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- W2955886977 abstract "Background Acute hemorrhagic leukoencephalopathy is a rare encephalopathy of unknown etiology, causing fulminant, hemorrhagic central nervous system demyelination with high mortality. It is unclear whether acute hemorrhagic leukoencephalopathy is an entirely distinct entity from acute disseminated encephalomyelitis. Patients and Methods We report two patients with rapidly progressive neurological illness resulting in raised intracranial pressure and coma, with biopsy-proven acute hemorrhagic leukoencephalopathy (perivascular hemorrhages and demyelination, predominantly neutrophil infiltrates). Results Acute cerebrospinal fluid showed pronounced T cell-associated cytokine elevation (interleukins 6, 8, and 17A) and CCL2 or CCL3, higher than in patients with acute disseminated encephalomyelitis, but no B cell-associated cytokine elevation. Conclusion Improved understanding of the immune process may provide rationale for use of anticytokine biologic agents." @default.
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- W2955886977 date "2019-11-01" @default.
- W2955886977 modified "2023-10-15" @default.
- W2955886977 title "Acute Hemorrhagic Leukoencephalopathy: Pathological Features and Cerebrospinal Fluid Cytokine Profiles" @default.
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- W2955886977 doi "https://doi.org/10.1016/j.pediatrneurol.2019.06.013" @default.
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