Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955884908> ?p ?o ?g. }
- W2955884908 abstract "Abstract Purpose Knowledge is limited regarding the prevalence and persistence of chemotherapy‐induced leukoencephalopathy in childhood sarcoma patients. This study explored the presence, clinical relevance, and potential risk factors of leukoencephalopathy in childhood bone and soft tissue sarcoma survivors, treated with intravenous chemotherapy. Methods We acquired cross‐sectional neurocognitive data in adult survivors ( n = 34) (median age at diagnosis [AaD] = 13.32 years, age range = 16‐35 years) and healthy age‐matched controls ( n = 34). Additionally, magnetic resonance imaging included T2‐weighted FLAIR (leukoencephalopathy Fazekas rating), multiexponential T2 relaxation (MET2), and multishell diffusion MRI to estimate myelin integrity‐related metrics and fluid movement restrictions. Finally, chemotherapy subgroups (methotrexate, alkylating agents, or combination), AaD, and Apoε and MTHFRC677T polymorphisms were explored as potential risk factors for leukoencephalopathy. Results At the group level, quality of life, working memory, processing speed, and visual memory were significantly lower in patients compared to controls. Furthermore, long‐term leukoencephalopathy was observed in 27.2% of the childhood sarcoma survivors, which was related to attentional processing speed. Lesions were related to diffusion‐derived, but not to myelin‐sensitive metrics. A significant interaction effect between AaD and chemotherapy group demonstrated more lesions in case of high‐dose methotrexate (HD‐MTX) ( F = 3.434, P = .047). However, patients treated with alkylating agents (without HD‐MTX) also showed lesions in younger patients. Genetic predictors were nonsignificant. Conclusion and implication This study suggests long‐term leukoencephalopathy with possibly underlying changes in vasculature, inflammation, or axonal injury, but not necessarily long‐term demyelination. Such lesions could affect processing speed, and as such long‐term daily life functioning of these patients." @default.
- W2955884908 created "2019-07-12" @default.
- W2955884908 creator A5000110993 @default.
- W2955884908 creator A5000823591 @default.
- W2955884908 creator A5009260771 @default.
- W2955884908 creator A5031780179 @default.
- W2955884908 creator A5050686988 @default.
- W2955884908 creator A5055157144 @default.
- W2955884908 creator A5063372614 @default.
- W2955884908 creator A5071405091 @default.
- W2955884908 creator A5072029514 @default.
- W2955884908 creator A5089548339 @default.
- W2955884908 date "2019-07-05" @default.
- W2955884908 modified "2023-10-09" @default.
- W2955884908 title "Long‐term leukoencephalopathy and neurocognitive functioning in childhood sarcoma patients treated with high‐dose intravenous chemotherapy" @default.
- W2955884908 cites W1900875154 @default.
- W2955884908 cites W1973578742 @default.
- W2955884908 cites W1974937105 @default.
- W2955884908 cites W1982061078 @default.
- W2955884908 cites W1985038074 @default.
- W2955884908 cites W1986269945 @default.
- W2955884908 cites W1986359861 @default.
- W2955884908 cites W1993227273 @default.
- W2955884908 cites W1998072086 @default.
- W2955884908 cites W2001460002 @default.
- W2955884908 cites W2002134187 @default.
- W2955884908 cites W2008606533 @default.
- W2955884908 cites W2012504366 @default.
- W2955884908 cites W2022948823 @default.
- W2955884908 cites W2029305882 @default.
- W2955884908 cites W2029804030 @default.
- W2955884908 cites W2031777531 @default.
- W2955884908 cites W2046378189 @default.
- W2955884908 cites W2053063825 @default.
- W2955884908 cites W2055404511 @default.
- W2955884908 cites W2056804370 @default.
- W2955884908 cites W2074919179 @default.
- W2955884908 cites W2078765772 @default.
- W2955884908 cites W2079090326 @default.
- W2955884908 cites W2085918180 @default.
- W2955884908 cites W2095599995 @default.
- W2955884908 cites W2096988642 @default.
- W2955884908 cites W2098676147 @default.
- W2955884908 cites W2099040516 @default.
- W2955884908 cites W2121572612 @default.
- W2955884908 cites W2122477279 @default.
- W2955884908 cites W2128250086 @default.
- W2955884908 cites W2131940336 @default.
- W2955884908 cites W2144104246 @default.
- W2955884908 cites W2149092213 @default.
- W2955884908 cites W2150037324 @default.
- W2955884908 cites W2156717321 @default.
- W2955884908 cites W2157293741 @default.
- W2955884908 cites W2160028990 @default.
- W2955884908 cites W2175113758 @default.
- W2955884908 cites W2227759345 @default.
- W2955884908 cites W2354343508 @default.
- W2955884908 cites W2409873187 @default.
- W2955884908 cites W2516761392 @default.
- W2955884908 cites W2578570821 @default.
- W2955884908 cites W2593792231 @default.
- W2955884908 cites W2791493931 @default.
- W2955884908 cites W2795084708 @default.
- W2955884908 cites W2805778897 @default.
- W2955884908 cites W2923534420 @default.
- W2955884908 doi "https://doi.org/10.1002/pbc.27893" @default.
- W2955884908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31276297" @default.
- W2955884908 hasPublicationYear "2019" @default.
- W2955884908 type Work @default.
- W2955884908 sameAs 2955884908 @default.
- W2955884908 citedByCount "9" @default.
- W2955884908 countsByYear W29558849082020 @default.
- W2955884908 countsByYear W29558849082021 @default.
- W2955884908 countsByYear W29558849082022 @default.
- W2955884908 countsByYear W29558849082023 @default.
- W2955884908 crossrefType "journal-article" @default.
- W2955884908 hasAuthorship W2955884908A5000110993 @default.
- W2955884908 hasAuthorship W2955884908A5000823591 @default.
- W2955884908 hasAuthorship W2955884908A5009260771 @default.
- W2955884908 hasAuthorship W2955884908A5031780179 @default.
- W2955884908 hasAuthorship W2955884908A5050686988 @default.
- W2955884908 hasAuthorship W2955884908A5055157144 @default.
- W2955884908 hasAuthorship W2955884908A5063372614 @default.
- W2955884908 hasAuthorship W2955884908A5071405091 @default.
- W2955884908 hasAuthorship W2955884908A5072029514 @default.
- W2955884908 hasAuthorship W2955884908A5089548339 @default.
- W2955884908 hasConcept C118552586 @default.
- W2955884908 hasConcept C126322002 @default.
- W2955884908 hasConcept C126838900 @default.
- W2955884908 hasConcept C142724271 @default.
- W2955884908 hasConcept C143409427 @default.
- W2955884908 hasConcept C143998085 @default.
- W2955884908 hasConcept C169900460 @default.
- W2955884908 hasConcept C172467417 @default.
- W2955884908 hasConcept C187212893 @default.
- W2955884908 hasConcept C21963081 @default.
- W2955884908 hasConcept C2776694085 @default.
- W2955884908 hasConcept C2778256501 @default.
- W2955884908 hasConcept C2778336483 @default.
- W2955884908 hasConcept C2778583010 @default.