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- W2955755537 abstract "Abstract The general stress response (GSR) represents an important trait to survive in the environment by leading to multiple stress resistance. In alphaproteobacteria, the GSR is under the transcriptional control of the alternative sigma factor EcfG. Here we performed transcriptome analyses to investigate the genes controlled by EcfG of Sphingomonas melonis Fr1 and the plasticity of this regulation under stress conditions. We found that EcfG regulates genes for proteins that are typically associated with stress responses. Moreover, EcfG controls regulatory proteins, which likely fine-tune the GSR. Among these, we identified a novel negative GSR feedback regulator, termed NepR2, on the basis of gene reporter assays, phenotypic analyses, and biochemical assays. Transcriptional profiling of signaling components upstream of EcfG under complex stress conditions showed an overall congruence with EcfG-regulated genes. Interestingly however, we found that the GSR is transcriptionally linked to the regulation of motility and biofilm formation via the single domain response regulator SdrG and GSR-activating histidine kinases. Altogether, our findings indicate that the GSR in S. melonis Fr1 underlies a complex regulation to optimize resource allocation and resilience in stressful and changing environments." @default.
- W2955755537 created "2019-07-12" @default.
- W2955755537 creator A5034719272 @default.
- W2955755537 creator A5046847960 @default.
- W2955755537 creator A5073736264 @default.
- W2955755537 creator A5076044886 @default.
- W2955755537 creator A5078183822 @default.
- W2955755537 date "2019-06-28" @default.
- W2955755537 modified "2023-09-26" @default.
- W2955755537 title "Complex general stress response regulation in Sphingomonas melonis Fr1 revealed by transcriptional analyses" @default.
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- W2955755537 doi "https://doi.org/10.1038/s41598-019-45788-7" @default.
- W2955755537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6599016" @default.
- W2955755537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31253827" @default.
- W2955755537 hasPublicationYear "2019" @default.
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