Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955805218> ?p ?o ?g. }
- W2955805218 endingPage "3329" @default.
- W2955805218 startingPage "3329" @default.
- W2955805218 abstract "This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations. These mutations in specific genes generate premature termination codons (PTCs) responsible for the translation of truncated proteins. After a brief introduction on nonsense mutations and their pathological effects, the features of various classes of TRIDs will be described discussing differences or similarities in their mechanisms of action. Strategies to correct the PTCs will be presented, particularly focusing on a new class of Ataluren-like oxadiazole derivatives in comparison to aminoglycosides. Additionally, recent results on the efficiency of new candidate TRIDs in restoring the production of the cystic fibrosis transmembrane regulator (CFTR) protein will be presented. Finally, a prospectus on complementary strategies to enhance the effect of TRIDs will be illustrated together with a conclusive paragraph about perspectives, opportunities, and caveats in developing small molecules as TRIDs." @default.
- W2955805218 created "2019-07-12" @default.
- W2955805218 creator A5012864812 @default.
- W2955805218 creator A5017641442 @default.
- W2955805218 creator A5021841233 @default.
- W2955805218 creator A5049827246 @default.
- W2955805218 creator A5052399683 @default.
- W2955805218 creator A5059892571 @default.
- W2955805218 creator A5074689955 @default.
- W2955805218 date "2019-07-06" @default.
- W2955805218 modified "2023-10-01" @default.
- W2955805218 title "Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs)" @default.
- W2955805218 cites W1964370181 @default.
- W2955805218 cites W1983167449 @default.
- W2955805218 cites W1986316308 @default.
- W2955805218 cites W1994621182 @default.
- W2955805218 cites W1994768667 @default.
- W2955805218 cites W2001134511 @default.
- W2955805218 cites W2005330089 @default.
- W2955805218 cites W2014746879 @default.
- W2955805218 cites W2017412443 @default.
- W2955805218 cites W2018306826 @default.
- W2955805218 cites W2020836286 @default.
- W2955805218 cites W2034972401 @default.
- W2955805218 cites W2047827379 @default.
- W2955805218 cites W2051791025 @default.
- W2955805218 cites W2055197087 @default.
- W2955805218 cites W2055214702 @default.
- W2955805218 cites W2055484555 @default.
- W2955805218 cites W2060084652 @default.
- W2955805218 cites W2060783559 @default.
- W2955805218 cites W2068095506 @default.
- W2955805218 cites W2072554320 @default.
- W2955805218 cites W2076732344 @default.
- W2955805218 cites W2078078890 @default.
- W2955805218 cites W2078790862 @default.
- W2955805218 cites W2084345535 @default.
- W2955805218 cites W2085811948 @default.
- W2955805218 cites W2089536721 @default.
- W2955805218 cites W2094068706 @default.
- W2955805218 cites W2099252894 @default.
- W2955805218 cites W2100252315 @default.
- W2955805218 cites W2104522594 @default.
- W2955805218 cites W2107933391 @default.
- W2955805218 cites W2110952609 @default.
- W2955805218 cites W2114534925 @default.
- W2955805218 cites W2125338916 @default.
- W2955805218 cites W2128903674 @default.
- W2955805218 cites W2131056651 @default.
- W2955805218 cites W2259257293 @default.
- W2955805218 cites W2282411661 @default.
- W2955805218 cites W2289091388 @default.
- W2955805218 cites W2299939977 @default.
- W2955805218 cites W2319304486 @default.
- W2955805218 cites W2418201230 @default.
- W2955805218 cites W2460695091 @default.
- W2955805218 cites W2464888703 @default.
- W2955805218 cites W2507298703 @default.
- W2955805218 cites W2528751872 @default.
- W2955805218 cites W2535126493 @default.
- W2955805218 cites W2536704735 @default.
- W2955805218 cites W2574535868 @default.
- W2955805218 cites W2585983133 @default.
- W2955805218 cites W2612778081 @default.
- W2955805218 cites W2740476818 @default.
- W2955805218 cites W2742346596 @default.
- W2955805218 cites W2743457900 @default.
- W2955805218 cites W2748562726 @default.
- W2955805218 cites W2763301473 @default.
- W2955805218 cites W2767851012 @default.
- W2955805218 cites W2773161660 @default.
- W2955805218 cites W2774187746 @default.
- W2955805218 cites W2780023341 @default.
- W2955805218 cites W2793438195 @default.
- W2955805218 cites W2803612238 @default.
- W2955805218 cites W2805375445 @default.
- W2955805218 cites W2874925241 @default.
- W2955805218 cites W2883337329 @default.
- W2955805218 cites W2894260247 @default.
- W2955805218 cites W2898324042 @default.
- W2955805218 cites W2901134488 @default.
- W2955805218 cites W2906446928 @default.
- W2955805218 cites W2907801841 @default.
- W2955805218 cites W2909207977 @default.
- W2955805218 cites W2910386949 @default.
- W2955805218 cites W2913338833 @default.
- W2955805218 cites W2914753252 @default.
- W2955805218 cites W2916089753 @default.
- W2955805218 cites W2947736898 @default.
- W2955805218 cites W2948314471 @default.
- W2955805218 cites W2949980705 @default.
- W2955805218 cites W2952381320 @default.
- W2955805218 cites W4238098957 @default.
- W2955805218 cites W647583678 @default.
- W2955805218 doi "https://doi.org/10.3390/ijms20133329" @default.
- W2955805218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6651739" @default.
- W2955805218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31284579" @default.
- W2955805218 hasPublicationYear "2019" @default.