FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955792011> ?p ?o ?g. }

• W2955792011 endingPage "952" @default.
• W2955792011 startingPage "943" @default.
• W2955792011 abstract "• Mono- and di-rhamnolipids were extracted and purified from a culture of P. aeruginosa MR01. • These compounds showed strong cytoxicity to MCF-7 breast cancer cells. • Cells treated with MR01 rhamnolipids displayed apoptosis changes. • Induction of p53 gene expression in MCF-7 cells treated with MR01 rhamnolipids. Rhamnolipids produced by P. aeruginosa MR01 were fractionated into mono- and di-rhamnolipids, and their dominant congeners, Rha-C 10 -C 10 and Rha-Rha-C 10 -C 10 , were shown by mass spectrometry. Minimum surface tensions and critical micelle concentrations (CMC) were determined as ≃34 mN/m; ≃26.17 mg/l; and ≃29 mN/m; ≃29.63 mg/l for mono- and di-rhamnolipids, respectively. Spectrophotometry measurements provided a close approximation of CMC. Contact angle and diameter of wet area were determined for rhamnolipid-containing drops on hydrophobic paper to display their capability for alteration of surface wettability. Wet area measurement is a simple, reliable method not requiring a Drop Shape Analyzer. Cell viabilities determined by MTT assay showed a decline in a dose-dependent manner and estimated IC 50 values were 25.87 μg/ml and 31.00 μg/ml for mono- and di-rhamnolipids treating MCF-7 cells for 48 h. Morphological observations using the inverted phase-contrast microscopy and fluorescence microscopy via Hoechst staining revealed the apoptotic characteristics in treated MCF-7 cells. The semi-quantitative RT-PCR method demonstrated that expression of the p53 gene in mRNA levels significantly (P < 0.05) increased when treated with 30 μg/ml of each rhamnolipid compound for 12 h. It can be concluded that rhamnolipids derived from MR01 show significant anticancer potential against MCF-7 cell line and should be further investigated as natural, therapeutic anti-tumor agents." @default.
• W2955792011 created "2019-07-12" @default.
• W2955792011 creator A5015628329 @default.
• W2955792011 creator A5026486775 @default.
• W2955792011 creator A5038250676 @default.
• W2955792011 creator A5088584926 @default.
• W2955792011 date "2019-09-01" @default.
• W2955792011 modified "2023-09-24" @default.
• W2955792011 title "Cytotoxic effects of mono- and di-rhamnolipids from Pseudomonas aeruginosa MR01 on MCF-7 human breast cancer cells" @default.
• W2955792011 cites W1483458897 @default.
• W2955792011 cites W1942176292 @default.
• W2955792011 cites W1979077916 @default.
• W2955792011 cites W1987140939 @default.
• W2955792011 cites W1991651757 @default.
• W2955792011 cites W1999800584 @default.
• W2955792011 cites W2000533216 @default.
• W2955792011 cites W2014165289 @default.
• W2955792011 cites W2017251072 @default.
• W2955792011 cites W2019418662 @default.
• W2955792011 cites W2021149289 @default.
• W2955792011 cites W2023623233 @default.
• W2955792011 cites W2044521307 @default.
• W2955792011 cites W2045919907 @default.
• W2955792011 cites W2051005210 @default.
• W2955792011 cites W2053757293 @default.
• W2955792011 cites W2055363096 @default.
• W2955792011 cites W2058650458 @default.
• W2955792011 cites W2068854008 @default.
• W2955792011 cites W2071951795 @default.
• W2955792011 cites W2076518284 @default.
• W2955792011 cites W2082005595 @default.
• W2955792011 cites W2083422792 @default.
• W2955792011 cites W2094044860 @default.
• W2955792011 cites W2119795301 @default.
• W2955792011 cites W2120399463 @default.
• W2955792011 cites W2164120005 @default.
• W2955792011 cites W2164225875 @default.
• W2955792011 cites W2336952365 @default.
• W2955792011 cites W2463989156 @default.
• W2955792011 cites W2469410199 @default.
• W2955792011 cites W2520143290 @default.
• W2955792011 cites W2530310557 @default.
• W2955792011 cites W2540104635 @default.
• W2955792011 cites W2552820307 @default.
• W2955792011 cites W2578562082 @default.
• W2955792011 cites W2588892859 @default.
• W2955792011 cites W2611827085 @default.
• W2955792011 cites W2745482862 @default.
• W2955792011 cites W2763878845 @default.
• W2955792011 cites W2766694056 @default.
• W2955792011 cites W3203096019 @default.
• W2955792011 cites W379961867 @default.
• W2955792011 cites W4229876534 @default.
• W2955792011 doi "https://doi.org/10.1016/j.colsurfb.2019.06.058" @default.
• W2955792011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31382344" @default.
• W2955792011 hasPublicationYear "2019" @default.
• W2955792011 type Work @default.
• W2955792011 sameAs 2955792011 @default.
• W2955792011 citedByCount "37" @default.
• W2955792011 countsByYear W29557920112020 @default.
• W2955792011 countsByYear W29557920112021 @default.
• W2955792011 countsByYear W29557920112022 @default.
• W2955792011 countsByYear W29557920112023 @default.
• W2955792011 crossrefType "journal-article" @default.
• W2955792011 hasAuthorship W2955792011A5015628329 @default.
• W2955792011 hasAuthorship W2955792011A5026486775 @default.
• W2955792011 hasAuthorship W2955792011A5038250676 @default.
• W2955792011 hasAuthorship W2955792011A5088584926 @default.
• W2955792011 hasConcept C109316439 @default.
• W2955792011 hasConcept C109541995 @default.
• W2955792011 hasConcept C11268172 @default.
• W2955792011 hasConcept C121332964 @default.
• W2955792011 hasConcept C121608353 @default.
• W2955792011 hasConcept C13965031 @default.
• W2955792011 hasConcept C147789679 @default.
• W2955792011 hasConcept C153911025 @default.
• W2955792011 hasConcept C169274487 @default.
• W2955792011 hasConcept C184651966 @default.
• W2955792011 hasConcept C185592680 @default.
• W2955792011 hasConcept C190283241 @default.
• W2955792011 hasConcept C192562407 @default.
• W2955792011 hasConcept C202751555 @default.
• W2955792011 hasConcept C2777637488 @default.
• W2955792011 hasConcept C2778549369 @default.
• W2955792011 hasConcept C2780783641 @default.
• W2955792011 hasConcept C2994423619 @default.
• W2955792011 hasConcept C43617362 @default.
• W2955792011 hasConcept C523546767 @default.
• W2955792011 hasConcept C54355233 @default.
• W2955792011 hasConcept C55493867 @default.
• W2955792011 hasConcept C62520636 @default.
• W2955792011 hasConcept C64237528 @default.
• W2955792011 hasConcept C86803240 @default.
• W2955792011 hasConcept C89423630 @default.
• W2955792011 hasConcept C91881484 @default.
• W2955792011 hasConcept C96232424 @default.
• W2955792011 hasConceptScore W2955792011C109316439 @default.
• W2955792011 hasConceptScore W2955792011C109541995 @default.

• next