Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955754664> ?p ?o ?g. }
- W2955754664 endingPage "7696" @default.
- W2955754664 startingPage "7684" @default.
- W2955754664 abstract "Oxidative stress is the basic reason for aging and age-related diseases. In this study, we investigated the protective effect of 2 strains of lactic acid bacteria (LAB), Lactobacillus rhamnosus GG and L. plantarum J26, against oxidative stress in Caco-2 cells, and gave an overview of the mechanisms of lactic acid bacteria antioxidant activity using digital gene expression profiling. The 2 LAB strains provided significant protection against hydrogen peroxide (H2O2)–induced reduction in superoxide dismutase activity and increase in glutathione peroxidase activity in Caco-2 cells. However, inactive bacteria had little effect on alleviating oxidation stress in Caco-2 cells. Eight genes related to oxidative stress—FOSB, TNF, PPP1R15A, NUAK2, ATF3, TNFAIP3, EGR2, and FBN2—were significantly upregulated in H2O2-induced Caco-2 cells compared with untreated Caco-2 cells. After incubation of the H2O2-induced Caco-2 cells with L. rhamnosus GG and L. plantarum J26, 5 genes (TNF, EGR2, NUAK2, FBN2, and TNFAIP3) and 2 genes (NUAK2 and FBN2) were downregulated, respectively. In addition, the Kyoto Encyclopedia of Genes and Genomes indicated that some signaling pathways associated with inflammation, immune response, and apoptosis, such as Janus kinase/signal transducers and activators of transcription (Jak-STAT), mitogen-activated protein kinase (MAPK), nuclear factor-κB, and tumor necrosis factor, were all negatively modulated by the 2 strains, especially L. rhamnosus GG. In this paper, we reveal the mechanism of LAB in relieving oxidative stress and provide a theoretical basis for the rapid screening and evaluation of new LAB resources." @default.
- W2955754664 created "2019-07-12" @default.
- W2955754664 creator A5018566178 @default.
- W2955754664 creator A5018796607 @default.
- W2955754664 creator A5020496846 @default.
- W2955754664 creator A5023694096 @default.
- W2955754664 creator A5070959943 @default.
- W2955754664 creator A5080191032 @default.
- W2955754664 creator A5081938339 @default.
- W2955754664 date "2019-09-01" @default.
- W2955754664 modified "2023-10-16" @default.
- W2955754664 title "Transcriptomic responses of Caco-2 cells to Lactobacillus rhamnosus GG and Lactobacillus plantarum J26 against oxidative stress" @default.
- W2955754664 cites W1534435233 @default.
- W2955754664 cites W1923465237 @default.
- W2955754664 cites W1965141776 @default.
- W2955754664 cites W1966554256 @default.
- W2955754664 cites W1967851015 @default.
- W2955754664 cites W1971087663 @default.
- W2955754664 cites W1974940638 @default.
- W2955754664 cites W1975196529 @default.
- W2955754664 cites W1980949357 @default.
- W2955754664 cites W1992390260 @default.
- W2955754664 cites W1994682335 @default.
- W2955754664 cites W1998795148 @default.
- W2955754664 cites W1999536468 @default.
- W2955754664 cites W2002337842 @default.
- W2955754664 cites W2002496108 @default.
- W2955754664 cites W2015392958 @default.
- W2955754664 cites W2020781390 @default.
- W2955754664 cites W2022204196 @default.
- W2955754664 cites W2027979374 @default.
- W2955754664 cites W2033653350 @default.
- W2955754664 cites W2034604842 @default.
- W2955754664 cites W2039556130 @default.
- W2955754664 cites W2047626527 @default.
- W2955754664 cites W2047833751 @default.
- W2955754664 cites W2060049759 @default.
- W2955754664 cites W2063423519 @default.
- W2955754664 cites W2072145140 @default.
- W2955754664 cites W2077926899 @default.
- W2955754664 cites W2081209523 @default.
- W2955754664 cites W2082607103 @default.
- W2955754664 cites W2090393270 @default.
- W2955754664 cites W2097744068 @default.
- W2955754664 cites W2100450490 @default.
- W2955754664 cites W2109491705 @default.
- W2955754664 cites W2113493746 @default.
- W2955754664 cites W2113769639 @default.
- W2955754664 cites W2121303369 @default.
- W2955754664 cites W2124181587 @default.
- W2955754664 cites W2127002905 @default.
- W2955754664 cites W2132991384 @default.
- W2955754664 cites W2135723126 @default.
- W2955754664 cites W2140126848 @default.
- W2955754664 cites W2143095815 @default.
- W2955754664 cites W2143242606 @default.
- W2955754664 cites W2153307836 @default.
- W2955754664 cites W2155149550 @default.
- W2955754664 cites W2159336603 @default.
- W2955754664 cites W2164982726 @default.
- W2955754664 cites W2166482128 @default.
- W2955754664 cites W2171742547 @default.
- W2955754664 cites W2172249877 @default.
- W2955754664 cites W2177757018 @default.
- W2955754664 cites W2313684515 @default.
- W2955754664 cites W2401764291 @default.
- W2955754664 cites W2466580765 @default.
- W2955754664 cites W2524048505 @default.
- W2955754664 cites W2596885909 @default.
- W2955754664 cites W2600709173 @default.
- W2955754664 cites W2612641650 @default.
- W2955754664 cites W2765717831 @default.
- W2955754664 cites W2776513339 @default.
- W2955754664 cites W2804568547 @default.
- W2955754664 doi "https://doi.org/10.3168/jds.2019-16332" @default.
- W2955754664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31255276" @default.
- W2955754664 hasPublicationYear "2019" @default.
- W2955754664 type Work @default.
- W2955754664 sameAs 2955754664 @default.
- W2955754664 citedByCount "16" @default.
- W2955754664 countsByYear W29557546642019 @default.
- W2955754664 countsByYear W29557546642020 @default.
- W2955754664 countsByYear W29557546642021 @default.
- W2955754664 countsByYear W29557546642022 @default.
- W2955754664 countsByYear W29557546642023 @default.
- W2955754664 crossrefType "journal-article" @default.
- W2955754664 hasAuthorship W2955754664A5018566178 @default.
- W2955754664 hasAuthorship W2955754664A5018796607 @default.
- W2955754664 hasAuthorship W2955754664A5020496846 @default.
- W2955754664 hasAuthorship W2955754664A5023694096 @default.
- W2955754664 hasAuthorship W2955754664A5070959943 @default.
- W2955754664 hasAuthorship W2955754664A5080191032 @default.
- W2955754664 hasAuthorship W2955754664A5081938339 @default.
- W2955754664 hasBestOaLocation W29557546641 @default.
- W2955754664 hasConcept C100544194 @default.
- W2955754664 hasConcept C17991360 @default.
- W2955754664 hasConcept C185592680 @default.
- W2955754664 hasConcept C203014093 @default.