Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955983654> ?p ?o ?g. }
- W2955983654 endingPage "821" @default.
- W2955983654 startingPage "811" @default.
- W2955983654 abstract "Growing global viral infections have been a serious public health problem in recent years. This current situation emphasizes the importance of developing more therapeutic antiviral compounds. Hepatitis C virus (HCV) and dengue virus (DENV) belong to the Flaviviridae family and are an increasing global health threat. Our previous study reported that the crude venom of Scorpio maurus palmatus possessed anti-HCV and anti-DENV activities in vitro. We report here the characterization of a natural antiviral peptide (scorpion-like peptide Smp76) that prevents HCV and DENV infection. Smp76 was purified from S. m. palmatus venom and contains 76 amino acids with six residues of cysteine. Smp76 antiviral activity was evaluated using a cell culture technique utilizing Huh7it-1, Vero/SLAM, HCV (JFH1, genotype 2a) and DENV (Trinidad 1751, type 2). A potential antiviral activity of Smp76 was detected in culture cells with an approximate IC50 of 0.01 μg/ml. Moreover, Smp76 prevents HCV infection and suppresses secondary infection, by inactivating extra-cellular infectious particles without affecting viral replication. Interestingly, Smp76 is neither toxic nor hemolytic in vitro at a concentration 1000-fold higher than that required for antiviral activity. Conclusively, this report highlights novel anti-HCV and anti-DENV activities of Smp76, which may lay the foundation for developing a new therapeutic intervention against these flaviviruses." @default.
- W2955983654 created "2019-07-12" @default.
- W2955983654 creator A5001709132 @default.
- W2955983654 creator A5011475413 @default.
- W2955983654 creator A5016710433 @default.
- W2955983654 creator A5030124901 @default.
- W2955983654 creator A5032759906 @default.
- W2955983654 creator A5054062504 @default.
- W2955983654 creator A5061195231 @default.
- W2955983654 creator A5090676005 @default.
- W2955983654 date "2019-07-06" @default.
- W2955983654 modified "2023-10-17" @default.
- W2955983654 title "Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus" @default.
- W2955983654 cites W1825523699 @default.
- W2955983654 cites W1965594747 @default.
- W2955983654 cites W1966722182 @default.
- W2955983654 cites W1970312346 @default.
- W2955983654 cites W1974937986 @default.
- W2955983654 cites W1981537983 @default.
- W2955983654 cites W1984159278 @default.
- W2955983654 cites W1998469753 @default.
- W2955983654 cites W2001852099 @default.
- W2955983654 cites W2003579943 @default.
- W2955983654 cites W2005566891 @default.
- W2955983654 cites W2007058896 @default.
- W2955983654 cites W2011247924 @default.
- W2955983654 cites W2015216410 @default.
- W2955983654 cites W2016961740 @default.
- W2955983654 cites W2018505120 @default.
- W2955983654 cites W2022687771 @default.
- W2955983654 cites W2023101811 @default.
- W2955983654 cites W2023864483 @default.
- W2955983654 cites W2025675035 @default.
- W2955983654 cites W2035893748 @default.
- W2955983654 cites W2039881998 @default.
- W2955983654 cites W2046430692 @default.
- W2955983654 cites W2054602599 @default.
- W2955983654 cites W2055187724 @default.
- W2955983654 cites W2066937610 @default.
- W2955983654 cites W2071997899 @default.
- W2955983654 cites W2072589601 @default.
- W2955983654 cites W2078998316 @default.
- W2955983654 cites W2081798617 @default.
- W2955983654 cites W2081898875 @default.
- W2955983654 cites W2092783239 @default.
- W2955983654 cites W2092998256 @default.
- W2955983654 cites W2094692958 @default.
- W2955983654 cites W2096328031 @default.
- W2955983654 cites W2131222241 @default.
- W2955983654 cites W2152519357 @default.
- W2955983654 cites W2156986452 @default.
- W2955983654 cites W2159861471 @default.
- W2955983654 cites W2187491475 @default.
- W2955983654 cites W2230333060 @default.
- W2955983654 cites W2290337285 @default.
- W2955983654 cites W2318156787 @default.
- W2955983654 cites W2344594906 @default.
- W2955983654 cites W2498263213 @default.
- W2955983654 cites W2580197150 @default.
- W2955983654 cites W2584653841 @default.
- W2955983654 cites W2602169852 @default.
- W2955983654 cites W2760520374 @default.
- W2955983654 cites W2805923773 @default.
- W2955983654 cites W2899548289 @default.
- W2955983654 cites W2901423844 @default.
- W2955983654 cites W438486696 @default.
- W2955983654 doi "https://doi.org/10.1007/s10989-019-09888-2" @default.
- W2955983654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7223391" @default.
- W2955983654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32435168" @default.
- W2955983654 hasPublicationYear "2019" @default.
- W2955983654 type Work @default.
- W2955983654 sameAs 2955983654 @default.
- W2955983654 citedByCount "21" @default.
- W2955983654 countsByYear W29559836542019 @default.
- W2955983654 countsByYear W29559836542020 @default.
- W2955983654 countsByYear W29559836542021 @default.
- W2955983654 countsByYear W29559836542022 @default.
- W2955983654 countsByYear W29559836542023 @default.
- W2955983654 crossrefType "journal-article" @default.
- W2955983654 hasAuthorship W2955983654A5001709132 @default.
- W2955983654 hasAuthorship W2955983654A5011475413 @default.
- W2955983654 hasAuthorship W2955983654A5016710433 @default.
- W2955983654 hasAuthorship W2955983654A5030124901 @default.
- W2955983654 hasAuthorship W2955983654A5032759906 @default.
- W2955983654 hasAuthorship W2955983654A5054062504 @default.
- W2955983654 hasAuthorship W2955983654A5061195231 @default.
- W2955983654 hasAuthorship W2955983654A5090676005 @default.
- W2955983654 hasBestOaLocation W29559836541 @default.
- W2955983654 hasConcept C159047783 @default.
- W2955983654 hasConcept C2522874641 @default.
- W2955983654 hasConcept C2776408679 @default.
- W2955983654 hasConcept C2777510210 @default.
- W2955983654 hasConcept C2779281246 @default.
- W2955983654 hasConcept C2779635636 @default.
- W2955983654 hasConcept C2781463415 @default.
- W2955983654 hasConcept C533803919 @default.
- W2955983654 hasConcept C55493867 @default.
- W2955983654 hasConcept C86803240 @default.