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- W2956100979 abstract "Metabolic Syndrome (MetS) increases the risk of cardiovascular and all-cause mortality. High blood pressure is the most frequent factor of MetS. General guidelines for hypertension recommend both pharmacological and exercise treatment while their combined effects on blood pressure have not been thoroughly explored yet. PURPOSE: To compare the blood pressure (BP) response to a bout of supramaximal aerobic interval exercise (SIE) alone or in combination with antihypertensive medication in MetS hypertensive patients. METHODS: Twelve patients chronically medicated with angiotensin II receptor 1 blockade antihypertensive medicine (AHM), underwent 3 trials separated by 1 week in a randomized order: a) control trial without exercise and substituting their AHM by a placebo (PLAC); b) placebo medicine and a morning bout of SIE (PLAC+SIE) and c) combining AHM and exercise (AHM+SIE). Acute and ambulatory blood pressure responses were measured for 21-h after treatments. Repeated-measures crossover, double-blind, placebo randomized design was used. RESULTS: Acutely (i.e., 20 min after treatments), systolic blood pressure (SBP) were reduced similarly after PLAC+SIE (- 9.7 ± 6.0 mmHg, P<0.001) and AHM+SIE (-10.4 ± 7.9 mmHg, P=0.001). Chronically, (21-h following treatments) SBP remained reduced after PLAC+SIE (125 ± 12mmHg, P=0.022) and AHM+SIE (122 ± 12 mmHg, P=0.013) in comparison to PLAC (132 ± 16 mmHg). The BP reduction in PLAC+SIE faded out at 4 a.m., whilst in AHM+SIE continued over the complete measurement period (Figure 1). At nighttime BP reduction was larger in AHM+SIE than PLAC+SIE (-5.6 ± 4.0 mmHg, P=0.006). CONCLUSION: Our data show that a bout of supramaximal aerobic interval exercise in combination with antihypertensive medication in the morning elicits a sustained blood pressure reduction that lasts at least 21-h. Exercise potentiates the effects of antihypertensive medicine reducing blood pressure longer and at a larger magnitude than exercise alone." @default.
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- W2956100979 date "2019-06-01" @default.
- W2956100979 modified "2023-10-18" @default.
- W2956100979 title "Ambulatory Blood Pressure Reduction In Response To Supramaximal Interval Exercise; Interactions With Antihypertensive Medication." @default.
- W2956100979 doi "https://doi.org/10.1249/01.mss.0000561027.79903.33" @default.
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