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- W2956006975 abstract "The ability ofMycobacterium tuberculosis to persist in a dormant state is a hallmarkof tuberculosis. An insight into the expression of mycobacterial proteins willcontribute to our understanding of bacterial physiology in vivo. To this end, theexpression of FtsZ, Acr and DevR was assessed in the lung granulomas of guineapigs infected with M. tuberculosis. Antigen immunostaining was then comparedwith the detection of acid-fast bacilli (AFB) and mycobacterial DNA. Surprisingly,immunostaining for all three antigens was observed throughout the course ofinfection; maximum expression of all antigens was noted at 20 weeks of infection.The intensity of immunostaining correlated well with the presence of intactbacteria, suggesting that mycobacterial antigens in the extracellular fraction havea short half-life; in contrast to protein, extracellular bacterial DNAwas found to bemore stable. Immunostaining for bacterial division and dormancy markerscould not clearly distinguish between replicating and non-replicating organismsduring the course of infection. The detection of Acr and DevR from 4 weeksonwards indicates that the dormancy proteins are expressed from early on ininfection. Both antigen staining and DNA detection from intact bacilli were usefulfor detecting intact mycobacteria in the absence of AFB." @default.
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- W2956006975 date "2006-01-01" @default.
- W2956006975 modified "2023-09-27" @default.
- W2956006975 title "Expression ofmycobacterial cell division protein, FtsZ, anddormancy proteins,DevR andAcr,within lung granulomasthroughout guinea pig infection" @default.
- W2956006975 hasPublicationYear "2006" @default.
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