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• W2956004800 endingPage "2028" @default.
• W2956004800 startingPage "2023" @default.
• W2956004800 abstract "Abstract Background Noroviruses are the major cause of viral gastroenteritis. Disease transmission is difficult to prevent and outbreaks in health-care facilities commonly occur. Contact with infected persons and contaminated environments are believed to be the main routes of transmission. However, noroviruses have recently been found in aerosols and airborne transmission has been suggested. The aim of our study was to investigate associations between symptoms of gastroenteritis and the presence of airborne norovirus, and to investigate the size of norovirus-carrying particles. Methods Air sampling was repeatedly performed close to 26 patients with norovirus infections. Samples were analyzed for norovirus RNA by reverse transcription quantitative polymerase chain reaction. The times since each patient’s last episodes of vomiting and diarrhea were recorded. Size-separating aerosol particle collection was performed. Results Norovirus RNA was found in 21 (24%) of 86 air samples from 10 different patients. Only air samples during outbreaks, or before a succeeding outbreak, tested positive for norovirus RNA. Airborne norovirus RNA was also strongly associated with a shorter time period since the last vomiting episode (odds ratio 8.1; P = .04 within 3 hours since the last vomiting episode). The concentrations of airborne norovirus ranged from 5–215 copies/m3, and detectable amounts of norovirus RNA were found in particles &lt;0.95 µm and &gt;4.51 µm. Conclusions The results suggest that recent vomiting is the major source of airborne norovirus and imply a connection between airborne norovirus and outbreaks. The presence of norovirus RNA in submicrometre particles indicates that airborne transmission can be an important transmission route." @default.
• W2956004800 created "2019-07-12" @default.
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• W2956004800 date "2019-07-29" @default.
• W2956004800 modified "2023-10-17" @default.
• W2956004800 title "Sources of Airborne Norovirus in Hospital Outbreaks" @default.
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• W2956004800 doi "https://doi.org/10.1093/cid/ciz584" @default.
• W2956004800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7201413" @default.
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