FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955961927> ?p ?o ?g. }

• W2955961927 endingPage "3156" @default.
• W2955961927 startingPage "3146" @default.
• W2955961927 abstract "Although the Ub-binding domain in ABIN proteins and NEMO (UBAN) is highly conserved, UBAN-containing proteins exhibit different Ub-binding properties, resulting in their diverse biological roles. Post-translational modifications further control UBAN domain specificity for poly-Ub chains. However, precisely, how the UBAN domain structurally confers such functional diversity remains poorly understood. Here we report crystal structures of ABIN-1 alone and in complex with one or two M1-linked di-Ub chains. ABIN-1 UBAN forms a homo-dimer that provides two symmetrical Ub-binding sites on either side of the coiled-coil structure. Moreover, crystal structures of ABIN1 UBAN in complex with di-Ub chains reveal a concentration-dependency of UBAN/di-Ub binding stoichiometry . Analysis of UBAN/M1-linked di-Ub binding characteristics indicates that phosphorylated S473 in OPTN and its corresponding phospho-mimetic residue in ABIN-1 (E484) are essential for high affinity interactions with M1-linked Ub chains. Also, a phospho-mimetic mutation of A303 in NEMO, corresponding to S473 of OPTN, increases binding affinity for M1-linked Ub chains. These findings are in line with the diverse physiological roles of UBAN domains, as phosphorylation of OPTN UBAN is required to enhance its binding to Ub during mitophagy . • While UBANs are highly conserved domains, they have diverse cellular functions. • ABIN-1 UBAN forms a coiled-coil homo-dimer and binds two M1-linked di-Ubs. • Stoichiometry of UBAN/M1-linked di-Ub binding is concentration-dependent. • Phosphorylation increases affinity of UBANs for M1-linked Ub chains." @default.
• W2955961927 created "2019-07-12" @default.
• W2955961927 creator A5015876762 @default.
• W2955961927 creator A5024202025 @default.
• W2955961927 creator A5033962848 @default.
• W2955961927 creator A5037890241 @default.
• W2955961927 creator A5043378745 @default.
• W2955961927 creator A5082730369 @default.
• W2955961927 creator A5091752129 @default.
• W2955961927 date "2019-08-01" @default.
• W2955961927 modified "2023-10-10" @default.
• W2955961927 title "Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains" @default.
• W2955961927 cites W1539796472 @default.
• W2955961927 cites W1973858832 @default.
• W2955961927 cites W2005986251 @default.
• W2955961927 cites W2006908545 @default.
• W2955961927 cites W2032195857 @default.
• W2955961927 cites W2033703058 @default.
• W2955961927 cites W2038840577 @default.
• W2955961927 cites W2055390996 @default.
• W2955961927 cites W2058094839 @default.
• W2955961927 cites W2061194981 @default.
• W2955961927 cites W2069183779 @default.
• W2955961927 cites W2071703153 @default.
• W2955961927 cites W2073453659 @default.
• W2955961927 cites W2073669171 @default.
• W2955961927 cites W2089793416 @default.
• W2955961927 cites W2094863064 @default.
• W2955961927 cites W2103552916 @default.
• W2955961927 cites W2106140689 @default.
• W2955961927 cites W2125548716 @default.
• W2955961927 cites W2144081223 @default.
• W2955961927 cites W2146080841 @default.
• W2955961927 cites W2153819917 @default.
• W2955961927 cites W2156054547 @default.
• W2955961927 cites W2159211495 @default.
• W2955961927 cites W2166987747 @default.
• W2955961927 cites W2225977638 @default.
• W2955961927 cites W2294344816 @default.
• W2955961927 cites W2323582440 @default.
• W2955961927 cites W239648239 @default.
• W2955961927 cites W2398731353 @default.
• W2955961927 cites W2404280981 @default.
• W2955961927 cites W2491713134 @default.
• W2955961927 cites W2509479781 @default.
• W2955961927 cites W2524809420 @default.
• W2955961927 cites W2558921869 @default.
• W2955961927 cites W2771367425 @default.
• W2955961927 cites W2790198320 @default.
• W2955961927 cites W2799857156 @default.
• W2955961927 cites W2803714880 @default.
• W2955961927 cites W2903082228 @default.
• W2955961927 doi "https://doi.org/10.1016/j.jmb.2019.06.012" @default.
• W2955961927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31247202" @default.
• W2955961927 hasPublicationYear "2019" @default.
• W2955961927 type Work @default.
• W2955961927 sameAs 2955961927 @default.
• W2955961927 citedByCount "15" @default.
• W2955961927 countsByYear W29559619272019 @default.
• W2955961927 countsByYear W29559619272020 @default.
• W2955961927 countsByYear W29559619272021 @default.
• W2955961927 countsByYear W29559619272022 @default.
• W2955961927 countsByYear W29559619272023 @default.
• W2955961927 crossrefType "journal-article" @default.
• W2955961927 hasAuthorship W2955961927A5015876762 @default.
• W2955961927 hasAuthorship W2955961927A5024202025 @default.
• W2955961927 hasAuthorship W2955961927A5033962848 @default.
• W2955961927 hasAuthorship W2955961927A5037890241 @default.
• W2955961927 hasAuthorship W2955961927A5043378745 @default.
• W2955961927 hasAuthorship W2955961927A5082730369 @default.
• W2955961927 hasAuthorship W2955961927A5091752129 @default.
• W2955961927 hasBestOaLocation W29559619272 @default.
• W2955961927 hasConcept C104317684 @default.
• W2955961927 hasConcept C11960822 @default.
• W2955961927 hasConcept C178790620 @default.
• W2955961927 hasConcept C185592680 @default.
• W2955961927 hasConcept C25602115 @default.
• W2955961927 hasConcept C2779546866 @default.
• W2955961927 hasConcept C55493867 @default.
• W2955961927 hasConcept C55988834 @default.
• W2955961927 hasConcept C65556437 @default.
• W2955961927 hasConcept C71240020 @default.
• W2955961927 hasConcept C8010536 @default.
• W2955961927 hasConceptScore W2955961927C104317684 @default.
• W2955961927 hasConceptScore W2955961927C11960822 @default.
• W2955961927 hasConceptScore W2955961927C178790620 @default.
• W2955961927 hasConceptScore W2955961927C185592680 @default.
• W2955961927 hasConceptScore W2955961927C25602115 @default.
• W2955961927 hasConceptScore W2955961927C2779546866 @default.
• W2955961927 hasConceptScore W2955961927C55493867 @default.
• W2955961927 hasConceptScore W2955961927C55988834 @default.
• W2955961927 hasConceptScore W2955961927C65556437 @default.
• W2955961927 hasConceptScore W2955961927C71240020 @default.
• W2955961927 hasConceptScore W2955961927C8010536 @default.
• W2955961927 hasIssue "17" @default.
• W2955961927 hasLocation W29559619271 @default.
• W2955961927 hasLocation W29559619272 @default.
• W2955961927 hasLocation W29559619273 @default.

• next