Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956007068> ?p ?o ?g. }
- W2956007068 endingPage "4039" @default.
- W2956007068 startingPage "4031" @default.
- W2956007068 abstract "Chitosan is a polysaccharide capable of augmenting immune responses with a proven safety record in animals and humans. These properties make it a potentially attractive agent for the prevention and treatment of infectious disease. Infection by respiratory syncytial virus (RSV) is the leading cause of serious lower respiratory disease in young children throughout the world. There is no licensed vaccine available against RSV whereas inactivated vaccine is known to cause enhanced respiratory disease instead of protection. Here, we investigated whether chitosan administered one or three days post-infection could protect animals against RSV infection and whether it could alter immune responses or immunopathology induced by inactivated RSV vaccine when administered twice before RSV infection. We found chitosan could modestly protect animals against RSV infection when given post-infection, while, in conjunction with inactivated RSV vaccine when given pre-infection, it could significantly reduce RSV infection in mice. Further mechanistic investigation revealed that chitosan enhanced antigen-specific immune responses through augmenting the induction of regulatory T cells, lung resident T cells and neutralizing antibodies while reversing Th2-skewed immune responses induced by inactivated RSV vaccine but, surprisingly, failing to reverse lung histopathology. Overall, this study sheds more light on the molecular mechanisms underlying inactivated RSV vaccine-induced disease." @default.
- W2956007068 created "2019-07-12" @default.
- W2956007068 creator A5005863979 @default.
- W2956007068 creator A5009405621 @default.
- W2956007068 creator A5019410689 @default.
- W2956007068 creator A5021386028 @default.
- W2956007068 creator A5031875473 @default.
- W2956007068 creator A5043859457 @default.
- W2956007068 creator A5056204035 @default.
- W2956007068 creator A5060597852 @default.
- W2956007068 creator A5063839540 @default.
- W2956007068 creator A5069896119 @default.
- W2956007068 creator A5087586096 @default.
- W2956007068 creator A5090162954 @default.
- W2956007068 date "2019-07-01" @default.
- W2956007068 modified "2023-10-11" @default.
- W2956007068 title "Chitosan alters inactivated respiratory syncytial virus vaccine elicited immune responses without affecting lung histopathology in mice" @default.
- W2956007068 cites W1502260800 @default.
- W2956007068 cites W1579211517 @default.
- W2956007068 cites W1593106624 @default.
- W2956007068 cites W1730034722 @default.
- W2956007068 cites W1894593978 @default.
- W2956007068 cites W1913350003 @default.
- W2956007068 cites W1925238017 @default.
- W2956007068 cites W1963943570 @default.
- W2956007068 cites W1968780381 @default.
- W2956007068 cites W1972191954 @default.
- W2956007068 cites W1972662046 @default.
- W2956007068 cites W1987844503 @default.
- W2956007068 cites W1988474688 @default.
- W2956007068 cites W1999845199 @default.
- W2956007068 cites W2010378312 @default.
- W2956007068 cites W2013168158 @default.
- W2956007068 cites W2022785778 @default.
- W2956007068 cites W2023089158 @default.
- W2956007068 cites W2025733005 @default.
- W2956007068 cites W2030378290 @default.
- W2956007068 cites W2031454484 @default.
- W2956007068 cites W2034253067 @default.
- W2956007068 cites W2036117709 @default.
- W2956007068 cites W2037123168 @default.
- W2956007068 cites W2039102288 @default.
- W2956007068 cites W2046700010 @default.
- W2956007068 cites W2056315834 @default.
- W2956007068 cites W2068194705 @default.
- W2956007068 cites W2073208965 @default.
- W2956007068 cites W2101114010 @default.
- W2956007068 cites W2102018690 @default.
- W2956007068 cites W2112303521 @default.
- W2956007068 cites W2113628320 @default.
- W2956007068 cites W2116486619 @default.
- W2956007068 cites W2116973575 @default.
- W2956007068 cites W2118919020 @default.
- W2956007068 cites W2120949068 @default.
- W2956007068 cites W2123397921 @default.
- W2956007068 cites W2123817481 @default.
- W2956007068 cites W2125685304 @default.
- W2956007068 cites W2134243066 @default.
- W2956007068 cites W2134249387 @default.
- W2956007068 cites W2135579715 @default.
- W2956007068 cites W2140368190 @default.
- W2956007068 cites W2144021590 @default.
- W2956007068 cites W2148326845 @default.
- W2956007068 cites W2151322257 @default.
- W2956007068 cites W2154567574 @default.
- W2956007068 cites W2154899729 @default.
- W2956007068 cites W2157954415 @default.
- W2956007068 cites W2396231518 @default.
- W2956007068 cites W2468035250 @default.
- W2956007068 cites W2556185967 @default.
- W2956007068 cites W2752879464 @default.
- W2956007068 cites W2782068718 @default.
- W2956007068 doi "https://doi.org/10.1016/j.vaccine.2019.06.003" @default.
- W2956007068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31186190" @default.
- W2956007068 hasPublicationYear "2019" @default.
- W2956007068 type Work @default.
- W2956007068 sameAs 2956007068 @default.
- W2956007068 citedByCount "20" @default.
- W2956007068 countsByYear W29560070682019 @default.
- W2956007068 countsByYear W29560070682020 @default.
- W2956007068 countsByYear W29560070682021 @default.
- W2956007068 countsByYear W29560070682022 @default.
- W2956007068 countsByYear W29560070682023 @default.
- W2956007068 crossrefType "journal-article" @default.
- W2956007068 hasAuthorship W2956007068A5005863979 @default.
- W2956007068 hasAuthorship W2956007068A5009405621 @default.
- W2956007068 hasAuthorship W2956007068A5019410689 @default.
- W2956007068 hasAuthorship W2956007068A5021386028 @default.
- W2956007068 hasAuthorship W2956007068A5031875473 @default.
- W2956007068 hasAuthorship W2956007068A5043859457 @default.
- W2956007068 hasAuthorship W2956007068A5056204035 @default.
- W2956007068 hasAuthorship W2956007068A5060597852 @default.
- W2956007068 hasAuthorship W2956007068A5063839540 @default.
- W2956007068 hasAuthorship W2956007068A5069896119 @default.
- W2956007068 hasAuthorship W2956007068A5087586096 @default.
- W2956007068 hasAuthorship W2956007068A5090162954 @default.
- W2956007068 hasConcept C105702510 @default.
- W2956007068 hasConcept C126322002 @default.