FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955886960> ?p ?o ?g. }

• W2955886960 endingPage "532" @default.
• W2955886960 startingPage "528" @default.
• W2955886960 abstract "Background: There are inconsistent findings regarding the relationship between trough whole blood tacrolimus concentration (TAC C 0 ) and acute kidney rejection in recipients undergoing TAC therapeutic drug monitoring (TDM). However, studies have not always assessed TAC C 0 at the time of rejection or accounted for variability in hematocrit. Therefore, this study aimed to investigate the temporal relationship between TAC C 0 and acute rejection, including when accounting for variation in hematocrit. Methods: For 38 recipients who developed biopsy-proven acute rejection (BPAR) in the first 14 days after kidney transplantation, daily TAC C 0 from TDM and hematocrit was collected from case notes. Differences in log 10 -transformed TAC C 0 between the day of BPAR (log C r ), 1 day before BPAR (log C r-1 ), and 2 days before BPAR (log C r-2 ) and the combined median concentrations for the days preceding these (log C prior ) were examined by repeated-measures analysis of variance with Dunnett post hoc testing. Generalized linear mixed-effects regression (glmer) examined the ability of TAC C 0 to predict acute rejection episodes with and without controlling for hematocrit. Results: Log C r-1 [mean difference (95% confidence interval) = −0.13 (−0.21 to −0.048), post hoc P = 0.002] and log C r [−0.13 (−0.24 to −0.025), post hoc P = 0.013] were significantly lower than log C prior . TAC C 0 was a significant ( P = 0.0078) predictor of rejection episodes (area under the receiver operating characteristic curve = 0.79) only in glmer models accounting for variability in hematocrit. Conclusions: In recipients who developed BPAR, there was a significant temporal relationship between TAC C 0 and BPAR incidence under TAC TDM that may not be detected in cross-sectional studies, especially if variability in hematocrit is not addressed. This supports a TAC C 0 –rejection relationship, which differs between recipients, and may explain why some recipients do or do not experience rejection within or below the TDM range, respectively. However, studies with larger sample sizes are needed to confirm this finding." @default.
• W2955886960 created "2019-07-12" @default.
• W2955886960 creator A5046046009 @default.
• W2955886960 creator A5072253049 @default.
• W2955886960 creator A5077900083 @default.
• W2955886960 creator A5079639531 @default.
• W2955886960 creator A5089827696 @default.
• W2955886960 date "2019-08-01" @default.
• W2955886960 modified "2023-09-28" @default.
• W2955886960 title "Is There a Temporal Relationship Between Trough Whole Blood Tacrolimus Concentration and Acute Rejection in the First 14 Days After Kidney Transplantation?" @default.
• W2955886960 cites W1501867239 @default.
• W2955886960 cites W1865099583 @default.
• W2955886960 cites W1891520818 @default.
• W2955886960 cites W1951724000 @default.
• W2955886960 cites W1978362461 @default.
• W2955886960 cites W2025752875 @default.
• W2955886960 cites W2037774211 @default.
• W2955886960 cites W2041808051 @default.
• W2955886960 cites W2042301559 @default.
• W2955886960 cites W2053335334 @default.
• W2955886960 cites W2109138494 @default.
• W2955886960 cites W2145126338 @default.
• W2955886960 cites W2794620936 @default.
• W2955886960 cites W2902458742 @default.
• W2955886960 doi "https://doi.org/10.1097/ftd.0000000000000656" @default.
• W2955886960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31259882" @default.
• W2955886960 hasPublicationYear "2019" @default.
• W2955886960 type Work @default.
• W2955886960 sameAs 2955886960 @default.
• W2955886960 citedByCount "4" @default.
• W2955886960 countsByYear W29558869602020 @default.
• W2955886960 countsByYear W29558869602021 @default.
• W2955886960 crossrefType "journal-article" @default.
• W2955886960 hasAuthorship W2955886960A5046046009 @default.
• W2955886960 hasAuthorship W2955886960A5072253049 @default.
• W2955886960 hasAuthorship W2955886960A5077900083 @default.
• W2955886960 hasAuthorship W2955886960A5079639531 @default.
• W2955886960 hasAuthorship W2955886960A5089827696 @default.
• W2955886960 hasConcept C126322002 @default.
• W2955886960 hasConcept C126894567 @default.
• W2955886960 hasConcept C2780303639 @default.
• W2955886960 hasConcept C2780959883 @default.
• W2955886960 hasConcept C2909675724 @default.
• W2955886960 hasConcept C2911091166 @default.
• W2955886960 hasConcept C44249647 @default.
• W2955886960 hasConcept C58471807 @default.
• W2955886960 hasConcept C71924100 @default.
• W2955886960 hasConcept C76318530 @default.
• W2955886960 hasConceptScore W2955886960C126322002 @default.
• W2955886960 hasConceptScore W2955886960C126894567 @default.
• W2955886960 hasConceptScore W2955886960C2780303639 @default.
• W2955886960 hasConceptScore W2955886960C2780959883 @default.
• W2955886960 hasConceptScore W2955886960C2909675724 @default.
• W2955886960 hasConceptScore W2955886960C2911091166 @default.
• W2955886960 hasConceptScore W2955886960C44249647 @default.
• W2955886960 hasConceptScore W2955886960C58471807 @default.
• W2955886960 hasConceptScore W2955886960C71924100 @default.
• W2955886960 hasConceptScore W2955886960C76318530 @default.
• W2955886960 hasIssue "4" @default.
• W2955886960 hasLocation W29558869601 @default.
• W2955886960 hasLocation W29558869602 @default.
• W2955886960 hasOpenAccess W2955886960 @default.
• W2955886960 hasPrimaryLocation W29558869601 @default.
• W2955886960 hasRelatedWork W2027192467 @default.
• W2955886960 hasRelatedWork W2084149893 @default.
• W2955886960 hasRelatedWork W2149292431 @default.
• W2955886960 hasRelatedWork W2389946526 @default.
• W2955886960 hasRelatedWork W2575925550 @default.
• W2955886960 hasRelatedWork W2584499641 @default.
• W2955886960 hasRelatedWork W3029630957 @default.
• W2955886960 hasRelatedWork W3031138809 @default.
• W2955886960 hasRelatedWork W3083533106 @default.
• W2955886960 hasRelatedWork W4207024715 @default.
• W2955886960 hasVolume "41" @default.
• W2955886960 isParatext "false" @default.
• W2955886960 isRetracted "false" @default.
• W2955886960 magId "2955886960" @default.
• W2955886960 workType "article" @default.