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• W2955799817 abstract "Due to their adjustable physiochemical properties and proven biocompatibility, iron oxide (Fe3O4) magnetic nanoparticles are promising in drug delivery, magnetic resonance imaging and catalysis. In this thesis, we have utilized two types of iron oxide nanoparticles: i) superparamagnetic iron oxide nanoparticles (SPION) for targeted destruction of cancer cells, and ii) poly(N-isopropylacrylamide) (pNIPAM) coated magnetic particles (MNP) for multistage cell separation.SPION are generally considered as drug delivery vehicles for the enhanced permeability and retention (EPR) effect. SPION possess the intrinsic peroxidase-like activity as Horseradish peroxidase (HRP), which can generate reactive oxygen species (ROS) from H2O2 via Fenton’s reaction. ROS regulate cell signaling, but a significant ROS stress can disrupt the redox homeostasis of cancer cells leading to selective tumor cell toxicity and destruction. Hereby, we developed ROS-induced targeted cell destruction with SPION-GOx bioconjugates platform. GOx catalyzes glucose oxidation in cancer cells to produce H2O2. 24 h incubation with 10 μg/mL SPION-GOx on 4T1 cells resulted in almost zero cell viability. In vivo evaluation showed SPION-GOx led to a much slower tumor growth compared to control groups.Additionally, magnetic activated cell sorting (MACS) has become a common technique for the separation of target cell populations from biological suspensions. A major obstacle preventing current single stage MACS from achieving satisfying separation efficiency is the non-specific interactions between the cells and MNP. Thus, we designed a multistage separation platform similar to distillation concept in chemical engineering. The repeated capture-and-release separation process is enabled by attaching the temperature responsive polymer- pNIPAM to both MNP and target cells. We manipulate the reversible hydrophobic-hydrophilic interactions between such functionalized MNP and target cells through temperature cycling to capture and release target cells at a higher efficiency than non-target. After several temperature cycles, target cells are enriched in the product. Flow cytometry results suggest that A431 cells (target) could be effectively separated from HeLa cells (non-target) after three separation stages resulting in an enrichment factor of 3.69 when the starting ratio of target to non-target is 1:2." @default.
• W2955799817 created "2019-07-12" @default.
• W2955799817 creator A5081489394 @default.
• W2955799817 date "2019-06-24" @default.
• W2955799817 modified "2023-09-27" @default.
• W2955799817 title "Study of Iron Oxide Magnetic Nanoparticles in Cancer Cell Destruction and Cell Separation" @default.
• W2955799817 cites W1583123053 @default.
• W2955799817 cites W1649220013 @default.
• W2955799817 cites W1971079720 @default.
• W2955799817 cites W1971106587 @default.
• W2955799817 cites W1973206036 @default.
• W2955799817 cites W1979516675 @default.
• W2955799817 cites W1981984450 @default.
• W2955799817 cites W1981999542 @default.
• W2955799817 cites W1985972866 @default.
• W2955799817 cites W1987615670 @default.
• W2955799817 cites W1987883370 @default.
• W2955799817 cites W1988146848 @default.
• W2955799817 cites W1988272953 @default.
• W2955799817 cites W1990120645 @default.
• W2955799817 cites W1993069899 @default.
• W2955799817 cites W1993219682 @default.
• W2955799817 cites W1994437982 @default.
• W2955799817 cites W1995781927 @default.
• W2955799817 cites W2002516695 @default.
• W2955799817 cites W2008258524 @default.
• W2955799817 cites W2009805582 @default.
• W2955799817 cites W2013021388 @default.
• W2955799817 cites W2016771845 @default.
• W2955799817 cites W2016899305 @default.
• W2955799817 cites W2020318968 @default.
• W2955799817 cites W2021693564 @default.
• W2955799817 cites W2023058305 @default.
• W2955799817 cites W2023768475 @default.
• W2955799817 cites W2024186862 @default.
• W2955799817 cites W2025639351 @default.
• W2955799817 cites W2027390454 @default.
• W2955799817 cites W2027888373 @default.
• W2955799817 cites W2031036131 @default.
• W2955799817 cites W2033007989 @default.
• W2955799817 cites W2034269086 @default.
• W2955799817 cites W2035500973 @default.
• W2955799817 cites W2036614632 @default.
• W2955799817 cites W2038371089 @default.
• W2955799817 cites W2048086807 @default.
• W2955799817 cites W2048452946 @default.
• W2955799817 cites W2048553024 @default.
• W2955799817 cites W2048928172 @default.
• W2955799817 cites W2049889518 @default.
• W2955799817 cites W2051572649 @default.
• W2955799817 cites W2052883298 @default.
• W2955799817 cites W2054745605 @default.
• W2955799817 cites W2055385681 @default.
• W2955799817 cites W2060197999 @default.
• W2955799817 cites W2060420887 @default.
• W2955799817 cites W2061260890 @default.
• W2955799817 cites W2062787494 @default.
• W2955799817 cites W2067087628 @default.
• W2955799817 cites W2069893013 @default.
• W2955799817 cites W2071659125 @default.
• W2955799817 cites W2072238968 @default.
• W2955799817 cites W2075483120 @default.
• W2955799817 cites W2077309466 @default.
• W2955799817 cites W2077673768 @default.
• W2955799817 cites W2084871302 @default.
• W2955799817 cites W2087020662 @default.
• W2955799817 cites W2088641535 @default.
• W2955799817 cites W2090749980 @default.
• W2955799817 cites W2092787533 @default.
• W2955799817 cites W2093827521 @default.
• W2955799817 cites W2096593771 @default.
• W2955799817 cites W2102603826 @default.
• W2955799817 cites W2104492000 @default.
• W2955799817 cites W2106588428 @default.
• W2955799817 cites W2113972541 @default.
• W2955799817 cites W2114760098 @default.
• W2955799817 cites W2116810900 @default.
• W2955799817 cites W2124999157 @default.
• W2955799817 cites W2126346850 @default.
• W2955799817 cites W2126741288 @default.
• W2955799817 cites W2128047109 @default.
• W2955799817 cites W2130977758 @default.
• W2955799817 cites W2132005699 @default.
• W2955799817 cites W2132434084 @default.
• W2955799817 cites W2137820585 @default.
• W2955799817 cites W2141214816 @default.
• W2955799817 cites W2141361677 @default.
• W2955799817 cites W2149273511 @default.
• W2955799817 cites W2154188166 @default.
• W2955799817 cites W2165960269 @default.
• W2955799817 cites W2166280494 @default.
• W2955799817 cites W2167397010 @default.
• W2955799817 cites W2169532237 @default.
• W2955799817 cites W2170913114 @default.
• W2955799817 cites W2174939397 @default.
• W2955799817 cites W2265104901 @default.
• W2955799817 cites W2611800801 @default.
• W2955799817 cites W607105817 @default.
• W2955799817 cites W873561972 @default.
• W2955799817 cites W1979859732 @default.

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