W2955749966 cites W2094803132 @default.
• W2955749966 cites W2095185628 @default.
• W2955749966 cites W2105517894 @default.
• W2955749966 cites W2106424911 @default.
• W2955749966 cites W2115647035 @default.
• W2955749966 cites W2116602570 @default.
• W2955749966 cites W2133572298 @default.
• W2955749966 cites W2138475110 @default.
• W2955749966 cites W2149094349 @default.
• W2955749966 cites W2159399505 @default.
• W2955749966 cites W2162594619 @default.
• W2955749966 cites W2274013449 @default.
• W2955749966 cites W2294804959 @default.
• W2955749966 cites W2324858884 @default.
• W2955749966 cites W2512476827 @default.
• W2955749966 cites W2518091438 @default.
• W2955749966 cites W2775900815 @default.
• W2955749966 cites W2909299171 @default.
• W2955749966 cites W4213009331 @default.
• W2955749966 doi "https://doi.org/10.1007/s40263-019-00634-2" @default.
• W2955749966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31250314" @default.
• W2955749966 hasPublicationYear "2019" @default.
• W2955749966 type Work @default.
• W2955749966 sameAs 2955749966 @default.
• W2955749966 citedByCount "5" @default.
• W2955749966 countsByYear W29557499662019 @default.
• W2955749966 countsByYear W29557499662020 @default.
• W2955749966 countsByYear W29557499662021 @default.
• W2955749966 countsByYear W29557499662023 @default.
• W2955749966 crossrefType "journal-article" @default.
• W2955749966 hasAuthorship W2955749966A5011085036 @default.
• W2955749966 hasAuthorship W2955749966A5019751830 @default.
• W2955749966 hasAuthorship W2955749966A5024606893 @default.
• W2955749966 hasBestOaLocation W29557499662 @default.
• W2955749966 hasConcept C118487528 @default.
• W2955749966 hasConcept C118552586 @default.
• W2955749966 hasConcept C141071460 @default.
• W2955749966 hasConcept C2775858608 @default.
• W2955749966 hasConcept C2776058522 @default.
• W2955749966 hasConcept C2778186239 @default.
• W2955749966 hasConcept C2780837902 @default.
• W2955749966 hasConcept C2908575184 @default.
• W2955749966 hasConcept C50965678 @default.
• W2955749966 hasConcept C71924100 @default.
• W2955749966 hasConceptScore W2955749966C118487528 @default.
• W2955749966 hasConceptScore W2955749966C118552586 @default.
• W2955749966 hasConceptScore W2955749966C141071460 @default.
• W2955749966 hasConceptScore W2955749966C2775858608 @default.
• W2955749966 hasConceptScore W2955749966C2776058522 @default.
• W2955749966 hasConceptScore W2955749966C2778186239 @default.
• W2955749966 hasConceptScore W2955749966C2780837902 @default.
• W2955749966 hasConceptScore W2955749966C2908575184 @default.
• W2955749966 hasConceptScore W2955749966C50965678 @default.
• W2955749966 hasConceptScore W2955749966C71924100 @default.
• W2955749966 hasIssue "8" @default.
• W2955749966 hasLocation W29557499661 @default.
• W2955749966 hasLocation W29557499662 @default.
• W2955749966 hasLocation W29557499663 @default.
• W2955749966 hasOpenAccess W2955749966 @default.
• W2955749966 hasPrimaryLocation W29557499661 @default.
• W2955749966 hasRelatedWork W1033751384 @default.
• W2955749966 hasRelatedWork W1986159818 @default.
• W2955749966 hasRelatedWork W1993165922 @default.
• W2955749966 hasRelatedWork W2042103292 @default.
• W2955749966 hasRelatedWork W2075211857 @default.
• W2955749966 hasRelatedWork W2089822285 @default.
• W2955749966 hasRelatedWork W2163662781 @default.
• W2955749966 hasRelatedWork W2404581573 @default.
• W2955749966 hasRelatedWork W2460686807 @default.

• next