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• W2955814112 startingPage "107" @default.
• W2955814112 abstract "Racial and ethnic categories are frequently used in pharmacogenetics literature to stratify patients; however, these categories can be inconsistent across different studies. To address the ongoing debate on the applicability of traditional concepts of race and ethnicity in the context of precision medicine, we aimed to review the application of current racial and ethnic categories in pharmacogenetics and its potential impact on clinical care.One hundred and three total pharmacogenetics papers involving the CYP2C9, CYP2C19, and CYP2D6 genes were analyzed for their country of origin, racial, and ethnic categories used, and allele frequency data. Correspondence between the major continental racial categories promulgated by National Institutes of Health (NIH) and those reported by the pharmacogenetics papers was evaluated.The racial and ethnic categories used in the papers we analyzed were highly heterogeneous. In total, we found 66 different racial and ethnic categories used which fall under the NIH race category White, 47 different racial and ethnic categories for Asian, and 62 different categories for Black. The number of categories used varied widely based on country of origin: Japan used the highest number of different categories for White with 17, Malaysia used the highest number for Asian with 24, and the US used the highest number for Black with 28. Significant variation in allele frequency between different ethnic subgroups was identified within 3 major continental racial categories.Our analysis showed that racial and ethnic classification is highly inconsistent across different papers as well as between different countries. Evidence-based consensus is necessary for optimal use of self-identified race as well as geographical ancestry in pharmacogenetics. Common taxonomy of geographical ancestry which reflects specifics of particular countries and is accepted by the entire scientific community can facilitate reproducible pharmacogenetic research and clinical implementation of its results." @default.
• W2955814112 created "2019-07-12" @default.
• W2955814112 creator A5033775755 @default.
• W2955814112 creator A5086304704 @default.
• W2955814112 date "2019-07-01" @default.
• W2955814112 modified "2023-10-06" @default.
• W2955814112 title "<p>Inconsistency in race and ethnic classification in pharmacogenetics studies and its potential clinical implications</p>" @default.
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