FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955863309> ?p ?o ?g. }

• W2955863309 endingPage "551" @default.
• W2955863309 startingPage "536" @default.
• W2955863309 abstract "Phytic acid (PA) is one of the most common anti-nutritional factors in plant-derived protein feeds, and it poses considerable threats to aquaculture production. However, little is known about the effects of PA on fish intestinal health. This study aimed to investigate the impacts of PA on intestinal immune function in on-growing grass carp. To achieve this goal, a growth trial was conducted for 60 days by feeding 540 fish (120.56 ± 0.51 g) with six semi-purified diets containing graded levels of PA (0, 0.8, 1.6, 2.4, 3.2 and 4.0%). Then fish were challenged with Aeromonas hydrophila for 6 days. The results indicated that, compared with the control group (0% PA), PA did the following: (1) suppressed fish growth performance (percentage weight gain and feed efficiency) and reduced their ability to resist enteritis; (2) decreased fish intestinal antimicrobial ability by reducing intestinal lysozyme (LZ) activities, the contents of complement 3 (C3), C4 and immunoglobulin M (IgM), and downregulating the mRNA levels of hepcidin, liver-expressed antimicrobial peptide 2A (LEAP-2A), LEAP-2B, and β-defensin-1; and (3) aggravated fish intestinal inflammation responses by upregulating the mRNA levels of pro-inflammatory cytokines including tumour necrosis factor α (TNF-α), interleukin 1β (IL-1β) (except in the DI), interferon γ2 (IFN-γ2), IL-8, IL-12p40, IL-15 (except in the DI) and IL-17D, which is partly related to the nuclear factor kappa B (NF-κB) signalling pathway, whereas downregulating the mRNA levels of anti-inflammatory cytokines including transforming growth factor β1 (TGF-β1), IL-4/13A, IL-4/13B, IL-10 and IL-11, which is partially associated with the target of rapamycin (TOR) signalling pathway. The possible reasons for some distinctive gene expression patterns in fish three intestinal segments were discussed. Finally, based on the percent weight gain, enteritis morbidity, IgM content and LZ activity in the PI, the maximum tolerance levels of PA for on-growing grass carp were estimated to be 2.17, 1.68, 1.47 and 1.18% of the diet, respectively." @default.
• W2955863309 created "2019-07-12" @default.
• W2955863309 creator A5015387278 @default.
• W2955863309 creator A5019333444 @default.
• W2955863309 creator A5027278305 @default.
• W2955863309 creator A5030866369 @default.
• W2955863309 creator A5042930226 @default.
• W2955863309 creator A5049926988 @default.
• W2955863309 creator A5050444931 @default.
• W2955863309 creator A5074820309 @default.
• W2955863309 creator A5084940588 @default.
• W2955863309 date "2019-09-01" @default.
• W2955863309 modified "2023-10-15" @default.
• W2955863309 title "Phytic acid disrupted intestinal immune status and suppressed growth performance in on-growing grass carp (Ctenopharyngodon idella)" @default.
• W2955863309 cites W1501881225 @default.
• W2955863309 cites W1512900927 @default.
• W2955863309 cites W1513563151 @default.
• W2955863309 cites W1608842679 @default.
• W2955863309 cites W1898069917 @default.
• W2955863309 cites W1965583590 @default.
• W2955863309 cites W1965597807 @default.
• W2955863309 cites W1966661534 @default.
• W2955863309 cites W1968324296 @default.
• W2955863309 cites W1975176160 @default.
• W2955863309 cites W1979304926 @default.
• W2955863309 cites W1984828591 @default.
• W2955863309 cites W1985366287 @default.
• W2955863309 cites W1985567416 @default.
• W2955863309 cites W1994628487 @default.
• W2955863309 cites W2000805849 @default.
• W2955863309 cites W2001981795 @default.
• W2955863309 cites W2004884143 @default.
• W2955863309 cites W2006750443 @default.
• W2955863309 cites W2007050309 @default.
• W2955863309 cites W2011265605 @default.
• W2955863309 cites W2014308472 @default.
• W2955863309 cites W2020920210 @default.
• W2955863309 cites W2024513761 @default.
• W2955863309 cites W2025802564 @default.
• W2955863309 cites W2030602350 @default.
• W2955863309 cites W2032084728 @default.
• W2955863309 cites W2032413459 @default.
• W2955863309 cites W2035921541 @default.
• W2955863309 cites W2038689206 @default.
• W2955863309 cites W2039014923 @default.
• W2955863309 cites W2042802060 @default.
• W2955863309 cites W2043935380 @default.
• W2955863309 cites W2047508872 @default.
• W2955863309 cites W2051597193 @default.
• W2955863309 cites W2056005135 @default.
• W2955863309 cites W2058852640 @default.
• W2955863309 cites W2061197220 @default.
• W2955863309 cites W2063764478 @default.
• W2955863309 cites W2064162334 @default.
• W2955863309 cites W2071108985 @default.
• W2955863309 cites W2072446592 @default.
• W2955863309 cites W2072628432 @default.
• W2955863309 cites W2074854211 @default.
• W2955863309 cites W2080733338 @default.
• W2955863309 cites W2084381789 @default.
• W2955863309 cites W2090913448 @default.
• W2955863309 cites W2092709778 @default.
• W2955863309 cites W2102567575 @default.
• W2955863309 cites W2105816476 @default.
• W2955863309 cites W2107277218 @default.
• W2955863309 cites W2112815960 @default.
• W2955863309 cites W2121652706 @default.
• W2955863309 cites W2122044177 @default.
• W2955863309 cites W2130983457 @default.
• W2955863309 cites W2132344733 @default.
• W2955863309 cites W2132875879 @default.
• W2955863309 cites W2132980430 @default.
• W2955863309 cites W2138140504 @default.
• W2955863309 cites W2139622515 @default.
• W2955863309 cites W2143045159 @default.
• W2955863309 cites W2147370249 @default.
• W2955863309 cites W2161002194 @default.
• W2955863309 cites W2165267136 @default.
• W2955863309 cites W2167428728 @default.
• W2955863309 cites W218276635 @default.
• W2955863309 cites W2263856609 @default.
• W2955863309 cites W2329345240 @default.
• W2955863309 cites W2344566258 @default.
• W2955863309 cites W2400321904 @default.
• W2955863309 cites W2414268392 @default.
• W2955863309 cites W2498439654 @default.
• W2955863309 cites W2510523517 @default.
• W2955863309 cites W2524329122 @default.
• W2955863309 cites W2578168302 @default.
• W2955863309 cites W2590266314 @default.
• W2955863309 cites W2616867802 @default.
• W2955863309 cites W2619496069 @default.
• W2955863309 cites W2734430558 @default.
• W2955863309 cites W2736862452 @default.
• W2955863309 cites W2747858252 @default.
• W2955863309 cites W2750894984 @default.
• W2955863309 cites W2776759797 @default.
• W2955863309 cites W2792228285 @default.

• next