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- W2956034641 endingPage "907" @default.
- W2956034641 startingPage "907" @default.
- W2956034641 abstract "Epithelial ovarian cancer is a highly lethal gynecological malignancy that is characterized by the early development of disseminated metastasis. Though ovarian cancer has been generally considered to preferentially metastasize via direct transcoelomic dissemination instead of the hematogenous route, emerging evidence has indicated that the hematogenous spread of cancer cells plays a larger role in ovarian cancer metastasis than previously thought. Considering the distinctive biology of ovarian cancer, an in-depth understanding of the biological and molecular mechanisms that drive metastasis is critical for developing effective therapeutic strategies against this fatal disease. The recent “cancer stem cell theory” postulates that cancer stem cells are principally responsible for tumor initiation, metastasis, and chemotherapy resistance. Even though the hallmarks of ovarian cancer stem cells have not yet been completely elucidated, metastasized ovarian cancer cells, which have a high degree of chemoresistance, seem to manifest cancer stem cell properties and play a key role during relapse at metastatic sites. Herein, we review our current understanding of the cell-biological mechanisms that regulate ovarian cancer metastasis and chemotherapy resistance, with a pivotal focus on ovarian cancer stem cells, and discuss the potential clinical implications of evolving cancer stem cell research and resultant novel therapeutic approaches." @default.
- W2956034641 created "2019-07-12" @default.
- W2956034641 creator A5026982152 @default.
- W2956034641 creator A5090361588 @default.
- W2956034641 date "2019-06-28" @default.
- W2956034641 modified "2023-10-09" @default.
- W2956034641 title "Ovarian Cancer Stemness: Biological and Clinical Implications for Metastasis and Chemotherapy Resistance" @default.
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