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- W2956005870 abstract "AIM: To investigate the frequencies and association of polymorphic genotypes of IL-8 -251 T>A, TNF-α -308G>A, ICAM-1 K469E, ICAM-1 R241G, IL-6 -174 G>C, and PPAR-γ 34 C>G in modulating susceptibility risk inMalaysian colorectal cancer (CRC) patients. Methods: In this case-control study, peripheral blood samples of 560study subjects (280 CRC patients and 280 controls) were collected, DNA extracted and genotyped using PCR-RFLPand Allele Specific PCR. The association between polymorphic genotype and CRC susceptibility risk was determinedusing Logistic Regression analysis deriving Odds ratio (OR) and 95% CI. Results: On comparing the frequencies ofgenotypes of all single nucleotide polymorphisms ( SNPs ) in patients and controls, the homozygous variant genotypesIL-8 -251 AA and TNF-α -308 AA and variant A alleles were significantly higher in CRC patients. Investigation onthe association of the variant alleles and genotypes singly, with susceptibility risk showed the homozygous variant Aalleles and genotypes IL-8 -251 AA and TNF-α -308 AA to be at higher risk for CRC predisposition. Analysis basedon age, gender and smoking habits showed that the polymorphisms IL8 -251 T>A and TNF – α 308 G>A contributeto a significantly higher risk among male and female who are more than 50 years and for smokers in this population.Conclusion: We observed an association between variant allele and genotypes of IL-8-251 T>A and TNF-α-308G>A polymorphisms and CRC susceptibility risk in Malaysian patients. These two SNPs in inflammatory responsegenes which undoubtedly contribute to individual risks to CRC susceptibility may be considered as potential geneticpredisposition factors for CRC in Malaysian population." @default.
- W2956005870 created "2019-07-12" @default.
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- W2956005870 date "2019-06-01" @default.
- W2956005870 modified "2023-09-23" @default.
- W2956005870 title "Contribution of Genetic Polymorphisms of Inflammation Response Genes on Sporadic Colorectal Cancer Predisposition Risk in Malaysian Patients – A Case Control Study" @default.
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- W2956005870 doi "https://doi.org/10.31557/apjcp.2019.20.6.1621" @default.
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