Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955886963> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2955886963 endingPage "S281" @default.
- W2955886963 startingPage "S281" @default.
- W2955886963 abstract "Our study assessed trends in price, market share, and spending of all self-administered multiple sclerosis (MS) disease-modifying specialty medications in Medicare Part D from 2006-2016. Using Medicare Part D claims data, we extracted claims for self-administered MS disease-modifying specialty medications in 2006-2016. For each medication and year, we calculated:1) annual cost of treatment, based on Medicare Part D gross drug cost data and the recommended dosing regimens approved by the FDA;2) market share, defined as the proportion of treatment year equivalents accounted by every drug; and 3) total spending by year per 1,000 Medicare beneficiaries. We further quantified the contribution of Medicare payments, out-of-pocket costs, low-income cost-sharing (LICS)subsidy, coverage gap discounts, and other payments toward total spending. Despite growth of therapeutic options, annual cost of treatment more than quadrupled (2006-2016) from $18,660 to $75,847. Trends in annual costs of treatment with each agent increased in parallel and at very similar rates every year. For instance, annual cost of treatment with Copaxone® increased from $17,924 in 2006 to $36,937 in 2010 to $73,682 in 2016. Similarly, treatment with Avonex® costed $18,563 in 2006, $35,836 in 2010 and $74,958 in 2016. Throughout the study period, Copaxone® had the highest market share, followed by Avonex® and Tecfidera®. Total spending per 1,000 beneficiaries increased by more than 10-fold, from $7,872 in 2006 to $79,411 in 2016. In 2016, Medicare payments accounted for 84.04% of total spending, LICS for 6.19%, out-of-pocket costs for 3.37%, manufacturer coverage gap discounts for 1.74%, and other payments for 4.67%. Annual costs of treatment and drug spending of self-administered MS disease-modifying medications drastically increased over a decade despite the growth of therapeutic options. Increased competition in the specialty drug market does not necessarily translate into price declines. Policies to cap year-over-year inflation in the costs of existing products must be considered." @default.
- W2955886963 created "2019-07-12" @default.
- W2955886963 creator A5008785679 @default.
- W2955886963 creator A5028183261 @default.
- W2955886963 creator A5032962162 @default.
- W2955886963 creator A5060167116 @default.
- W2955886963 creator A5070154039 @default.
- W2955886963 creator A5089117734 @default.
- W2955886963 date "2019-05-01" @default.
- W2955886963 modified "2023-09-26" @default.
- W2955886963 title "PND60 TRENDS IN PRICES AND SPENDING OF SELF-ADMINISTERED DISEASE-MODIFYING SPECIALTY MEDICATIONS FOR THE TREATMENT OF MULTIPLE SCLEROSIS" @default.
- W2955886963 doi "https://doi.org/10.1016/j.jval.2019.04.1333" @default.
- W2955886963 hasPublicationYear "2019" @default.
- W2955886963 type Work @default.
- W2955886963 sameAs 2955886963 @default.
- W2955886963 citedByCount "0" @default.
- W2955886963 crossrefType "journal-article" @default.
- W2955886963 hasAuthorship W2955886963A5008785679 @default.
- W2955886963 hasAuthorship W2955886963A5028183261 @default.
- W2955886963 hasAuthorship W2955886963A5032962162 @default.
- W2955886963 hasAuthorship W2955886963A5060167116 @default.
- W2955886963 hasAuthorship W2955886963A5070154039 @default.
- W2955886963 hasAuthorship W2955886963A5089117734 @default.
- W2955886963 hasBestOaLocation W29558869631 @default.
- W2955886963 hasConcept C10138342 @default.
- W2955886963 hasConcept C118552586 @default.
- W2955886963 hasConcept C126322002 @default.
- W2955886963 hasConcept C144133560 @default.
- W2955886963 hasConcept C145097563 @default.
- W2955886963 hasConcept C159110408 @default.
- W2955886963 hasConcept C160735492 @default.
- W2955886963 hasConcept C162324750 @default.
- W2955886963 hasConcept C20387591 @default.
- W2955886963 hasConcept C2426938 @default.
- W2955886963 hasConcept C2776291444 @default.
- W2955886963 hasConcept C2776680279 @default.
- W2955886963 hasConcept C2777288759 @default.
- W2955886963 hasConcept C2778829437 @default.
- W2955886963 hasConcept C2778858636 @default.
- W2955886963 hasConcept C2780640218 @default.
- W2955886963 hasConcept C34447519 @default.
- W2955886963 hasConcept C50522688 @default.
- W2955886963 hasConcept C512399662 @default.
- W2955886963 hasConcept C71924100 @default.
- W2955886963 hasConcept C84265765 @default.
- W2955886963 hasConcept C98274493 @default.
- W2955886963 hasConceptScore W2955886963C10138342 @default.
- W2955886963 hasConceptScore W2955886963C118552586 @default.
- W2955886963 hasConceptScore W2955886963C126322002 @default.
- W2955886963 hasConceptScore W2955886963C144133560 @default.
- W2955886963 hasConceptScore W2955886963C145097563 @default.
- W2955886963 hasConceptScore W2955886963C159110408 @default.
- W2955886963 hasConceptScore W2955886963C160735492 @default.
- W2955886963 hasConceptScore W2955886963C162324750 @default.
- W2955886963 hasConceptScore W2955886963C20387591 @default.
- W2955886963 hasConceptScore W2955886963C2426938 @default.
- W2955886963 hasConceptScore W2955886963C2776291444 @default.
- W2955886963 hasConceptScore W2955886963C2776680279 @default.
- W2955886963 hasConceptScore W2955886963C2777288759 @default.
- W2955886963 hasConceptScore W2955886963C2778829437 @default.
- W2955886963 hasConceptScore W2955886963C2778858636 @default.
- W2955886963 hasConceptScore W2955886963C2780640218 @default.
- W2955886963 hasConceptScore W2955886963C34447519 @default.
- W2955886963 hasConceptScore W2955886963C50522688 @default.
- W2955886963 hasConceptScore W2955886963C512399662 @default.
- W2955886963 hasConceptScore W2955886963C71924100 @default.
- W2955886963 hasConceptScore W2955886963C84265765 @default.
- W2955886963 hasConceptScore W2955886963C98274493 @default.
- W2955886963 hasLocation W29558869631 @default.
- W2955886963 hasOpenAccess W2955886963 @default.
- W2955886963 hasPrimaryLocation W29558869631 @default.
- W2955886963 hasRelatedWork W1489642244 @default.
- W2955886963 hasRelatedWork W2060737352 @default.
- W2955886963 hasRelatedWork W2186580653 @default.
- W2955886963 hasRelatedWork W2400348376 @default.
- W2955886963 hasRelatedWork W2471411180 @default.
- W2955886963 hasRelatedWork W2736874896 @default.
- W2955886963 hasRelatedWork W2755257389 @default.
- W2955886963 hasRelatedWork W3147616221 @default.
- W2955886963 hasRelatedWork W3148358524 @default.
- W2955886963 hasRelatedWork W3150411697 @default.
- W2955886963 hasVolume "22" @default.
- W2955886963 isParatext "false" @default.
- W2955886963 isRetracted "false" @default.
- W2955886963 magId "2955886963" @default.
- W2955886963 workType "article" @default.