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- W2956042783 abstract "BACKGROUND: Despite therapeutic hypothermia (TH), half of all neonates with hypoxic-ischemic encephalopathy (HIE) still die or suffer severe neurologic sequelae. The secondary energy failure (SEF) is the most vulnerable period for brain injury and its severity correlates with degree of impairment. The SEF begins 8-16 hr post insult and peaks at 24-48 hr. A quantitative, early method of measuring brain viability and injury severity is needed to guide application of adjuvant neuroprotective agents. Magnetic resonance H1-spectroscopy (MRS) measures concentrations of cerebral metabolites to elucidate derangements in aerobic metabolism. MR diffusion weighted …" @default.
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- W2956042783 date "2018-05-01" @default.
- W2956042783 modified "2023-09-26" @default.
- W2956042783 title "Very Early MRI During Therapeutic Hypothermia to Measure Severity of Brain Injury in Neonates with Hypoxic-Ischemic Encephalopathy" @default.
- W2956042783 doi "https://doi.org/10.1542/peds.142.1_meetingabstract.190" @default.
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