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- W2955799373 abstract "To assess the burden of cystic fibrosis (CF), a rare, progressive genetic disease, in infants and children aged <6 years in the US by comparing their health care resource utilization (HCRU) with that of matched individuals without CF. In a retrospective study using US commercial and Medicaid claims databases (2010-2017), patients aged <6 years with CF were matched 1:3 to individuals without CF by age, gender, geographic region, race, enrollment year, and insurance plan type. 1-year HCRU outcomes, including hospitalizations and outpatient medication use, were compared between patients with CF and controls using bivariate statistics for all patients and by age group (infants [aged <2 years] and children aged 2-<6 years). P values <0.05 were considered significant; no multiplicity adjustment was conducted. 835 patients with CF were matched to 2505 controls in the commercial population; 735 patients with CF were matched to 2205 controls in the Medicaid population. Significantly higher HCRU was observed among patients with CF, and more were hospitalized annually versus controls (commercially insured: 15.4% vs. 5.4%; Medicaid-insured: 24.6% vs. 3.1%). Mean annual hospitalization rates were up to 4-fold higher with CF versus controls in the commercially insured population (0.25 vs. 0.06) and 10-fold higher with CF versus controls in the Medicaid-insured population (0.41 vs. 0.04). Similar patterns were observed within age subgroups, where infants and children aged <6 years with CF had significantly higher hospitalization rates versus controls. On average, commercially insured patients aged <6 years with CF had 31.4 total prescription fills/year versus 3.5 for controls; Medicaid-insured patients aged <6 years with CF had 40.9 total prescription fills/year versus 7.0 for controls. P values across all comparisons were <0.05. Infants and children aged <6 years with CF have substantial disease burden with significantly greater hospitalizations and outpatient medication use versus matched controls." @default.
- W2955799373 created "2019-07-12" @default.
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- W2955799373 date "2019-05-01" @default.
- W2955799373 modified "2023-09-30" @default.
- W2955799373 title "PRO26 HEALTH CARE RESOURCE USE AND OUTCOMES AMONG INFANTS AND CHILDREN AGED <6 YEARS WITH CYSTIC FIBROSIS IN THE UNITED STATES" @default.
- W2955799373 doi "https://doi.org/10.1016/j.jval.2019.04.1659" @default.
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