FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955784444> ?p ?o ?g. }

• W2955784444 endingPage "80" @default.
• W2955784444 startingPage "71" @default.
• W2955784444 abstract "The study objective is to demonstrate the difficulties associated with treatment of HPV-negative oropharyngeal cancer. Material and methods . A 52-year-old male patient visited a doctor in P.A. Herzen Moscow Oncology Research Institute in January 2017 with complaints of pain in the right part of the oropharynx irradiating to the right ear and difficulties with swallowing food and liquids. The patient was diagnosed with stage IVA oropharyngeal cancer (cT3N2bM0). Results. The patient underwent a course chemoradiotherapy (CRT); as a result, the tumor in the area of the right tonsil became indeterminable 2 weeks later. Three months after completing the course of CRT, the patient underwent modified radical right-sided lymph node dissection. Histological examination revealed metastases from poorly differentiated squamous cell carcinoma in 3 lymph nodes (LNs) with an invasion into adjacent adipose tissue. In October 2017, we received a histological confirmation of ongoing tumor growth in the area of the tongue root and LN metastases in the left side of the neck (yrpT4aN2cM0). We performed resection of the mandible, tongue, soft tissues of the oral floor, and right side of the oropharynx with installation of an oropharyngeal stoma, extended radical left-sided neck lym-phadenectomy with excision of soft tissues (levels I—V), defect repair using an autologous pectoral musculocutaneous flap, and tracheostomy. In March 2018, the patient was found to have continuing tumor growth in the area of the epiglottis and floor of the oral cavity. The patient underwent laryngectomy with oropharyngeal resection and end tracheostomy. In July 2018, we again received a histological confirmation of tumor growth in soft tissues of the anterior neck. We performed resection of the tumor and soft tissues with subsequent plastic reconstruction of the defect. In October 2018, the patient presented with multiple metastases in both lungs. He received a course of immune therapy. Positron emission tomography revealed neoplastic foci with pathological metabolic activity in the area of the alveolar process of the mandible (left side), soft tissues of the neck, lungs, left-sided axillary LNs, and mediastinal LNs. It was decided to continue immune therapy. Conclusion. HPV-negative oropharyngeal cancer requires an optimized treatment algorithm and, possibly, more aggressive therapeutic measures, such as increased radiation doses. Both overall management strategy and recommended standard scheme of CRT should be revised; the role of surgical and chemotherapeutic components of treatment should also be reassessed. We believe that surgical intervention should be considered regardless of the effect of radiation therapy, while the duration of follow-up after CRT should be reduced." @default.
• W2955784444 created "2019-07-12" @default.
• W2955784444 creator A5006984381 @default.
• W2955784444 creator A5026725606 @default.
• W2955784444 creator A5041394575 @default.
• W2955784444 creator A5057322959 @default.
• W2955784444 creator A5057444889 @default.
• W2955784444 creator A5073474698 @default.
• W2955784444 creator A5080925298 @default.
• W2955784444 creator A5090269390 @default.
• W2955784444 date "2019-07-02" @default.
• W2955784444 modified "2023-10-06" @default.
• W2955784444 title "HPV-negative oropharyngeal carcinoma as a separate prognostkally unfavorable form of cancer, requiring new approaches to treatment (case report)" @default.
• W2955784444 cites W1757407923 @default.
• W2955784444 cites W1971274526 @default.
• W2955784444 cites W1986241711 @default.
• W2955784444 cites W2131625550 @default.
• W2955784444 cites W2137261097 @default.
• W2955784444 cites W2161649815 @default.
• W2955784444 cites W2758358084 @default.
• W2955784444 cites W2767618986 @default.
• W2955784444 cites W2770931834 @default.
• W2955784444 cites W2889646458 @default.
• W2955784444 cites W2901263658 @default.
• W2955784444 cites W2915034084 @default.
• W2955784444 cites W2885466425 @default.
• W2955784444 doi "https://doi.org/10.17650/2222-1468-2019-9-2-71-80" @default.
• W2955784444 hasPublicationYear "2019" @default.
• W2955784444 type Work @default.
• W2955784444 sameAs 2955784444 @default.
• W2955784444 citedByCount "5" @default.
• W2955784444 countsByYear W29557844442021 @default.
• W2955784444 countsByYear W29557844442022 @default.
• W2955784444 countsByYear W29557844442023 @default.
• W2955784444 crossrefType "journal-article" @default.
• W2955784444 hasAuthorship W2955784444A5006984381 @default.
• W2955784444 hasAuthorship W2955784444A5026725606 @default.
• W2955784444 hasAuthorship W2955784444A5041394575 @default.
• W2955784444 hasAuthorship W2955784444A5057322959 @default.
• W2955784444 hasAuthorship W2955784444A5057444889 @default.
• W2955784444 hasAuthorship W2955784444A5073474698 @default.
• W2955784444 hasAuthorship W2955784444A5080925298 @default.
• W2955784444 hasAuthorship W2955784444A5090269390 @default.
• W2955784444 hasBestOaLocation W29557844441 @default.
• W2955784444 hasConcept C112497637 @default.
• W2955784444 hasConcept C121608353 @default.
• W2955784444 hasConcept C126322002 @default.
• W2955784444 hasConcept C141071460 @default.
• W2955784444 hasConcept C142724271 @default.
• W2955784444 hasConcept C2778424827 @default.
• W2955784444 hasConcept C2778474501 @default.
• W2955784444 hasConcept C2778674591 @default.
• W2955784444 hasConcept C2779419017 @default.
• W2955784444 hasConcept C2779744641 @default.
• W2955784444 hasConcept C2780474809 @default.
• W2955784444 hasConcept C2780849966 @default.
• W2955784444 hasConcept C2781157581 @default.
• W2955784444 hasConcept C509974204 @default.
• W2955784444 hasConcept C71924100 @default.
• W2955784444 hasConceptScore W2955784444C112497637 @default.
• W2955784444 hasConceptScore W2955784444C121608353 @default.
• W2955784444 hasConceptScore W2955784444C126322002 @default.
• W2955784444 hasConceptScore W2955784444C141071460 @default.
• W2955784444 hasConceptScore W2955784444C142724271 @default.
• W2955784444 hasConceptScore W2955784444C2778424827 @default.
• W2955784444 hasConceptScore W2955784444C2778474501 @default.
• W2955784444 hasConceptScore W2955784444C2778674591 @default.
• W2955784444 hasConceptScore W2955784444C2779419017 @default.
• W2955784444 hasConceptScore W2955784444C2779744641 @default.
• W2955784444 hasConceptScore W2955784444C2780474809 @default.
• W2955784444 hasConceptScore W2955784444C2780849966 @default.
• W2955784444 hasConceptScore W2955784444C2781157581 @default.
• W2955784444 hasConceptScore W2955784444C509974204 @default.
• W2955784444 hasConceptScore W2955784444C71924100 @default.
• W2955784444 hasIssue "2" @default.
• W2955784444 hasLocation W29557844441 @default.
• W2955784444 hasOpenAccess W2955784444 @default.
• W2955784444 hasPrimaryLocation W29557844441 @default.
• W2955784444 hasRelatedWork W101894954 @default.
• W2955784444 hasRelatedWork W2006035570 @default.
• W2955784444 hasRelatedWork W2027468941 @default.
• W2955784444 hasRelatedWork W2324867984 @default.
• W2955784444 hasRelatedWork W2369958447 @default.
• W2955784444 hasRelatedWork W2392682289 @default.
• W2955784444 hasRelatedWork W2398896583 @default.
• W2955784444 hasRelatedWork W2415886537 @default.
• W2955784444 hasRelatedWork W2418655945 @default.
• W2955784444 hasRelatedWork W3029157439 @default.
• W2955784444 hasVolume "9" @default.
• W2955784444 isParatext "false" @default.
• W2955784444 isRetracted "false" @default.
• W2955784444 magId "2955784444" @default.
• W2955784444 workType "article" @default.