FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955984881> ?p ?o ?g. }

• W2955984881 endingPage "825" @default.
• W2955984881 startingPage "813" @default.
• W2955984881 abstract "Biological membranes carry fixed charges at their surfaces. These arise primarily from phospholipid headgroups. In addition, membrane proteins contribute to the surface potential with their charged residues. Membrane lipids are asymmetrically distributed. Because of this asymmetry, the net-negative charge at the inner leaflet exceeds that at the outer leaflet. Changes in surface potential are predicted to give rise to apparent changes in membrane capacitance. Here, we show that it is possible to detect changes in surface potential by an electrophysiological approach; the analysis of cellular currents relies on assuming that the electrical properties of a cell are faithfully described by a three-element circuit (i.e., the minimal equivalent circuit) comprised of two resistors and one capacitor. However, to account for changes in surface potential, it is necessary to add a battery to this circuit connected in series with the capacitor. This extended circuit model predicts that the current response to a square-wave voltage pulse harbors information, which allows for separating the changes in surface potential from a true capacitance change. We interrogated our model by investigating changes in the capacitance induced by ligand binding to the serotonin transporter and to the glycine transporters (GlyT1 and GlyT2). The experimental observations were consistent with the predictions of the extended circuit. We conclude that ligand-induced changes in surface potential (reflecting the binding event) and in true membrane capacitance (reflecting the concomitant conformational change) can be detected in real time even in instances in which they occur simultaneously." @default.
• W2955984881 created "2019-07-12" @default.
• W2955984881 creator A5037291845 @default.
• W2955984881 creator A5060360807 @default.
• W2955984881 creator A5086541043 @default.
• W2955984881 creator A5088162073 @default.
• W2955984881 date "2020-02-01" @default.
• W2955984881 modified "2023-10-11" @default.
• W2955984881 title "An Electrophysiological Approach to Measure Changes in the Membrane Surface Potential in Real Time" @default.
• W2955984881 cites W1507101079 @default.
• W2955984881 cites W1762647466 @default.
• W2955984881 cites W1970249565 @default.
• W2955984881 cites W1973995482 @default.
• W2955984881 cites W1990973079 @default.
• W2955984881 cites W1992403232 @default.
• W2955984881 cites W1999208340 @default.
• W2955984881 cites W2015199368 @default.
• W2955984881 cites W2020627996 @default.
• W2955984881 cites W2022968719 @default.
• W2955984881 cites W2028069387 @default.
• W2955984881 cites W2036074296 @default.
• W2955984881 cites W2050453104 @default.
• W2955984881 cites W2056671004 @default.
• W2955984881 cites W2061309176 @default.
• W2955984881 cites W2068578978 @default.
• W2955984881 cites W2086908771 @default.
• W2955984881 cites W2092544515 @default.
• W2955984881 cites W2119572656 @default.
• W2955984881 cites W2123146696 @default.
• W2955984881 cites W2132064312 @default.
• W2955984881 cites W2138373663 @default.
• W2955984881 cites W2146686098 @default.
• W2955984881 cites W2147762728 @default.
• W2955984881 cites W2416351033 @default.
• W2955984881 cites W2768031183 @default.
• W2955984881 cites W2770487820 @default.
• W2955984881 cites W2784697727 @default.
• W2955984881 cites W2955818056 @default.
• W2955984881 cites W2977770604 @default.
• W2955984881 cites W4232988224 @default.
• W2955984881 doi "https://doi.org/10.1016/j.bpj.2019.06.033" @default.
• W2955984881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7036697" @default.
• W2955984881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31409481" @default.
• W2955984881 hasPublicationYear "2020" @default.
• W2955984881 type Work @default.
• W2955984881 sameAs 2955984881 @default.
• W2955984881 citedByCount "4" @default.
• W2955984881 countsByYear W29559848812021 @default.
• W2955984881 countsByYear W29559848812022 @default.
• W2955984881 countsByYear W29559848812023 @default.
• W2955984881 crossrefType "journal-article" @default.
• W2955984881 hasAuthorship W2955984881A5037291845 @default.
• W2955984881 hasAuthorship W2955984881A5060360807 @default.
• W2955984881 hasAuthorship W2955984881A5086541043 @default.
• W2955984881 hasAuthorship W2955984881A5088162073 @default.
• W2955984881 hasBestOaLocation W29559848811 @default.
• W2955984881 hasConcept C12554922 @default.
• W2955984881 hasConcept C147789679 @default.
• W2955984881 hasConcept C169760540 @default.
• W2955984881 hasConcept C17525397 @default.
• W2955984881 hasConcept C181911157 @default.
• W2955984881 hasConcept C185263204 @default.
• W2955984881 hasConcept C185592680 @default.
• W2955984881 hasConcept C186060115 @default.
• W2955984881 hasConcept C30066665 @default.
• W2955984881 hasConcept C39944091 @default.
• W2955984881 hasConcept C41625074 @default.
• W2955984881 hasConcept C55493867 @default.
• W2955984881 hasConcept C86803240 @default.
• W2955984881 hasConceptScore W2955984881C12554922 @default.
• W2955984881 hasConceptScore W2955984881C147789679 @default.
• W2955984881 hasConceptScore W2955984881C169760540 @default.
• W2955984881 hasConceptScore W2955984881C17525397 @default.
• W2955984881 hasConceptScore W2955984881C181911157 @default.
• W2955984881 hasConceptScore W2955984881C185263204 @default.
• W2955984881 hasConceptScore W2955984881C185592680 @default.
• W2955984881 hasConceptScore W2955984881C186060115 @default.
• W2955984881 hasConceptScore W2955984881C30066665 @default.
• W2955984881 hasConceptScore W2955984881C39944091 @default.
• W2955984881 hasConceptScore W2955984881C41625074 @default.
• W2955984881 hasConceptScore W2955984881C55493867 @default.
• W2955984881 hasConceptScore W2955984881C86803240 @default.
• W2955984881 hasFunder F4320321003 @default.
• W2955984881 hasFunder F4320321181 @default.
• W2955984881 hasIssue "4" @default.
• W2955984881 hasLocation W29559848811 @default.
• W2955984881 hasLocation W29559848812 @default.
• W2955984881 hasLocation W29559848813 @default.
• W2955984881 hasOpenAccess W2955984881 @default.
• W2955984881 hasPrimaryLocation W29559848811 @default.
• W2955984881 hasRelatedWork W1988917127 @default.
• W2955984881 hasRelatedWork W1995706914 @default.
• W2955984881 hasRelatedWork W2051337061 @default.
• W2955984881 hasRelatedWork W2052531890 @default.
• W2955984881 hasRelatedWork W2055830121 @default.
• W2955984881 hasRelatedWork W2159105851 @default.
• W2955984881 hasRelatedWork W2161536338 @default.
• W2955984881 hasRelatedWork W2351270862 @default.

• next