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• W2955963732 abstract "Abstract Background: As the gut microbiome is thought to play a role in the pathogenesis of colorectal carcinoma (CRC), we sought to investigate the patterns of gut microbiota that associate with CRC in a South Asian cohort of patients with CRC. Methods: The relative abundance of 45 types of gut microbial species were determined in faecal samples of CRC patients (n=24), DM (n=20) and healthy age matched controls (n=44), using a PCR array. Data was analyzed using the specific software for analysis of bacterial DNA quantification. Results: The species Bacteroides fragilis (23.9-fold), Bacteroides thetaiotaomicron (8-fold) and Akkermansia muciniphila (5.9-fold) were several-fold over expressed in patients with CRC compared to healthy individuals, whereas bacterial species of the Phylum Proteobacteria were under expressed. There was no difference in the abundance of these 3 species of bacteria with tumour stage or gender and age of patients. Aeromonas species, Enterococcus faecium and Shigella dysenteriae (Proteobacteria) were over 100-fold over abundant in those with DM compared to healthy individuals. Although 70.83% of those with CRC also had diabetes, marked differences were seen between patients with CRC and those with DM. Conclusions: Patients with CRC and DM harbor a markedly different gut microbiota patterns compared to their healthy counterparts. Similar patterns of gut microbial dysbiosis that associate with CRC and DM appear be seen in South Asian populations, compared to Western countries, despite differences in the diet and ethnicity." @default.
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• W2955963732 date "2019-11-19" @default.
• W2955963732 modified "2023-09-25" @default.
• W2955963732 title "Association of the gut microbiota with colorectal cancer in a South Asian cohort of patients" @default.
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• W2955963732 doi "https://doi.org/10.21203/rs.2.17494/v1" @default.
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