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• W2955761623 startingPage "47" @default.
• W2955761623 abstract "During retrovirus maturation, cleavage of the precursor structural Gag polyprotein by the viral protease induces architectural rearrangement of the virus particle from an immature into a mature, infectious form. The structural rearrangement encapsidates the viral RNA genome in a fullerene capsid, producing a diffusible viral core that can initiate infection upon entry into the cytoplasm of a host cell. Maturation is an important therapeutic window against HIV-1. In this review, we highlight recent breakthroughs in understanding of the structures of retroviral immature and mature capsid lattices that define the boundary conditions of maturation and provide novel insights on capsid transformation. We also discuss emerging insights on encapsidation of the viral genome in the mature capsid, as well as remaining questions for further study." @default.
• W2955761623 created "2019-07-12" @default.
• W2955761623 creator A5015481124 @default.
• W2955761623 creator A5018020732 @default.
• W2955761623 date "2019-06-01" @default.
• W2955761623 modified "2023-09-25" @default.
• W2955761623 title "Maturation of retroviruses" @default.
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