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• W2955774153 abstract "PURPOSE: The aim of this study was to investigate the impacts of the high intensity interval training (HIIT) on basal autophagy in soleus muscle of rats. METHODS: Nine months old, male Wistar rats were randomly divided in 3 groups: control group (C group, n = 18, sedentary), traditional moderate-intensity continuous training (MICT) group (M group, n = 19, 50-min moderate intensity continuous running at 60% VO2max) and high intensity interval training (HIIT) group (H group, n = 19, 6 bouts ×3 min running at 80% VO2max interspersed with 6 bouts ×3min active recovery at 40% VO2max with a 7-min warm-up and cool down at 60% VO2max) . Before the intervention, a total of 8 rats were killed as the baseline. At the 4th and 8th week, 8 rats of each group were killed 24 h after the last exercise. The test of VO2max, the observation of autophagosome by transmission electron microscope (TEM) and the expression of autophagy-related proteins by western blot were assayed at three time points: baseline, 4th and 8th week after the intervention. Statistical significance was tested by two-way ANOVA. RESULTS: In the 4th week of intervention, compared to the C group, only H group resulted a 30% increase in VO2max (2732.85±135.43 vs. 2103.53±135.43, P<0.01), a 82% increase in the number of autophagosomes (0.50±0.04 vs. 0.28±0.04, P<0.05), a 25% increase in the expression of LC3II (1.62±0.10 vs. 1.29±0.10, P<0.05),no change in the LC3II/LC3I; M group and H group resulted a 38% and 18% decrease respectively in the expression of P62 (0.75±0.05 vs. 0.99±0.05 vs.1.21±0.05, P<0.001, P<0.01) . In the 8th week, compared to the C group, only H group resulted a 30% increase in VO2max (2830.46±135.43 vs. 2182.30±135.43, P<0.05), a 62% increase in the number of autophagosomes (0.53±0.04 vs. 0.33±0.04, P<0.05), a 25% increase in the expression of LC3II (1.79±0.10 vs. 1.43±0.10, P<0.05); a 31% increase in the LC3II/LC3I (2.33±0.12 vs. 1.77±0.12, P<0.01); M group and H group resulted a 26% and 30% decrease respectively in the expression of P62 (0.89±0.05 vs. 0.84±0.05 vs.1.20±0.05, P<0.001, P<0.001 respectively). There was no significant change in the expression of ULK1 Ser757and Beclin-1 in all groups across the training period. CONCLUSION: An engagement in HIIT might promote the basal autophagy activity and autophagy flux,with prominent effects for HIIT than MICT." @default.
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• W2955774153 date "2019-06-01" @default.
• W2955774153 modified "2023-09-26" @default.
• W2955774153 title "The Effects of High Intensity Interval Training on Autophagy in Soleus Muscle of Rats" @default.
• W2955774153 doi "https://doi.org/10.1249/01.mss.0000560936.27962.8c" @default.
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