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• W2955962371 endingPage "206" @default.
• W2955962371 startingPage "197" @default.
• W2955962371 abstract "Pregnane X receptor (PXR, NR1I2) is a prototypical member of the nuclear receptor superfamily. PXR can be activated by both endobiotics and xenobiotics. As a key xenobiotic receptor, the cellular function of PXR is mostly exerted by its binding to the regulatory gene sequences in a ligand-dependent manner. Classical downstream target genes of PXR participate in xenobiotic responses, such as detoxification, metabolism and inflammation. Emerging evidence also implicates PXR signaling in the processes of apoptosis, cell cycle arrest, proliferation, angiogenesis and oxidative stress, which are closely related to cancer. Here, we discussed, in addition to the characterization of PXR per se, the biological function and regulatory mechanism of PXR signaling in cancer, and its potential for the targeted prevention and therapeutics." @default.
• W2955962371 created "2019-07-12" @default.
• W2955962371 creator A5015465130 @default.
• W2955962371 creator A5073521414 @default.
• W2955962371 creator A5084051624 @default.
• W2955962371 date "2020-02-01" @default.
• W2955962371 modified "2023-10-16" @default.
• W2955962371 title "PXR: a center of transcriptional regulation in cancer" @default.
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• W2955962371 doi "https://doi.org/10.1016/j.apsb.2019.06.012" @default.
• W2955962371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7016272" @default.

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