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- W2956004144 abstract "Significance Two of the most important issues in Parkinson’s disease (PD) research are the identification of mechanisms underlying α-synuclein cell-to-cell transfer in the nervous system and the discovery of early diagnostic biomarkers. Both of these issues are addressed in our current manuscript. Using multiple approaches, we present that α-synuclein interacts with lipoproteins within human cerebrospinal fluid and can be taken up by cells in such a state. Moreover, using cerebrospinal fluid samples from 3 large and independent cohorts of patients, we demonstrate that apolipoprotein E is elevated in early, not yet medicated, patients with PD. Finally, using postmortem brain tissue, we provide preliminary histological evidence that apolipoprotein E is enriched in a subpopulation of dopaminergic neurons of human substantia nigra." @default.
- W2956004144 created "2019-07-12" @default.
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- W2956004144 date "2019-07-03" @default.
- W2956004144 modified "2023-10-18" @default.
- W2956004144 title "α-synuclein−lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients" @default.
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- W2956004144 doi "https://doi.org/10.1073/pnas.1821409116" @default.
- W2956004144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6660770" @default.
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