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- W2955932012 abstract "Abstract Based on body weight, morbidly obese leptin-deficient ob/ob mice have less bone than expected, suggesting that leptin plays a role in the skeletal response to weight bearing. To evaluate this possibility, we compared the skeletal response of wild type (WT) and ob/ob mice to hindlimb unloading (HU). Mice were individually housed at 32 °C (thermoneutral) from 4 weeks of age (rapidly growing) to 16 weeks of age (approaching skeletal maturity). Mice were then randomized into one of 4 groups (n = 10/group): (1) WT control, (2) WT HU, (3) ob/ob control, and (4) ob/ob HU and the results analyzed by 2-way ANOVA. ob/ob mice pair-fed to WT mice had normal cancellous bone volume fraction (BV/TV) in distal femur, lower femur length and total bone area, mineral content (BMC) and density (BMD), and higher cancellous bone volume fraction in lumbar vertebra (LV). HU resulted in lower BMC and BMD in total femur, and lower BV/TV in distal femur and LV in both genotypes. Cancellous bone loss in femur in both genotypes was associated with increases in osteoclast-lined bone perimeter. In summary, leptin deficiency did not attenuate HU-induced osteopenia in male mice, suggesting that leptin is not required for bone loss induced by unweighting." @default.
- W2955932012 created "2019-07-12" @default.
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- W2955932012 date "2019-06-27" @default.
- W2955932012 modified "2023-10-16" @default.
- W2955932012 title "Effect of Leptin Deficiency on the Skeletal Response to Hindlimb Unloading in Adult Male Mice" @default.
- W2955932012 cites W1495603145 @default.
- W2955932012 cites W1558241080 @default.
- W2955932012 cites W1567256313 @default.
- W2955932012 cites W182457160 @default.
- W2955932012 cites W1843176375 @default.
- W2955932012 cites W1898281414 @default.
- W2955932012 cites W1900085427 @default.
- W2955932012 cites W1925997092 @default.
- W2955932012 cites W1948228526 @default.
- W2955932012 cites W1955609192 @default.
- W2955932012 cites W1967012185 @default.
- W2955932012 cites W1969531905 @default.
- W2955932012 cites W1970035913 @default.
- W2955932012 cites W1970229070 @default.
- W2955932012 cites W1974503725 @default.
- W2955932012 cites W1976715250 @default.
- W2955932012 cites W1987003441 @default.
- W2955932012 cites W1989709280 @default.
- W2955932012 cites W1990319871 @default.
- W2955932012 cites W1997404862 @default.
- W2955932012 cites W2000914496 @default.
- W2955932012 cites W2001197467 @default.
- W2955932012 cites W2010167659 @default.
- W2955932012 cites W2015795548 @default.
- W2955932012 cites W2017406883 @default.
- W2955932012 cites W2019865723 @default.
- W2955932012 cites W2023358907 @default.
- W2955932012 cites W2023661484 @default.
- W2955932012 cites W2024594848 @default.
- W2955932012 cites W2039047018 @default.
- W2955932012 cites W2039351893 @default.
- W2955932012 cites W2039535804 @default.
- W2955932012 cites W2039913230 @default.
- W2955932012 cites W2040818845 @default.
- W2955932012 cites W2043310079 @default.
- W2955932012 cites W2046449131 @default.
- W2955932012 cites W2047511843 @default.
- W2955932012 cites W2053729671 @default.
- W2955932012 cites W2070361364 @default.
- W2955932012 cites W2070393006 @default.
- W2955932012 cites W2074790166 @default.
- W2955932012 cites W2078753928 @default.
- W2955932012 cites W2087524048 @default.
- W2955932012 cites W2090406095 @default.
- W2955932012 cites W2091192433 @default.
- W2955932012 cites W2091643005 @default.
- W2955932012 cites W2103836609 @default.
- W2955932012 cites W2110802982 @default.
- W2955932012 cites W2117407517 @default.
- W2955932012 cites W2124359549 @default.
- W2955932012 cites W2129706448 @default.
- W2955932012 cites W2139314861 @default.
- W2955932012 cites W2144327775 @default.
- W2955932012 cites W2144746677 @default.
- W2955932012 cites W2151083080 @default.
- W2955932012 cites W2151269199 @default.
- W2955932012 cites W2153201988 @default.
- W2955932012 cites W2163898248 @default.
- W2955932012 cites W2171929497 @default.
- W2955932012 cites W2172083249 @default.
- W2955932012 cites W2176651704 @default.
- W2955932012 cites W2284759896 @default.
- W2955932012 cites W2343236286 @default.
- W2955932012 cites W2343768450 @default.
- W2955932012 cites W2399509978 @default.
- W2955932012 cites W2400856411 @default.
- W2955932012 cites W2403893410 @default.
- W2955932012 cites W2404848505 @default.
- W2955932012 cites W2407171133 @default.
- W2955932012 cites W2473616902 @default.
- W2955932012 cites W2518579383 @default.
- W2955932012 cites W2568438212 @default.
- W2955932012 cites W2605965588 @default.
- W2955932012 cites W2606083073 @default.
- W2955932012 cites W2774969589 @default.
- W2955932012 cites W2790377769 @default.
- W2955932012 cites W2888777544 @default.
- W2955932012 cites W4237205057 @default.
- W2955932012 cites W94140509 @default.
- W2955932012 doi "https://doi.org/10.1038/s41598-019-45587-0" @default.
- W2955932012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6597714" @default.
- W2955932012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31249331" @default.
- W2955932012 hasPublicationYear "2019" @default.
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