FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955983368> ?p ?o ?g. }

• W2955983368 endingPage "687" @default.
• W2955983368 startingPage "678" @default.
• W2955983368 abstract "Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an uncommon hematologic malignancy with poor outcomes. Existing data on the clinical behavior of BPDCN are limited because reported outcomes are from small retrospective series, and standardized treatment guidelines are lacking. The interleukin-3 cytotoxin conjugate tagraxofusp was recently tested in phase 1/2 trials that led to US Food and Drug Administration approval, the first ever for BPDCN. However, because there was no matched internal comparator in this or any clinical study to date, results of BPDCN trials testing new drugs are difficult to compare with alternative therapies. We therefore sought to define the clinical characteristics and outcomes of a group of patients with BPDCN treated at 3 US cancer centers in the modern era but before tagraxofusp was available. In 59 studied patients with BPDCN, the median overall survival from diagnosis was 24 months, and outcomes were similar in patients with “skin only” or with systemic disease at presentation. Intensive first-line therapy and “lymphoid-type” chemotherapy regimens were associated with better outcomes. Only 55% of patients received intensive chemotherapy, and 42% of patients underwent stem cell transplantation. Clinical characteristics at diagnosis associated with poorer outcomes included age &gt;60 years, abnormal karyotype, and terminal deoxynucleotidyltransferase (TdT) negativity in the BPDCN cells. We also identified disease responses to pralatrexate and enasidenib in some patients. This study highlights poor outcomes for patients with BPDCN in the modern era and the need for new treatments. Outcomes from ongoing clinical trials for BPDCN can be evaluated relative to this contemporary cohort." @default.
• W2955983368 created "2019-07-12" @default.
• W2955983368 creator A5001124933 @default.
• W2955983368 creator A5002930435 @default.
• W2955983368 creator A5003947352 @default.
• W2955983368 creator A5009387581 @default.
• W2955983368 creator A5016458162 @default.
• W2955983368 creator A5023485594 @default.
• W2955983368 creator A5024505450 @default.
• W2955983368 creator A5026079585 @default.
• W2955983368 creator A5030353708 @default.
• W2955983368 creator A5063072439 @default.
• W2955983368 creator A5069401963 @default.
• W2955983368 creator A5069406522 @default.
• W2955983368 creator A5071023119 @default.
• W2955983368 creator A5077063317 @default.
• W2955983368 creator A5077875371 @default.
• W2955983368 creator A5081916808 @default.
• W2955983368 creator A5089377441 @default.
• W2955983368 date "2019-08-22" @default.
• W2955983368 modified "2023-10-17" @default.
• W2955983368 title "Multicenter analysis of outcomes in blastic plasmacytoid dendritic cell neoplasm offers a pretargeted therapy benchmark" @default.
• W2955983368 cites W1963511273 @default.
• W2955983368 cites W1978030902 @default.
• W2955983368 cites W1999382249 @default.
• W2955983368 cites W2011741581 @default.
• W2955983368 cites W2021144383 @default.
• W2955983368 cites W2031041045 @default.
• W2955983368 cites W2073408113 @default.
• W2955983368 cites W2080925159 @default.
• W2955983368 cites W2097881820 @default.
• W2955983368 cites W2104240364 @default.
• W2955983368 cites W2107398329 @default.
• W2955983368 cites W2118285663 @default.
• W2955983368 cites W2126972630 @default.
• W2955983368 cites W2140463317 @default.
• W2955983368 cites W2145078955 @default.
• W2955983368 cites W2146112074 @default.
• W2955983368 cites W2147937183 @default.
• W2955983368 cites W2156308068 @default.
• W2955983368 cites W2161984323 @default.
• W2955983368 cites W2191119087 @default.
• W2955983368 cites W2330371366 @default.
• W2955983368 cites W2339658711 @default.
• W2955983368 cites W2521482142 @default.
• W2955983368 cites W2528978902 @default.
• W2955983368 cites W2554471469 @default.
• W2955983368 cites W2564841244 @default.
• W2955983368 cites W2566064140 @default.
• W2955983368 cites W2598250379 @default.
• W2955983368 cites W2605810679 @default.
• W2955983368 cites W2738319672 @default.
• W2955983368 cites W2762525341 @default.
• W2955983368 cites W2765860583 @default.
• W2955983368 cites W2789722062 @default.
• W2955983368 cites W2801670716 @default.
• W2955983368 cites W2804222754 @default.
• W2955983368 cites W2885814296 @default.
• W2955983368 cites W2886660643 @default.
• W2955983368 cites W2888351361 @default.
• W2955983368 cites W2888511806 @default.
• W2955983368 cites W2895867440 @default.
• W2955983368 cites W2899225691 @default.
• W2955983368 cites W2918686807 @default.
• W2955983368 cites W2940782615 @default.
• W2955983368 doi "https://doi.org/10.1182/blood.2019001144" @default.
• W2955983368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6706810" @default.
• W2955983368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31243042" @default.
• W2955983368 hasPublicationYear "2019" @default.
• W2955983368 type Work @default.
• W2955983368 sameAs 2955983368 @default.
• W2955983368 citedByCount "56" @default.
• W2955983368 countsByYear W29559833682019 @default.
• W2955983368 countsByYear W29559833682020 @default.
• W2955983368 countsByYear W29559833682021 @default.
• W2955983368 countsByYear W29559833682022 @default.
• W2955983368 countsByYear W29559833682023 @default.
• W2955983368 crossrefType "journal-article" @default.
• W2955983368 hasAuthorship W2955983368A5001124933 @default.
• W2955983368 hasAuthorship W2955983368A5002930435 @default.
• W2955983368 hasAuthorship W2955983368A5003947352 @default.
• W2955983368 hasAuthorship W2955983368A5009387581 @default.
• W2955983368 hasAuthorship W2955983368A5016458162 @default.
• W2955983368 hasAuthorship W2955983368A5023485594 @default.
• W2955983368 hasAuthorship W2955983368A5024505450 @default.
• W2955983368 hasAuthorship W2955983368A5026079585 @default.
• W2955983368 hasAuthorship W2955983368A5030353708 @default.
• W2955983368 hasAuthorship W2955983368A5063072439 @default.
• W2955983368 hasAuthorship W2955983368A5069401963 @default.
• W2955983368 hasAuthorship W2955983368A5069406522 @default.
• W2955983368 hasAuthorship W2955983368A5071023119 @default.
• W2955983368 hasAuthorship W2955983368A5077063317 @default.
• W2955983368 hasAuthorship W2955983368A5077875371 @default.
• W2955983368 hasAuthorship W2955983368A5081916808 @default.
• W2955983368 hasAuthorship W2955983368A5089377441 @default.
• W2955983368 hasBestOaLocation W29559833681 @default.
• W2955983368 hasConcept C126322002 @default.
• W2955983368 hasConcept C143998085 @default.

• next