FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955985228> ?p ?o ?g. }

• W2955985228 endingPage "694" @default.
• W2955985228 startingPage "677" @default.
• W2955985228 abstract "The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex. Complement activation liberates the anaphylatoxins C3a and C5a, which activate three distinct G-protein coupled receptors, C3aR, C5aR1 and C5aR2 (anaphylatoxin receptors, ATRs). We recently discovered that C5aR1 exacerbates the course of the disease, revealing a downside of complement in Nme sepsis. Here, we compared the roles of all three ATRs during mouse nasal colonization, intraperitoneal infection and human whole blood infection with Nme. Deficiency of complement or ATRs did not alter nasal colonization, but significantly affected invasive disease: Compared to WT mice, the disease was aggravated in C3ar−/- mice, whereas C5ar1−/- and C5ar2−/- mice showed increased resistance to meningococcal sepsis. Surprisingly, deletion of either of the ATRs resulted in lower cytokine/chemokine responses, irrespective of the different susceptibilities of the mice. This was similar in ex vivo human whole blood infection using ATR inhibitors. Neutrophil responses to Nme were reduced in C5ar1−/- mouse blood. Upon stimulation with C5a plus Nme, mouse macrophages displayed reduced phosphorylation of ERK1/2, when C5aR1 or C5aR2 were ablated or inhibited, suggesting that both C5a-receptors prime an initial macrophage response to Nme. Finally, in vivo blockade of C5aR1 alone (PMX205) or along with C5aR2 (A8Δ71−73) resulted in ameliorated disease, whereas neither antagonizing C3aR (SB290157) nor its activation with a “super-agonist” peptide (WWGKKYRASKLGLAR) demonstrated a benefit. Thus, C5aR1 and C5aR2 augment disease pathology and are interesting targets for treatment, whereas C3aR is protective in experimental meningococcal sepsis." @default.
• W2955985228 created "2019-07-12" @default.
• W2955985228 creator A5005325608 @default.
• W2955985228 creator A5010098251 @default.
• W2955985228 creator A5036024378 @default.
• W2955985228 creator A5048940037 @default.
• W2955985228 creator A5055017065 @default.
• W2955985228 creator A5070522081 @default.
• W2955985228 creator A5091556449 @default.
• W2955985228 date "2019-01-01" @default.
• W2955985228 modified "2023-10-14" @default.
• W2955985228 title "Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections" @default.
• W2955985228 cites W121366242 @default.
• W2955985228 cites W1486872989 @default.
• W2955985228 cites W1546400353 @default.
• W2955985228 cites W1645772311 @default.
• W2955985228 cites W1751228691 @default.
• W2955985228 cites W1941186790 @default.
• W2955985228 cites W1969191676 @default.
• W2955985228 cites W1971790247 @default.
• W2955985228 cites W1974955870 @default.
• W2955985228 cites W1979452162 @default.
• W2955985228 cites W1993497753 @default.
• W2955985228 cites W1995574274 @default.
• W2955985228 cites W2003590292 @default.
• W2955985228 cites W2005977813 @default.
• W2955985228 cites W2010038769 @default.
• W2955985228 cites W2010175077 @default.
• W2955985228 cites W2013339063 @default.
• W2955985228 cites W2015420183 @default.
• W2955985228 cites W2017566024 @default.
• W2955985228 cites W2018831327 @default.
• W2955985228 cites W2022895689 @default.
• W2955985228 cites W2024242455 @default.
• W2955985228 cites W2024875771 @default.
• W2955985228 cites W2034345422 @default.
• W2955985228 cites W2043825921 @default.
• W2955985228 cites W2049071821 @default.
• W2955985228 cites W2053443014 @default.
• W2955985228 cites W2055585500 @default.
• W2955985228 cites W2056241473 @default.
• W2955985228 cites W2056876225 @default.
• W2955985228 cites W2058801584 @default.
• W2955985228 cites W2060923435 @default.
• W2955985228 cites W2064235503 @default.
• W2955985228 cites W2065033987 @default.
• W2955985228 cites W2065760147 @default.
• W2955985228 cites W2072212601 @default.
• W2955985228 cites W2083175247 @default.
• W2955985228 cites W2084231381 @default.
• W2955985228 cites W2085445504 @default.
• W2955985228 cites W2086841832 @default.
• W2955985228 cites W2089442372 @default.
• W2955985228 cites W2093996346 @default.
• W2955985228 cites W2096532993 @default.
• W2955985228 cites W2097972374 @default.
• W2955985228 cites W2102537411 @default.
• W2955985228 cites W2102809922 @default.
• W2955985228 cites W2112372337 @default.
• W2955985228 cites W2113042039 @default.
• W2955985228 cites W2113183663 @default.
• W2955985228 cites W2119311047 @default.
• W2955985228 cites W2120908238 @default.
• W2955985228 cites W2123156974 @default.
• W2955985228 cites W2129537774 @default.
• W2955985228 cites W2133008646 @default.
• W2955985228 cites W2138178072 @default.
• W2955985228 cites W2151486736 @default.
• W2955985228 cites W2166663556 @default.
• W2955985228 cites W2167870644 @default.
• W2955985228 cites W2169412596 @default.
• W2955985228 cites W2169958703 @default.
• W2955985228 cites W22231059 @default.
• W2955985228 cites W2274886384 @default.
• W2955985228 cites W2321425062 @default.
• W2955985228 cites W2337492903 @default.
• W2955985228 cites W2340057603 @default.
• W2955985228 cites W2410491620 @default.
• W2955985228 cites W2593164312 @default.
• W2955985228 cites W2625214851 @default.
• W2955985228 cites W2625982645 @default.
• W2955985228 cites W2705109811 @default.
• W2955985228 cites W2785907535 @default.
• W2955985228 cites W2792335057 @default.
• W2955985228 cites W2803960610 @default.
• W2955985228 cites W2809827390 @default.
• W2955985228 cites W2901872087 @default.
• W2955985228 cites W2921148887 @default.
• W2955985228 cites W4234783518 @default.
• W2955985228 cites W4235898601 @default.
• W2955985228 cites W4249066710 @default.
• W2955985228 cites W1993507524 @default.
• W2955985228 doi "https://doi.org/10.1080/21505594.2019.1640035" @default.
• W2955985228 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6650196" @default.
• W2955985228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31274379" @default.
• W2955985228 hasPublicationYear "2019" @default.
• W2955985228 type Work @default.
• W2955985228 sameAs 2955985228 @default.

• next