Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955764041> ?p ?o ?g. }
- W2955764041 endingPage "e0219211" @default.
- W2955764041 startingPage "e0219211" @default.
- W2955764041 abstract "Objective Asphyxia of newborns is a severe and frequent challenge of the peri- and postnatal period. The purpose of this study was to study early morphological, immunological and structural alterations in lung tissue after asphyxia and hemorrhage (AH). Methods 44 neonatal piglets (age 32 hrs) underwent asphyxia and hemorrhage (AH) and were treated according to the international liaison committee of resuscitation (ILCOR) guidelines. For this study, 15 piglets (blood transfusion (RBC) n = 9; NaCl n = 6, mean age 31 hrs) were randomly picked. 4 hours after ROSC (return of spontaneous circulation), lung tissue and blood samples were collected. Results An elevation of myeloperoxidase (MPO) activity was observed 4 hrs after AH accompanied by an increase of surfactant D after RBC treatment. After AH tight junction proteins Claudin 18 and junctional adhesion molecule 1 (JAM1) were down-regulated, whereas Occludin was increased. Furthermore, after AH and RBC treatment dephosphorylated active form of Connexin 43 was increased. Conclusions AH in neonatal pigs is associated with early lung injury, inflammation and alterations of tight junctions (Claudin, Occludin, JAM-1) and gap junctions (Connexin 43) in lung tissue, which contributes to the development of lung edema and impaired function." @default.
- W2955764041 created "2019-07-12" @default.
- W2955764041 creator A5007427631 @default.
- W2955764041 creator A5011453746 @default.
- W2955764041 creator A5032763884 @default.
- W2955764041 creator A5044854056 @default.
- W2955764041 creator A5051058935 @default.
- W2955764041 creator A5053545983 @default.
- W2955764041 creator A5067123710 @default.
- W2955764041 creator A5073460097 @default.
- W2955764041 creator A5076741407 @default.
- W2955764041 creator A5081338395 @default.
- W2955764041 creator A5083000854 @default.
- W2955764041 date "2019-07-05" @default.
- W2955764041 modified "2023-09-27" @default.
- W2955764041 title "Lung injury after asphyxia and hemorrhagic shock in newborn piglets: Analysis of structural and inflammatory changes" @default.
- W2955764041 cites W1928848518 @default.
- W2955764041 cites W1988953824 @default.
- W2955764041 cites W2000365029 @default.
- W2955764041 cites W2009828261 @default.
- W2955764041 cites W2015060336 @default.
- W2955764041 cites W2020213576 @default.
- W2955764041 cites W2020510618 @default.
- W2955764041 cites W2023814663 @default.
- W2955764041 cites W2032310708 @default.
- W2955764041 cites W2034073109 @default.
- W2955764041 cites W2041265488 @default.
- W2955764041 cites W2048424386 @default.
- W2955764041 cites W2055763640 @default.
- W2955764041 cites W2068854215 @default.
- W2955764041 cites W2077813077 @default.
- W2955764041 cites W2087394856 @default.
- W2955764041 cites W2089584130 @default.
- W2955764041 cites W2095723461 @default.
- W2955764041 cites W2099944071 @default.
- W2955764041 cites W2106117578 @default.
- W2955764041 cites W2108073477 @default.
- W2955764041 cites W2128825163 @default.
- W2955764041 cites W2130141767 @default.
- W2955764041 cites W2130533068 @default.
- W2955764041 cites W2142999815 @default.
- W2955764041 cites W2148471730 @default.
- W2955764041 cites W2155681517 @default.
- W2955764041 cites W2168020443 @default.
- W2955764041 cites W2170771281 @default.
- W2955764041 cites W2175434751 @default.
- W2955764041 cites W2287619739 @default.
- W2955764041 cites W2351247890 @default.
- W2955764041 cites W2508238260 @default.
- W2955764041 cites W2531816092 @default.
- W2955764041 cites W2620241325 @default.
- W2955764041 cites W2808846578 @default.
- W2955764041 cites W2882563631 @default.
- W2955764041 cites W3215140595 @default.
- W2955764041 doi "https://doi.org/10.1371/journal.pone.0219211" @default.
- W2955764041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6611609" @default.
- W2955764041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31276543" @default.
- W2955764041 hasPublicationYear "2019" @default.
- W2955764041 type Work @default.
- W2955764041 sameAs 2955764041 @default.
- W2955764041 citedByCount "8" @default.
- W2955764041 countsByYear W29557640412021 @default.
- W2955764041 countsByYear W29557640412022 @default.
- W2955764041 crossrefType "journal-article" @default.
- W2955764041 hasAuthorship W2955764041A5007427631 @default.
- W2955764041 hasAuthorship W2955764041A5011453746 @default.
- W2955764041 hasAuthorship W2955764041A5032763884 @default.
- W2955764041 hasAuthorship W2955764041A5044854056 @default.
- W2955764041 hasAuthorship W2955764041A5051058935 @default.
- W2955764041 hasAuthorship W2955764041A5053545983 @default.
- W2955764041 hasAuthorship W2955764041A5067123710 @default.
- W2955764041 hasAuthorship W2955764041A5073460097 @default.
- W2955764041 hasAuthorship W2955764041A5076741407 @default.
- W2955764041 hasAuthorship W2955764041A5081338395 @default.
- W2955764041 hasAuthorship W2955764041A5083000854 @default.
- W2955764041 hasBestOaLocation W29557640411 @default.
- W2955764041 hasConcept C126322002 @default.
- W2955764041 hasConcept C142724271 @default.
- W2955764041 hasConcept C16685009 @default.
- W2955764041 hasConcept C177779419 @default.
- W2955764041 hasConcept C203565725 @default.
- W2955764041 hasConcept C2775962179 @default.
- W2955764041 hasConcept C2776914184 @default.
- W2955764041 hasConcept C2777714996 @default.
- W2955764041 hasConcept C2778165595 @default.
- W2955764041 hasConcept C2779914510 @default.
- W2955764041 hasConcept C2780886150 @default.
- W2955764041 hasConcept C2781300812 @default.
- W2955764041 hasConcept C42219234 @default.
- W2955764041 hasConcept C71924100 @default.
- W2955764041 hasConcept C86803240 @default.
- W2955764041 hasConcept C95444343 @default.
- W2955764041 hasConceptScore W2955764041C126322002 @default.
- W2955764041 hasConceptScore W2955764041C142724271 @default.
- W2955764041 hasConceptScore W2955764041C16685009 @default.
- W2955764041 hasConceptScore W2955764041C177779419 @default.
- W2955764041 hasConceptScore W2955764041C203565725 @default.
- W2955764041 hasConceptScore W2955764041C2775962179 @default.