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- W2956058406 abstract "Background/Aim: Chloride intracellular channel 1 (CLIC1) represents a promising target for personalized therapy. Our aim was to assess CLIC1 expression in clear cell renal cell carcinoma (cc RCC) and identify its possible prognostic role. Materials and Methods: Fifty cases of cc RCC were evaluated and selected for immunohistochemistry. CLIC1 expression was correlated with tumor grade, invasion and heterogeneity. Results: A total of 87.5% of the cases were CLIC1 positive, with either a homogeneous (31.42%) or a heterogeneous (68.57%) pattern. Low, mild and strong CLIC1 expressing tumors were defined based on nuclear (N), cytoplasmic (C), membrane (M) or combinations of them (NC, NM, CM, NCM) in terms of CLIC1 distribution. A significant correlation was found between tumor grade and percent of positive tumor cells (p=0.017). For G3 tumors, CLIC1 cytoplasmic expression was strongly correlated with high expression status (p=0.025) and tumor heterogeneity (p=0.004). CLIC1 expression was also correlated with metastasis (p=0.046). Conclusion: We defined four cc RCC groups depending on G, CLIC1 expression and pattern: i) G3/NM/low CLIC1<sup>+</sup>, ii) G2/CM/mild CLIC1<sup>+</sup> iii) G1 or G2/NM or CM /high CLIC1<sup>+</sup>, and iv) G2/M /high CLIC1<sup>+</sup>." @default.
- W2956058406 created "2019-07-12" @default.
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- W2956058406 date "2019-01-01" @default.
- W2956058406 modified "2023-10-18" @default.
- W2956058406 title "Intracellular Chloride Ion Channel Protein-1 Expression in Clear Cell Renal Cell Carcinoma" @default.
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- W2956058406 doi "https://doi.org/10.21873/cgp.20135" @default.
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