FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955885749> ?p ?o ?g. }

• W2955885749 endingPage "1237" @default.
• W2955885749 startingPage "1228" @default.
• W2955885749 abstract "Abstract Background: Lung cancer remains the leading cause of cancer mortality with relatively few prognostic biomarkers. We investigated associations with overall survival for telomere length (TL) and genetic variation in chromosome 5p15.33, an established telomere maintenance locus. Methods: Leukocyte TL was measured after diagnosis in 807 patients with non–small cell lung cancer (NSCLC) from the Princess Margaret Cancer Center in Toronto and assessed prospectively in 767 NSCLC cases from the Copenhagen City Heart Study and the Copenhagen General Population Study. Associations with all-cause mortality were tested for 723 variants in 5p15.33, genotyped in 4,672 NSCLC cases. Results: Short telomeres (≤10th percentile) were associated with poor prognosis for adenocarcinoma in both populations: TL measured 6 months after diagnosis [HR = 1.65; 95% confidence intervals (CI), 1.04–2.64] and for those diagnosed within 5 years after blood sampling (HR = 2.42; 95% CI, 1.37–4.28). Short TL was associated with mortality in never smokers with NSCLC (HR = 10.29; 95% CI, 1.86–56.86) and adenocarcinoma (HR = 11.31; 95% CI, 1.96–65.24). Analyses in 5p15.33 identified statistically significant prognostic associations for rs56266421-G in LPCAT1 (HR = 1.86; 95% CI, 1.38–2.52; P = 4.5 × 10−5) in stage I–IIIA NSCLC, and for the SLC6A3 gene with OS in females with NSCLC (P = 1.6 × 10−3). Conclusions: Our findings support the potential clinical utility of TL, particularly for adenocarcinoma patients, while associations in chromosome 5p15.33 warrant further exploration. Impact: This is the largest lung cancer study of leukocyte TL and OS, and the first to examine the impact of the timing of TL measurement. Our findings suggest that extremely short telomeres are indicative of poor prognosis in NSCLC." @default.
• W2955885749 created "2019-07-12" @default.
• W2955885749 creator A5000350877 @default.
• W2955885749 creator A5002857362 @default.
• W2955885749 creator A5012748795 @default.
• W2955885749 creator A5014594202 @default.
• W2955885749 creator A5016899907 @default.
• W2955885749 creator A5019050324 @default.
• W2955885749 creator A5022511267 @default.
• W2955885749 creator A5023531951 @default.
• W2955885749 creator A5028989565 @default.
• W2955885749 creator A5034359692 @default.
• W2955885749 creator A5035243580 @default.
• W2955885749 creator A5036010865 @default.
• W2955885749 creator A5042905421 @default.
• W2955885749 creator A5053712654 @default.
• W2955885749 creator A5055941002 @default.
• W2955885749 creator A5066001988 @default.
• W2955885749 creator A5066957198 @default.
• W2955885749 creator A5069531414 @default.
• W2955885749 creator A5073362806 @default.
• W2955885749 creator A5074808099 @default.
• W2955885749 creator A5075347427 @default.
• W2955885749 creator A5078987010 @default.
• W2955885749 creator A5081350789 @default.
• W2955885749 date "2019-07-01" @default.
• W2955885749 modified "2023-10-16" @default.
• W2955885749 title "Investigation of Leukocyte Telomere Length and Genetic Variants in Chromosome 5p15.33 as Prognostic Markers in Lung Cancer" @default.
• W2955885749 cites W1541877559 @default.
• W2955885749 cites W1757407923 @default.
• W2955885749 cites W1974289191 @default.
• W2955885749 cites W1975905059 @default.
• W2955885749 cites W1977884651 @default.
• W2955885749 cites W2002429822 @default.
• W2955885749 cites W2003048603 @default.
• W2955885749 cites W2010263122 @default.
• W2955885749 cites W2017752436 @default.
• W2955885749 cites W2018838463 @default.
• W2955885749 cites W2023245620 @default.
• W2955885749 cites W2024809912 @default.
• W2955885749 cites W2058649553 @default.
• W2955885749 cites W2062395030 @default.
• W2955885749 cites W2082417571 @default.
• W2955885749 cites W2091500391 @default.
• W2955885749 cites W2097529540 @default.
• W2955885749 cites W2097805950 @default.
• W2955885749 cites W2106675244 @default.
• W2955885749 cites W2107755054 @default.
• W2955885749 cites W2117087331 @default.
• W2955885749 cites W2125734753 @default.
• W2955885749 cites W2126512004 @default.
• W2955885749 cites W2127897870 @default.
• W2955885749 cites W2129418664 @default.
• W2955885749 cites W2134899948 @default.
• W2955885749 cites W2134920290 @default.
• W2955885749 cites W2138741508 @default.
• W2955885749 cites W2145950952 @default.
• W2955885749 cites W2147153626 @default.
• W2955885749 cites W2157237731 @default.
• W2955885749 cites W2159023504 @default.
• W2955885749 cites W2168540867 @default.
• W2955885749 cites W2170250588 @default.
• W2955885749 cites W2195359644 @default.
• W2955885749 cites W2253023849 @default.
• W2955885749 cites W2310516433 @default.
• W2955885749 cites W2325080052 @default.
• W2955885749 cites W2514708596 @default.
• W2955885749 cites W2528850048 @default.
• W2955885749 cites W2566314035 @default.
• W2955885749 cites W2616744155 @default.
• W2955885749 cites W4293719097 @default.
• W2955885749 cites W4297900711 @default.
• W2955885749 doi "https://doi.org/10.1158/1055-9965.epi-18-1215" @default.
• W2955885749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6608599" @default.
• W2955885749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31263055" @default.
• W2955885749 hasPublicationYear "2019" @default.
• W2955885749 type Work @default.
• W2955885749 sameAs 2955885749 @default.
• W2955885749 citedByCount "10" @default.
• W2955885749 countsByYear W29558857492020 @default.
• W2955885749 countsByYear W29558857492021 @default.
• W2955885749 countsByYear W29558857492022 @default.
• W2955885749 countsByYear W29558857492023 @default.
• W2955885749 crossrefType "journal-article" @default.
• W2955885749 hasAuthorship W2955885749A5000350877 @default.
• W2955885749 hasAuthorship W2955885749A5002857362 @default.
• W2955885749 hasAuthorship W2955885749A5012748795 @default.
• W2955885749 hasAuthorship W2955885749A5014594202 @default.
• W2955885749 hasAuthorship W2955885749A5016899907 @default.
• W2955885749 hasAuthorship W2955885749A5019050324 @default.
• W2955885749 hasAuthorship W2955885749A5022511267 @default.
• W2955885749 hasAuthorship W2955885749A5023531951 @default.
• W2955885749 hasAuthorship W2955885749A5028989565 @default.
• W2955885749 hasAuthorship W2955885749A5034359692 @default.
• W2955885749 hasAuthorship W2955885749A5035243580 @default.
• W2955885749 hasAuthorship W2955885749A5036010865 @default.
• W2955885749 hasAuthorship W2955885749A5042905421 @default.
• W2955885749 hasAuthorship W2955885749A5053712654 @default.

• next