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- W2956103501 abstract "Bathing an enzyme in blue-green light has enabled researchers to completely change its catalytic function so that it carries out a ring-forming reaction not found in nature. The team, led by Todd K. Hyster at Princeton University, used this strategy to build a range of cyclic lactams, a motif found in pharmaceuticals and agrochemicals (Science 2019, DOI: 10.1126/science.aaw1143). The chemists worked with a family of enzymes called ene-reductases, which are thought to help certain microbes combat oxidative stress. The enzymes’ large active sites harbor a flavin cofactor that plays an essential role in their natural reaction, transferring a hydride anion and a proton to double bonds to reduce troublesome metabolites. But Hyster’s team found that shining cyan light onto the flavin puts it into an excited state that makes it a potent single-electron reductant. This enables a radical reaction that can transform a variety of α-chloroamides into lactam rings containing" @default.
- W2956103501 created "2019-07-12" @default.
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- W2956103501 date "2019-06-24" @default.
- W2956103501 modified "2023-10-16" @default.
- W2956103501 title "Light gives enzyme a radical new role" @default.
- W2956103501 doi "https://doi.org/10.1021/cen-09725-scicon3" @default.
- W2956103501 hasPublicationYear "2019" @default.
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