FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955794509> ?p ?o ?g. }

• W2955794509 endingPage "841" @default.
• W2955794509 startingPage "832" @default.
• W2955794509 abstract "Background While insulin resistance (IR) is associated with specific metabolite signatures in adults, there have been few truly longitudinal studies in healthy children, either to confirm which abnormalities are present, or to determine whether they precede or result from IR. Therefore, we investigated the association of serum metabolites with IR in childhood in the Earlybird cohort. Methods The Earlybird cohort is a well-characterized cohort of healthy children with annual measurements from age 5 to 16 years. For the first time, longitudinal association analyses between individual serum metabolites and homeostatic model assessment (HOMA) of insulin resistance (HOMA-IR) have been performed taking into account the effects of age, growth, puberty, adiposity, and physical activity. Results IR was higher in girls than in boys and was associated with increasing body mass index (BMI). In longitudinal analysis IR was associated with reduced concentrations of branched-chain amino acids (BCAA), 2-ketobutyrate, citrate and 3-hydroxybutyrate, and higher concentrations of lactate and alanine. These findings demonstrate the widespread biochemical consequences of IR for intermediary metabolism, ketogenesis, and pyruvate oxidation during normal child growth and development. Conclusions Longitudinal analysis can differentiate metabolite signatures that precede or follow the development of greater levels of IR. In healthy normal weight children, higher levels of IR are associated with reduced levels of BCAA, ketogenesis, and fuel oxidation. In contrast, elevated lactate concentrations preceded the rise in IR. These changes reveal the metabolite signature of insulin action during normal growth, and they contrast with previous findings in obese children and adults that represent the consequences of IR and obesity." @default.
• W2955794509 created "2019-07-12" @default.
• W2955794509 creator A5016623024 @default.
• W2955794509 creator A5021344018 @default.
• W2955794509 creator A5038195518 @default.
• W2955794509 creator A5048790165 @default.
• W2955794509 creator A5058384301 @default.
• W2955794509 creator A5071097357 @default.
• W2955794509 creator A5079364377 @default.
• W2955794509 creator A5083366423 @default.
• W2955794509 creator A5090668852 @default.
• W2955794509 date "2019-07-11" @default.
• W2955794509 modified "2023-10-18" @default.
• W2955794509 title "Insulin Resistance during normal child growth and development is associated with a distinct blood metabolic phenotype (Earlybird 72)" @default.
• W2955794509 cites W1562810304 @default.
• W2955794509 cites W1623684340 @default.
• W2955794509 cites W1764778685 @default.
• W2955794509 cites W1904064528 @default.
• W2955794509 cites W1931977193 @default.
• W2955794509 cites W1951724000 @default.
• W2955794509 cites W1970283917 @default.
• W2955794509 cites W1986797744 @default.
• W2955794509 cites W1995187187 @default.
• W2955794509 cites W2009568790 @default.
• W2955794509 cites W2016741073 @default.
• W2955794509 cites W2017771330 @default.
• W2955794509 cites W2035218123 @default.
• W2955794509 cites W2035586426 @default.
• W2955794509 cites W2060552707 @default.
• W2955794509 cites W2063433876 @default.
• W2955794509 cites W2066898102 @default.
• W2955794509 cites W2096589896 @default.
• W2955794509 cites W2113468195 @default.
• W2955794509 cites W2126357176 @default.
• W2955794509 cites W2131499497 @default.
• W2955794509 cites W2145665725 @default.
• W2955794509 cites W2148898254 @default.
• W2955794509 cites W2152028368 @default.
• W2955794509 cites W2155128881 @default.
• W2955794509 cites W2160234571 @default.
• W2955794509 cites W2283413659 @default.
• W2955794509 cites W2338627428 @default.
• W2955794509 cites W2382765172 @default.
• W2955794509 cites W2392555039 @default.
• W2955794509 cites W2475990579 @default.
• W2955794509 cites W2564694720 @default.
• W2955794509 cites W2739024746 @default.
• W2955794509 cites W2779711117 @default.
• W2955794509 cites W2784571228 @default.
• W2955794509 cites W2901878590 @default.
• W2955794509 cites W3024284236 @default.
• W2955794509 doi "https://doi.org/10.1111/pedi.12884" @default.
• W2955794509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31254470" @default.
• W2955794509 hasPublicationYear "2019" @default.
• W2955794509 type Work @default.
• W2955794509 sameAs 2955794509 @default.
• W2955794509 citedByCount "14" @default.
• W2955794509 countsByYear W29557945092020 @default.
• W2955794509 countsByYear W29557945092021 @default.
• W2955794509 countsByYear W29557945092022 @default.
• W2955794509 countsByYear W29557945092023 @default.
• W2955794509 crossrefType "journal-article" @default.
• W2955794509 hasAuthorship W2955794509A5016623024 @default.
• W2955794509 hasAuthorship W2955794509A5021344018 @default.
• W2955794509 hasAuthorship W2955794509A5038195518 @default.
• W2955794509 hasAuthorship W2955794509A5048790165 @default.
• W2955794509 hasAuthorship W2955794509A5058384301 @default.
• W2955794509 hasAuthorship W2955794509A5071097357 @default.
• W2955794509 hasAuthorship W2955794509A5079364377 @default.
• W2955794509 hasAuthorship W2955794509A5083366423 @default.
• W2955794509 hasAuthorship W2955794509A5090668852 @default.
• W2955794509 hasBestOaLocation W29557945091 @default.
• W2955794509 hasConcept C126322002 @default.
• W2955794509 hasConcept C134018914 @default.
• W2955794509 hasConcept C135870905 @default.
• W2955794509 hasConcept C2777391703 @default.
• W2955794509 hasConcept C2777477808 @default.
• W2955794509 hasConcept C2778535154 @default.
• W2955794509 hasConcept C2779306644 @default.
• W2955794509 hasConcept C31532488 @default.
• W2955794509 hasConcept C62231903 @default.
• W2955794509 hasConcept C71924100 @default.
• W2955794509 hasConcept C72563966 @default.
• W2955794509 hasConcept C84693403 @default.
• W2955794509 hasConceptScore W2955794509C126322002 @default.
• W2955794509 hasConceptScore W2955794509C134018914 @default.
• W2955794509 hasConceptScore W2955794509C135870905 @default.
• W2955794509 hasConceptScore W2955794509C2777391703 @default.
• W2955794509 hasConceptScore W2955794509C2777477808 @default.
• W2955794509 hasConceptScore W2955794509C2778535154 @default.
• W2955794509 hasConceptScore W2955794509C2779306644 @default.
• W2955794509 hasConceptScore W2955794509C31532488 @default.
• W2955794509 hasConceptScore W2955794509C62231903 @default.
• W2955794509 hasConceptScore W2955794509C71924100 @default.
• W2955794509 hasConceptScore W2955794509C72563966 @default.
• W2955794509 hasConceptScore W2955794509C84693403 @default.
• W2955794509 hasFunder F4320320065 @default.
• W2955794509 hasIssue "7" @default.

• next