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- W2955763017 endingPage "e474" @default.
- W2955763017 startingPage "e463" @default.
- W2955763017 abstract "Every year, about 1 million people living with HIV worldwide develop tuberculosis. Although the drug regimens used to treat tuberculosis in these patients are the same as those used in HIV-negative patients, cotreatment of tuberculosis with antiretroviral therapy involves challenges including the optimal timing of antiretroviral initiation, drug-drug interactions, drug tolerability, and the prevention and treatment of tuberculosis-associated immune reconstitution syndrome. Furthermore, mortality is high in people with HIV who are diagnosed with tuberculosis during a hospital admission, and in those with tuberculous meningitis. Studies in this field have better characterised these challenges and informed optimal management and guideline revisions. In patients with tuberculosis, antiretroviral therapy improves survival, is well tolerated, and can be adjusted to manage drug-drug interactions with rifampicin. Prednisone is effective in both preventing and treating the paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome." @default.
- W2955763017 created "2019-07-12" @default.
- W2955763017 creator A5009435222 @default.
- W2955763017 creator A5034322602 @default.
- W2955763017 creator A5068645131 @default.
- W2955763017 creator A5084792779 @default.
- W2955763017 date "2019-07-01" @default.
- W2955763017 modified "2023-10-18" @default.
- W2955763017 title "Management of active tuberculosis in adults with HIV" @default.
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- W2955763017 doi "https://doi.org/10.1016/s2352-3018(19)30154-7" @default.
- W2955763017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6750245" @default.
- W2955763017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31272663" @default.