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- W2956037799 abstract "Aim: Blood perfusion-based requirement of nanoparticle dose-loadings is computed for plasmonic photothermal therapy of a tumor. Methods: Thermal damage is quantified through coupled multiphysics approach to specify nanoparticle loadings. Results: For low blood perfusion, the nanoparticle loading of 1 mm at 0.02 mg/ml or 3 mm at 0.2 mg/ml concentration may be chosen depending upon the desired tumor margins. For high blood perfusion, nanoparticle loading of 3 mm at 0.2 mg/ml concentration with irradiation parameters of 1 W/cm 2 and 200 s seems desirable. Conclusion: Lower nanoparticle loadings within deeper periphery of tumor damage the deeper healthy tissue. If tumor margin is not to be ablated, then higher nanoparticle loadings should be opted instead of higher irradiation duration." @default.
- W2956037799 created "2019-07-12" @default.
- W2956037799 creator A5032688944 @default.
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- W2956037799 date "2019-07-01" @default.
- W2956037799 modified "2023-09-23" @default.
- W2956037799 title "Tumor blood perfusion-based requirement of nanoparticle dose-loadings for plasmonic photothermal therapy" @default.
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- W2956037799 doi "https://doi.org/10.2217/nnm-2018-0494" @default.
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