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- W2956087185 abstract "Abstract Schizophrenia is a complex and severe psychiatric disorder with a variety of symptoms including positive symptoms (delusions and hallucinations), thought disorder, negative symptoms, and cognitive changes. The classic etiologic hypothesis for schizophrenia is based on changes in dopaminergic activity in the CNS. Medications used to alleviate psychotic symptoms rely mostly on antagonism of dopamine receptors, in particular the D2 subclass. Etiologic studies of schizophrenia point to a complex interplay between genetic and environmental factors. Schizophrenia is associated with disturbances in wake-sleep control and sleep architecture, with those changes being more closely tied to positive symptoms. Altered gamma band activity and coherence along with increased expression of neuronal calcium sensor protein 1 are also seen in schizophrenia. Findings from EEG, reflex, and P50 potential studies point to increased arousal and rapid eye movement sleep drive in schizophrenia. While current treatment options rely on the traditional dopamine hypothesis, future alternatives are likely to emerge from the understanding of the basic physiological mechanisms underlying this complex brain disorder." @default.
- W2956087185 created "2019-07-12" @default.
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- W2956087185 date "2019-01-01" @default.
- W2956087185 modified "2023-10-14" @default.
- W2956087185 title "Schizophrenia and arousal" @default.
- W2956087185 doi "https://doi.org/10.1016/b978-0-12-817992-5.00003-9" @default.
- W2956087185 hasPublicationYear "2019" @default.
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