FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955993953> ?p ?o ?g. }

• W2955993953 endingPage "184" @default.
• W2955993953 startingPage "174" @default.
• W2955993953 abstract "Summary De novo diffuse large B‐cell lymphoma (DLBCL) presenting with synchronous central nervous system (CNS) and systemic disease (synDLBCL) is not well described and is excluded from clinical trials. We performed a retrospective analysis of 80 synDLBCL patients treated across 10 Australian and UK centres. Of these patients, 96% had extranodal systemic disease. CNS‐directed treatment with combination intravenous cytarabine and high‐dose methotrexate (“CNS‐intensive”) ( n = 38) was associated with favourable survival outcomes compared with “CNS‐conservative” strategies such as intravenous high‐dose methotrexate monotherapy, intrathecal therapy and/or radiotherapy (2‐year progression‐free survival [PFS] 50% vs. 31%, P = 0·006; 2‐year overall survival [OS] 54% vs. 44%, P = 0·037). Outcomes were primarily dictated by the ability to control the CNS disease, with 2‐year cumulative CNS relapse incidence of 42% and non‐CNS relapse 21%. Two‐year OS for CNS‐relapse patients was 13% vs. 36% for non‐CNS relapses ( P = 0·02). Autologous stem cell transplantation as consolidation ( n = 14) was not observed to improve survival in those patients who received CNS‐intensive induction when matched for induction outcomes (2‐year PFS 69% vs. 56%, P = 0·99; 2‐year OS 66% vs. 56%, P = 0·98). Hyperfractionated or infusional systemic treatment did not improve survival compared to R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) (2‐year OS 49% for both groups). Our study suggests that adequate control of the CNS disease is paramount and is best achieved by intensive CNS‐directed induction." @default.
• W2955993953 created "2019-07-12" @default.
• W2955993953 creator A5006324385 @default.
• W2955993953 creator A5006503727 @default.
• W2955993953 creator A5010005600 @default.
• W2955993953 creator A5015988282 @default.
• W2955993953 creator A5021023688 @default.
• W2955993953 creator A5027391845 @default.
• W2955993953 creator A5036891893 @default.
• W2955993953 creator A5042918882 @default.
• W2955993953 creator A5044744619 @default.
• W2955993953 creator A5046515308 @default.
• W2955993953 creator A5056794809 @default.
• W2955993953 creator A5057423528 @default.
• W2955993953 creator A5069125518 @default.
• W2955993953 creator A5070144005 @default.
• W2955993953 creator A5073647747 @default.
• W2955993953 creator A5080287152 @default.
• W2955993953 creator A5081797509 @default.
• W2955993953 date "2019-06-24" @default.
• W2955993953 modified "2023-10-01" @default.
• W2955993953 title "Outcomes of synchronous systemic and central nervous system (CNS) involvement of diffuse large B‐cell lymphoma are dictated by the CNS disease: a collaborative study of the Australasian Lymphoma Alliance" @default.
• W2955993953 cites W1020989877 @default.
• W2955993953 cites W1969656117 @default.
• W2955993953 cites W2011923772 @default.
• W2955993953 cites W2063691874 @default.
• W2955993953 cites W2071364749 @default.
• W2955993953 cites W2095737226 @default.
• W2955993953 cites W2111322227 @default.
• W2955993953 cites W2111827890 @default.
• W2955993953 cites W2122729593 @default.
• W2955993953 cites W2158267770 @default.
• W2955993953 cites W2164995655 @default.
• W2955993953 cites W2171356556 @default.
• W2955993953 cites W2205958192 @default.
• W2955993953 cites W2226282127 @default.
• W2955993953 cites W2280269954 @default.
• W2955993953 cites W2314481096 @default.
• W2955993953 cites W2462981464 @default.
• W2955993953 cites W2516789978 @default.
• W2955993953 cites W2525478941 @default.
• W2955993953 cites W2531432151 @default.
• W2955993953 cites W2586303434 @default.
• W2955993953 cites W2590821302 @default.
• W2955993953 cites W2617968907 @default.
• W2955993953 cites W2762450632 @default.
• W2955993953 cites W2766491362 @default.
• W2955993953 cites W2780889590 @default.
• W2955993953 cites W2809277125 @default.
• W2955993953 cites W2919015634 @default.
• W2955993953 cites W94592798 @default.
• W2955993953 doi "https://doi.org/10.1111/bjh.16064" @default.
• W2955993953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31236941" @default.
• W2955993953 hasPublicationYear "2019" @default.
• W2955993953 type Work @default.
• W2955993953 sameAs 2955993953 @default.
• W2955993953 citedByCount "17" @default.
• W2955993953 countsByYear W29559939532020 @default.
• W2955993953 countsByYear W29559939532021 @default.
• W2955993953 countsByYear W29559939532022 @default.
• W2955993953 countsByYear W29559939532023 @default.
• W2955993953 crossrefType "journal-article" @default.
• W2955993953 hasAuthorship W2955993953A5006324385 @default.
• W2955993953 hasAuthorship W2955993953A5006503727 @default.
• W2955993953 hasAuthorship W2955993953A5010005600 @default.
• W2955993953 hasAuthorship W2955993953A5015988282 @default.
• W2955993953 hasAuthorship W2955993953A5021023688 @default.
• W2955993953 hasAuthorship W2955993953A5027391845 @default.
• W2955993953 hasAuthorship W2955993953A5036891893 @default.
• W2955993953 hasAuthorship W2955993953A5042918882 @default.
• W2955993953 hasAuthorship W2955993953A5044744619 @default.
• W2955993953 hasAuthorship W2955993953A5046515308 @default.
• W2955993953 hasAuthorship W2955993953A5056794809 @default.
• W2955993953 hasAuthorship W2955993953A5057423528 @default.
• W2955993953 hasAuthorship W2955993953A5069125518 @default.
• W2955993953 hasAuthorship W2955993953A5070144005 @default.
• W2955993953 hasAuthorship W2955993953A5073647747 @default.
• W2955993953 hasAuthorship W2955993953A5080287152 @default.
• W2955993953 hasAuthorship W2955993953A5081797509 @default.
• W2955993953 hasBestOaLocation W29559939531 @default.
• W2955993953 hasConcept C126322002 @default.
• W2955993953 hasConcept C143998085 @default.
• W2955993953 hasConcept C2776694085 @default.
• W2955993953 hasConcept C2776755627 @default.
• W2955993953 hasConcept C2778559949 @default.
• W2955993953 hasConcept C2779338263 @default.
• W2955993953 hasConcept C2779429289 @default.
• W2955993953 hasConcept C2780653079 @default.
• W2955993953 hasConcept C2781059491 @default.
• W2955993953 hasConcept C2911091166 @default.
• W2955993953 hasConcept C71924100 @default.
• W2955993953 hasConceptScore W2955993953C126322002 @default.
• W2955993953 hasConceptScore W2955993953C143998085 @default.
• W2955993953 hasConceptScore W2955993953C2776694085 @default.
• W2955993953 hasConceptScore W2955993953C2776755627 @default.
• W2955993953 hasConceptScore W2955993953C2778559949 @default.
• W2955993953 hasConceptScore W2955993953C2779338263 @default.
• W2955993953 hasConceptScore W2955993953C2779429289 @default.

• next