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• W2956079501 abstract "ABSTRACT There is circumstantial evidence that, under neurodegenerative conditions, peptides deriving from aggregated or misfolded specific proteins elicit adaptive immune responses. On another hand, several genes involved in familial forms of neurodegenerative diseases were found to exert key innate immune functions. However, whether or not such observations are causally linked remains unknown. To start addressing this issue, we followed a systems biology strategy based on the mining of large proteomics and immunopeptidomics databases. First, we retrieved the expression patterns of common neurodegeneration-associated proteins in two professional antigen-presenting cells, namely B-cells and dendritic cells. Surprisingly, we found that under physiological conditions, numerous neurodegeneration-associated proteins are abundantly expressed by human B-cells. A survey of the human proteome allowed us to map a unique protein-protein interaction network linking common neurodegeneration-associated proteins and their first shell interactors in human B-cells. Surprisingly, network connectivity analysis identified two major hubs that both relate with inflammation and autophagy, namely TRAF6 (TNF Receptor Associated Factor 6) and SQSTM1 (Sequestosome-1). Moreover, the mapped network in B-cells also comprised two other hub proteins involved in both inflammation and autoimmunity: HSPA8 (Heat Shock Protein Family A Member 8 also known as HSC70) and HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1). Based on these results, we then explored the Immune Epitope Database “IEDB-AR” and actually found that a large share of neurodegeneration-associated proteins were previously reported to provide endogenous MHC class II-binding peptides in human B-cells. Of note, peptides deriving from amyloid beta A4 protein, sequestosome-1 or profilin-1 were reported to bind multiple allele-specific MHC class II molecules. In contrast, peptides deriving from microtubule-associated protein tau, presenilin 2 and serine/threonine-protein kinase TBK1 were exclusively reported to bind MHC molecules encoded by the HLA-DRB1 1501 allele, a recently-identified susceptibility gene for late onset Alzheimer’s disease. Finally, we observed that the whole list of proteins reported to provide endogenous MHC class II-binding peptides in human B-cells is specifically enriched in neurodegeneration-associated proteins. Overall, our work indicates that immunization against neurodegeneration-associated proteins might be a physiological process which is shaped, at least in part, by B-cells." @default.
• W2956079501 created "2019-07-12" @default.
• W2956079501 creator A5015318372 @default.
• W2956079501 creator A5052459324 @default.
• W2956079501 creator A5065112879 @default.
• W2956079501 date "2019-07-02" @default.
• W2956079501 modified "2023-09-26" @default.
• W2956079501 title "Common neurodegeneration-associated proteins are physiologically expressed by antigen-presenting cells and are interconnected via the inflammation/autophagy-related proteins TRAF6 and SQSTM1" @default.
• W2956079501 cites W1483463686 @default.
• W2956079501 cites W1532719760 @default.
• W2956079501 cites W1563280732 @default.
• W2956079501 cites W1967640115 @default.
• W2956079501 cites W1969095017 @default.
• W2956079501 cites W1971196542 @default.
• W2956079501 cites W197448336 @default.
• W2956079501 cites W1979635373 @default.
• W2956079501 cites W1983509809 @default.
• W2956079501 cites W1983981307 @default.
• W2956079501 cites W1991189569 @default.
• W2956079501 cites W2003995652 @default.
• W2956079501 cites W2008201895 @default.
• W2956079501 cites W2013932229 @default.
• W2956079501 cites W2014182955 @default.
• W2956079501 cites W2016906755 @default.
• W2956079501 cites W2033158384 @default.
• W2956079501 cites W2034265860 @default.
• W2956079501 cites W2034306306 @default.
• W2956079501 cites W2046428284 @default.
• W2956079501 cites W2051731494 @default.
• W2956079501 cites W2052042076 @default.
• W2956079501 cites W2053039860 @default.
• W2956079501 cites W2053147009 @default.
• W2956079501 cites W2053153859 @default.
• W2956079501 cites W2055039738 @default.
• W2956079501 cites W2056499061 @default.
• W2956079501 cites W2059385530 @default.
• W2956079501 cites W2061414876 @default.
• W2956079501 cites W2064222320 @default.
• W2956079501 cites W2068747215 @default.
• W2956079501 cites W2090495266 @default.
• W2956079501 cites W2090924311 @default.
• W2956079501 cites W2094393226 @default.
• W2956079501 cites W2101280135 @default.
• W2956079501 cites W2110729320 @default.
• W2956079501 cites W2111917577 @default.
• W2956079501 cites W2127148071 @default.
• W2956079501 cites W2127968624 @default.
• W2956079501 cites W2140403277 @default.
• W2956079501 cites W2142820307 @default.
• W2956079501 cites W2146010687 @default.
• W2956079501 cites W2146546145 @default.
• W2956079501 cites W2149054236 @default.
• W2956079501 cites W2159675211 @default.
• W2956079501 cites W2161354474 @default.
• W2956079501 cites W2170151170 @default.
• W2956079501 cites W2170240282 @default.
• W2956079501 cites W2200279205 @default.
• W2956079501 cites W2257167523 @default.
• W2956079501 cites W2264133902 @default.
• W2956079501 cites W2275879522 @default.
• W2956079501 cites W2304886140 @default.
• W2956079501 cites W2336583997 @default.
• W2956079501 cites W2345356016 @default.
• W2956079501 cites W2418163790 @default.
• W2956079501 cites W2421005865 @default.
• W2956079501 cites W2469928790 @default.
• W2956079501 cites W2473481432 @default.
• W2956079501 cites W2507170775 @default.
• W2956079501 cites W2519093943 @default.
• W2956079501 cites W2519934367 @default.
• W2956079501 cites W2542427033 @default.
• W2956079501 cites W2548767848 @default.
• W2956079501 cites W2590694857 @default.
• W2956079501 cites W2592954747 @default.
• W2956079501 cites W2605285953 @default.
• W2956079501 cites W2611932423 @default.
• W2956079501 cites W2620784329 @default.
• W2956079501 cites W2622719965 @default.
• W2956079501 cites W2638382976 @default.
• W2956079501 cites W2726442376 @default.
• W2956079501 cites W2736657964 @default.
• W2956079501 cites W2743677958 @default.
• W2956079501 cites W2767122588 @default.
• W2956079501 cites W2768988215 @default.
• W2956079501 cites W2770235504 @default.
• W2956079501 cites W2771317902 @default.
• W2956079501 cites W2783108014 @default.
• W2956079501 cites W2785372204 @default.
• W2956079501 cites W2789764978 @default.
• W2956079501 cites W2790187919 @default.
• W2956079501 cites W2792159300 @default.
• W2956079501 cites W2792496692 @default.
• W2956079501 cites W2792618073 @default.
• W2956079501 cites W2793084066 @default.
• W2956079501 cites W2793838555 @default.
• W2956079501 cites W2803787904 @default.
• W2956079501 cites W2810945462 @default.
• W2956079501 cites W2811446190 @default.
• W2956079501 cites W2887997888 @default.
• W2956079501 cites W2889142244 @default.

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