Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955916488> ?p ?o ?g. }
- W2955916488 abstract "Cells must appropriately sense and integrate multiple metabolic resources to commit to proliferation. Here, we report that S. cerevisiae cells regulate carbon and nitrogen metabolic homeostasis through tRNA U34-thiolation. Despite amino acid sufficiency, tRNA-thiolation deficient cells appear amino acid starved. In these cells, carbon flux towards nucleotide synthesis decreases, and trehalose synthesis increases, resulting in a starvation-like metabolic signature. Thiolation mutants have only minor translation defects. However, in these cells phosphate homeostasis genes are strongly down-regulated, resulting in an effectively phosphate-limited state. Reduced phosphate enforces a metabolic switch, where glucose-6-phosphate is routed towards storage carbohydrates. Notably, trehalose synthesis, which releases phosphate and thereby restores phosphate availability, is central to this metabolic rewiring. Thus, cells use thiolated tRNAs to perceive amino acid sufficiency, balance carbon and amino acid metabolic flux and grow optimally, by controlling phosphate availability. These results further biochemically explain how phosphate availability determines a switch to a ‘starvation-state’." @default.
- W2955916488 created "2019-07-12" @default.
- W2955916488 creator A5005522488 @default.
- W2955916488 creator A5010835569 @default.
- W2955916488 creator A5030427955 @default.
- W2955916488 creator A5052280993 @default.
- W2955916488 creator A5067337083 @default.
- W2955916488 creator A5087749699 @default.
- W2955916488 date "2019-07-01" @default.
- W2955916488 modified "2023-10-16" @default.
- W2955916488 title "A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis" @default.
- W2955916488 cites W1497947649 @default.
- W2955916488 cites W1509046973 @default.
- W2955916488 cites W1519084876 @default.
- W2955916488 cites W1520866295 @default.
- W2955916488 cites W1521067743 @default.
- W2955916488 cites W1607969426 @default.
- W2955916488 cites W1728506611 @default.
- W2955916488 cites W1820624545 @default.
- W2955916488 cites W1830185845 @default.
- W2955916488 cites W1912410317 @default.
- W2955916488 cites W1940863063 @default.
- W2955916488 cites W1967072727 @default.
- W2955916488 cites W1968053288 @default.
- W2955916488 cites W1973686370 @default.
- W2955916488 cites W1995459953 @default.
- W2955916488 cites W1996783999 @default.
- W2955916488 cites W2001357509 @default.
- W2955916488 cites W2003069003 @default.
- W2955916488 cites W2005166958 @default.
- W2955916488 cites W2006734870 @default.
- W2955916488 cites W2008110430 @default.
- W2955916488 cites W2008892277 @default.
- W2955916488 cites W2014900666 @default.
- W2955916488 cites W2016906651 @default.
- W2955916488 cites W2017035524 @default.
- W2955916488 cites W2034162523 @default.
- W2955916488 cites W2036799174 @default.
- W2955916488 cites W2036897871 @default.
- W2955916488 cites W2039279732 @default.
- W2955916488 cites W2040682707 @default.
- W2955916488 cites W2043168428 @default.
- W2955916488 cites W2043811875 @default.
- W2955916488 cites W2050935405 @default.
- W2955916488 cites W2058668641 @default.
- W2955916488 cites W2069772134 @default.
- W2955916488 cites W2073232799 @default.
- W2955916488 cites W2073342442 @default.
- W2955916488 cites W2079517684 @default.
- W2955916488 cites W2081188860 @default.
- W2955916488 cites W2081554913 @default.
- W2955916488 cites W2082907450 @default.
- W2955916488 cites W2083390185 @default.
- W2955916488 cites W2084525210 @default.
- W2955916488 cites W2091627977 @default.
- W2955916488 cites W2098066769 @default.
- W2955916488 cites W2098257366 @default.
- W2955916488 cites W2101807260 @default.
- W2955916488 cites W2102278945 @default.
- W2955916488 cites W2106099205 @default.
- W2955916488 cites W2106311348 @default.
- W2955916488 cites W2106836607 @default.
- W2955916488 cites W2108432720 @default.
- W2955916488 cites W2109535551 @default.
- W2955916488 cites W2110374270 @default.
- W2955916488 cites W2111425514 @default.
- W2955916488 cites W2111813659 @default.
- W2955916488 cites W2112227516 @default.
- W2955916488 cites W2112765717 @default.
- W2955916488 cites W2115430241 @default.
- W2955916488 cites W2116486533 @default.
- W2955916488 cites W2117547188 @default.
- W2955916488 cites W2118084468 @default.
- W2955916488 cites W2128572161 @default.
- W2955916488 cites W2129151536 @default.
- W2955916488 cites W2130337886 @default.
- W2955916488 cites W2134138119 @default.
- W2955916488 cites W2136947295 @default.
- W2955916488 cites W2143753421 @default.
- W2955916488 cites W2145265114 @default.
- W2955916488 cites W2149160678 @default.
- W2955916488 cites W2150235665 @default.
- W2955916488 cites W2152855010 @default.
- W2955916488 cites W2161594264 @default.
- W2955916488 cites W2162357575 @default.
- W2955916488 cites W2167521745 @default.
- W2955916488 cites W2170371323 @default.
- W2955916488 cites W2179438025 @default.
- W2955916488 cites W2337621927 @default.
- W2955916488 cites W2498436110 @default.
- W2955916488 cites W2576890255 @default.
- W2955916488 cites W2585531293 @default.
- W2955916488 cites W2615545356 @default.
- W2955916488 cites W2621281388 @default.
- W2955916488 cites W2708317524 @default.
- W2955916488 cites W2775126148 @default.
- W2955916488 cites W2783867527 @default.
- W2955916488 cites W2793056129 @default.
- W2955916488 cites W2794635962 @default.
- W2955916488 cites W2808878318 @default.