FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955989987> ?p ?o ?g. }

• W2955989987 abstract "The addition of matrix formers within a formulation provides a means for enhancing the redispersibility of nanoparticles (NPs) enabling them to retain their advantageous properties imparted onto them by their sub-micron size. In this work, NPs were isolated in the solid state via spray drying with a range of sugars. The processed powders were characterized, establishing that itraconazole (ITR) nanostructured microparticles (NMPs) spray dried in the presence of mannitol and trehalose had favorable redispersibility confirmed by dynamic light scattering and nanoparticle tracking analysis. Solid-state analysis confirmed the crystalline nature of NMPs based on mannitol and the amorphous character of trehalose-based NMPs. The NMPs powders were compacted at a range of pressures, producing tablets with high tensile strength without compromising their disintegration time. A greater amount of ITR was solubilized from trehalose NMPs compared to the mannitol-based compacts in 0.1 M HCl, showing a promise for enhanced in vivo activity. Overall, as trehalose exhibited superior carrier properties for ITR NMPs, this type of excipient included in the formulation warrants careful consideration. The structured approach to matrix former selection and tabletting studies can reduce the amount of material and time required for testing in the initial stages of product development." @default.
• W2955989987 created "2019-07-12" @default.
• W2955989987 creator A5016295045 @default.
• W2955989987 creator A5018805784 @default.
• W2955989987 creator A5073383878 @default.
• W2955989987 date "2019-06-06" @default.
• W2955989987 modified "2023-10-06" @default.
• W2955989987 title "Isolation of Itraconazole Nanostructured Microparticles via Spray Drying with Rational Selection of Optimum Base for Successful Reconstitution and Compaction" @default.
• W2955989987 cites W1195955210 @default.
• W2955989987 cites W1207375253 @default.
• W2955989987 cites W1967454217 @default.
• W2955989987 cites W1971405219 @default.
• W2955989987 cites W1972646815 @default.
• W2955989987 cites W1976172634 @default.
• W2955989987 cites W1981679395 @default.
• W2955989987 cites W1981985195 @default.
• W2955989987 cites W1986769022 @default.
• W2955989987 cites W1996338454 @default.
• W2955989987 cites W1998828856 @default.
• W2955989987 cites W2001110456 @default.
• W2955989987 cites W2001596955 @default.
• W2955989987 cites W2002038372 @default.
• W2955989987 cites W2002528172 @default.
• W2955989987 cites W2005663182 @default.
• W2955989987 cites W2006094625 @default.
• W2955989987 cites W2012839468 @default.
• W2955989987 cites W2012929504 @default.
• W2955989987 cites W2017919542 @default.
• W2955989987 cites W2035035846 @default.
• W2955989987 cites W2037004764 @default.
• W2955989987 cites W2060298851 @default.
• W2955989987 cites W2062346329 @default.
• W2955989987 cites W2063288695 @default.
• W2955989987 cites W2066822131 @default.
• W2955989987 cites W2067453737 @default.
• W2955989987 cites W2069923220 @default.
• W2955989987 cites W2086287098 @default.
• W2955989987 cites W2087962419 @default.
• W2955989987 cites W2091357955 @default.
• W2955989987 cites W2103117422 @default.
• W2955989987 cites W2107854895 @default.
• W2955989987 cites W2115815315 @default.
• W2955989987 cites W2121132452 @default.
• W2955989987 cites W2129980493 @default.
• W2955989987 cites W2143253342 @default.
• W2955989987 cites W2167642476 @default.
• W2955989987 cites W2190949340 @default.
• W2955989987 cites W2328305925 @default.
• W2955989987 cites W2752629114 @default.
• W2955989987 cites W2788823403 @default.
• W2955989987 cites W2794622679 @default.
• W2955989987 cites W2884694416 @default.
• W2955989987 doi "https://doi.org/10.1208/s12249-019-1436-6" @default.
• W2955989987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31172323" @default.
• W2955989987 hasPublicationYear "2019" @default.
• W2955989987 type Work @default.
• W2955989987 sameAs 2955989987 @default.
• W2955989987 citedByCount "4" @default.
• W2955989987 countsByYear W29559899872019 @default.
• W2955989987 countsByYear W29559899872020 @default.
• W2955989987 countsByYear W29559899872023 @default.
• W2955989987 crossrefType "journal-article" @default.
• W2955989987 hasAuthorship W2955989987A5016295045 @default.
• W2955989987 hasAuthorship W2955989987A5018805784 @default.
• W2955989987 hasAuthorship W2955989987A5073383878 @default.
• W2955989987 hasBestOaLocation W29559899871 @default.
• W2955989987 hasConcept C127413603 @default.
• W2955989987 hasConcept C155672457 @default.
• W2955989987 hasConcept C171250308 @default.
• W2955989987 hasConcept C178790620 @default.
• W2955989987 hasConcept C185592680 @default.
• W2955989987 hasConcept C192562407 @default.
• W2955989987 hasConcept C2777239854 @default.
• W2955989987 hasConcept C2778445172 @default.
• W2955989987 hasConcept C2778452849 @default.
• W2955989987 hasConcept C2779587474 @default.
• W2955989987 hasConcept C42360764 @default.
• W2955989987 hasConcept C43617362 @default.
• W2955989987 hasConcept C84199377 @default.
• W2955989987 hasConceptScore W2955989987C127413603 @default.
• W2955989987 hasConceptScore W2955989987C155672457 @default.
• W2955989987 hasConceptScore W2955989987C171250308 @default.
• W2955989987 hasConceptScore W2955989987C178790620 @default.
• W2955989987 hasConceptScore W2955989987C185592680 @default.
• W2955989987 hasConceptScore W2955989987C192562407 @default.
• W2955989987 hasConceptScore W2955989987C2777239854 @default.
• W2955989987 hasConceptScore W2955989987C2778445172 @default.
• W2955989987 hasConceptScore W2955989987C2778452849 @default.
• W2955989987 hasConceptScore W2955989987C2779587474 @default.
• W2955989987 hasConceptScore W2955989987C42360764 @default.
• W2955989987 hasConceptScore W2955989987C43617362 @default.
• W2955989987 hasConceptScore W2955989987C84199377 @default.
• W2955989987 hasIssue "5" @default.
• W2955989987 hasLocation W29559899871 @default.
• W2955989987 hasLocation W29559899872 @default.
• W2955989987 hasOpenAccess W2955989987 @default.
• W2955989987 hasPrimaryLocation W29559899871 @default.
• W2955989987 hasRelatedWork W2002082775 @default.
• W2955989987 hasRelatedWork W2006826318 @default.
• W2955989987 hasRelatedWork W2011111253 @default.

• next